Can inflammation worsen the prognosis of severe subarachnoid hemorrhage

• Project/Area Number: 15K10284
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Hokkaido University
• Principal Investigator: HOKARI Masaaki 北海道大学, 医学研究院, 客員研究員 (30622807)
• Co-Investigator(Kenkyū-buntansha): 七戸 秀夫 北海道大学, 大学病院, 准教授 (80374479) ; 中山 若樹 北海道大学, 医学研究院, 講師 (40421961) ; 寳金 清博 北海道大学, 大学病院, 教授 (90229146)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ミノサイクリン / くも膜下出血 / 炎症 / 低体温 / 動物モデル / 核医学的検討 / 脳保護薬 / 細胞治療 / 脳低温療法

Outline of Final Research Achievements

Inflammation process following severe subarachnoid hemorrhage may exacerbate neuronal damage. Recent studies have revealed that microglia may play an important role in brain inflammation after cerebral damage, however the role of microglia after subarachnoid hemorrhage is not well understood. The authors have conducted a basic research to figure out whether hypothermia and minocycline which is the suppresive drug of microglia will work against inflammation after subarachnoid hemorrhage.

Research Products

• [Journal Article] Effect of Headache on the Pathologic Findings of Unruptured Cerebral Saccular Aneurysms (2017)
  • Author(s): Hokari Masaaki、Nakayama Naoki、Shimoda Yusuke、Houkin Kiyohiro
  • Journal Title: World Neurosurg Volume: 103 Pages: 431-441
  • DOI: 10.1016/j.wneu.2017.01.069
  • Peer Reviewed
• [Journal Article] Surgical Outcome of Cerebral Aneurysm Clipping Treated with Immunosuppressants: Report of 11 Cases and Review of the Literature (2017)
  • Author(s): Hokari M, Nakayama N, Kazumata K, Osanai T, Shichinohe H, Abumiya T, Houkin K.
  • Journal Title: Neurologia medico-chirurgica Volume: 57 Issue: 3 Pages: 122-127
  • DOI: 10.2176/nmc.oa.2016-0185
  • NAID: 130005439797
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Feasibility and Efficiency of Human Bone Marrow Stromal Cell Culture with Allogeneic Platelet Lysate- Supplementation for Cell Therapy against Stroke. (2016)
  • Author(s): Tan C, Shichinohe H, Wang Z, Hamauchi S, Abumiya T, Nakayama N, Kazumata K, Ito T, Kudo K, Takamoto S, Houkin K.
  • Journal Title: Stem Cells Int. Volume: 2016 Pages: 107780-107780
  • Peer Reviewed / Open Access
• [Journal Article] Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion. (2016)
  • Author(s): Kurisu K, Abumiya T, Ito M, Gekka M, Osanai T, Shichinohe H, Nakayama N, Kazumata K, Houkin K.
  • Journal Title: Brain Res. Volume: 1651 Pages: 95-103
  • DOI: 10.1016/j.brainres.2016.09.017
  • NAID: 120006360058
  • Peer Reviewed
• [Journal Article] Cellular Functions and Gene and Protein Expression Profiles in Endothelial Cells Derived from Moyamoya Disease-Specific iPS Cells. (2016)
  • Author(s): Hamauchi S, Shichinohe H, Uchino H, Yamaguchi S, Nakayama N, Kazumata K, Osanai T, Abumiya T, Houkin K, Era T.
  • Journal Title: PLoS One. Volume: 11(9) Issue: 9 Pages: e0163561-e0163561
  • DOI: 10.1371/journal.pone.0163561
  • Peer Reviewed / Open Access
• [Journal Article] Transarterial Regional Brain Hypothermia Inhibits Acute Aquaporin-4 Surge and Sequential Microvascular Events in Ischemia/Reperfusion Injury. (2015)
  • Author(s): Kurisu K, Abumiya T, Nakamura H, Shimbo D, Shichinohe H, Nakayama N, Kazumata K, Shimizu H, Houkin K.
  • Journal Title: Neurosurgery Volume: Epub ahead of print Issue: 1 Pages: 125-134
  • DOI: 10.1227/neu.0000000000001088
  • Peer Reviewed
• [Journal Article] Surgical Outcomes for Cervical Carotid Artery Stenosis: Treatment Strategy for Bilateral Cervical Carotid Artery Stenosis. (2015)
  • Author(s): Hokari M, Nakayama N, Kazumata K, Osanai T, Nakamura T, Yasuda H, Ushikoshi S, Shichinohe H, Abumiya T, Kuroda S, Houkin K.
  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 24 Issue: 8 Pages: 1768-74
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.03.052
  • Peer Reviewed
• [Journal Article] Pathological findings of saccular cerebral aneurysms-impact of subintimal fibrin deposition on aneurysm rupture. (2015)
  • Author(s): Hokari M, Nakayama N, Nishihara H, Houkin K.
  • Journal Title: Neurosurg Rev. Volume: 38 Issue: 3 Pages: 113-8
  • DOI: 10.1007/s10143-015-0628-0
  • NAID: 120005768780
  • Peer Reviewed
• [Journal Article] Neuroprotective effects of cilostazol are mediated by multiple mechanisms in a mouse model of permanent focal ischemia. (2015)
  • Author(s): Shichinohe H, Tan C, Abumiya T, Nakayama N, Kazumata K, Hokari M, Houkin K, Kuroda S.
  • Journal Title: Brain Research Volume: 1602 Pages: 53-61
  • DOI: 10.1016/j.brainres.2015.01.022
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Investigation of Inflammatory changes in brain and lymphoid organs after brain stroke for the CNS regeneration therapy with bone marrow stromal cell transplantation (2017)
  • Author(s): Chengbo Tan, Zifeng Wang, Hideo Shichinohe, Masahito Kawabori, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Masaaki Hokari and Kiyohiro Houkin
  • Organizer: International Stroke Conference 2017
  • Place of Presentation: テキサス州ヒューストン、米国
  • Year and Date: 2017-02-22
  • Int'l Joint Research
• [Book] Cell Therapy Against Stroke (2017)
  • Author(s): Kiyohiro Houkin, Koji Abe, Satoshi Kuroda
  • Total Pages: 156
  • Publisher: Springer