| Project/Area Number |
15K10295
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
見崎 孝一 金沢大学, 大学病院, 助教 (20507082)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | aneurysm / embolization / neck orifice / porous scaffold / 脳動脈瘤 / 新生内膜 / 多孔質足場 / セルロースポーラスビーズ / 塞栓物質 / cellulose porrous beads / cellulose porous bead |
|---|
| Outline of Final Research Achievements |
Regeneration of the vessel wall structure at the aneurysmal neck orifice is important but does not readily occur with coil embolization, which is commonly used to treat cerebral aneurysms. To promote vessel wall regeneration, a scaffold of cellulose porous bead (CPB) was used as a material for aneurysm embolization. A rat external carotid artery (ECA) aneurysm model was created, and a single CPB with a diameter similar to the diameter of the ECA was placed in the aneurysm. The layer of regenerating αSMA-positive spindle cells at the aneurysm neck orifice was recognized as early as 2 weeks after implantation of the CPB, and maintained its thickness by 6 months. A monolayer of factor VIII-positive cells appeared at the neck at 2 weeks, and covered the entire neck by 6 months. CPBs might be appropriate as an embolization material for inducing vessel wall regeneration at the neck of an aneurysm.
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