Relashionship between cognitive function and amino acid dynamics in the brain using positron emission tomography in patients udergoing carotid endarterectomy

• Project/Area Number: 15K10313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Iwate Medical University
• Principal Investigator: Kunaiki Ogasawara 岩手医科大学, 医学部, 教授 (00305989)
• Research Collaborator: YOSHIDA Kenji ; KOBAYASHI Masakazu ; FUJIWARA Shunrou
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 頚動脈内膜剥離術 / 認知機能 / 神経受容体 / アミノ酸代謝 / 頚部頚動脈内膜剥離術 / 大脳皮質神経受容体 / 脳アミノ酸代謝

Outline of Final Research Achievements

Uptakes of three radiotracers for amino acid on positron emission tomography were significantly more greatly increased in patients with postoperative cognitive improvement than in those without. In particular, uptake changes of 18F-Fluoro-α-methyl-L-Tyrosine mostly correlated with degree of postoperative cognitive improvement. These findings suggested that an increase in functional activity of neuroreceptor is associated with cognitive improvement after carotid ebdarterectomy and that an increase in amino acid metabolism is associated with an increase in functional activity of neuroreceptor.

Research Products

• [Journal Article] Preoperatively reduced cerebrovascular contractile reactivity to hypocapnia by hyperventilation is associated with cerebral hyperperfusion syndrome after arterial bypass surgery for adult patients with cerebral misery perfusion due to ischemic moyamoya disease. (2018)
  • Author(s): Sato S, Kojima D, Shimada Y, Yoshida J, Fujimato K, Fujiwara S, Kobayashi M, Kubo Y, Yoshida K, Terasaki K, Tsutsui S, Miyoshi K, Ogasawara K.
  • Journal Title: J Cereb Blood Flow Metab Volume: 1 Issue: 6 Pages: 1021-1031
  • DOI: 10.1177/0271678x18757621
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Crossed cerebellar tracer uptake on acute-stage 123I-iomazenil SPECT imaging predicts 3-month functional outcome in patients with non-fatal hypertensive putaminal or thalamic hemorrhage (2018)
  • Author(s): Kojima D, Komoribayashi N, Omama S, Oikawa K, Fujiwara S, Kobayashi M, Kubo Y, Terasaki K, Ogasawara K
  • Journal Title: Clin Nucl Med Volume: 印刷中 Issue: 6 Pages: 396-401
  • DOI: 10.1097/rlu.0000000000002068
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preoperative brain temperature imaging on proton magnetic resonance spectroscopy predicts hemispheric ischemia during carotid endarterectomy for unilateral carotid stenosis with inadequate collateral blood flow (2018)
  • Author(s): Tsutsui Shouta、Nanba Takamasa、Yoshioka Yoshichika、Sasaki Makoto、Fujiwara Shunrou、Kobayashi Masakazu、Yoshida Kenji、Miyoshi Kenya、Sato Shinpei、Ogasawara Kuniaki
  • Journal Title: Neurological Research Volume: 印刷中 Pages: 1-7
  • DOI: 10.1080/01616412.2018.1457130
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of external carotid artery occlusion at declamping of the external and common carotid arteries during carotid endarterectomy on development of new postoperative ischemic cerebral lesions (2018)
  • Author(s): Kobayashi M, Yoshida K, Kojima D, Oshida S, Fujiwara S, Kubo Y, Ogasawara K
  • Journal Title: J Vasc Surg Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Two-year clinical, cerebral hemodynamic and cognitive outcomes of adult patients undergoing medication alone for symptomatically ischemic moyamoya disease without cerebral misery perfusion: a prospective cohort study Neurosurgery (2018)
  • Author(s): Miyoshi K, Chida K, Kobayashi M, Kubo Y, Yoshida K, Terasaki K, Ogasawara K
  • Journal Title: Neurosurgery Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Optimal Brain 99mTc-ECD SPECT Imaging and Analysis to Detect Misery Perfusion on 15O PET Imaging in Patients with Chronic Occlusive Disease of Unilateral Major Cerebral Artery (2017)
  • Author(s): Matsumoto Y, Oikawa K, Nomura J, Kojima D, Oshida S, Kobayashi M, Terasaki K, Kubo Y, Ogasawara K
  • Journal Title: Clin Nucl Med Volume: 42 Issue: 7 Pages: 499-505
  • DOI: 10.1097/rlu.0000000000001670
  • Peer Reviewed / Open Access
• [Journal Article] Preoperative cervical carotid artery contrast-enhanced ultrasound findings are associated with development of microembolic signals on transcranial Doppler during carotid exposure in endarterectomy (2017)
  • Author(s): Oikawa K, Kato T, Oura K, Narumi S, Sasaki S, Fujiwara S, Kobayashi M, Matsumoto Y, Nomura J, Yoshida K, Terayama Y, Ogasawara K
  • Journal Title: Atherosclerosis Volume: 260 Pages: 87-93
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Three-Dimensional T1-Weighted Magnetic Resonance and Contrast-Enhanced Ultrasound Plaque Images for Severe Stenosis of the Cervical Carotid Artery (2017)
  • Author(s): Shimada Y, Oikawa K, Fujiwara S, Ogasawara Y, Sato Y, Narumi S, Kato T, Oura K, Terayama Y, Sasaki M, Fujimoto K, Yoshida J, Ogasawara K
  • Journal Title: J Stroke Cerebvasc Dis Volume: 26 Pages: 1916-1922
  • Peer Reviewed
• [Journal Article] Apparent brain temperature imaging with multi-voxel proton magnetic resonance spectroscopy compared with cerebral blood flow and metabolism imaging on positron emission tomography in patients with unilateral chronic major cerebral artery steno-occlusive disease (2017)
  • Author(s): Nanba T, Nishimoto H, Yoshioka Y, Murakami T, Sasaki M, Uwano I, Fujiwara S, Terasaki K, Ogasawara K
  • Journal Title: Neuroradiology Volume: 59 Issue: 9 Pages: 923-935
  • DOI: 10.1007/s00234-017-1890-3
  • Peer Reviewed / Open Access
• [Journal Article] Preoperative Cerebral Oxygen Extraction Fraction Imaging Generated from 7T MR Quantitative Susceptibility Mapping Predicts Development of Cerebral Hyperperfusion following Carotid Endarterectomy. (2017)
  • Author(s): Nomura JI, Uwano I, Sasaki M, Kudo K, Yamashita F, Ito K, Fujiwara S, Kobayashi M, Ogasawara K.
  • Journal Title: AJNR Am J Neuroradiol. Volume: 38(12) Issue: 12 Pages: 499-505
  • DOI: 10.3174/ajnr.a5390
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preoperative cervical carotid artery contrast-enhanced ultrasound findings are associated with development of microembolic signals on transcranial Doppler during carotid exposure in endarterectomy. (2017)
  • Author(s): Oikawa K, Kato T, Oura K, Narumi S, Sasaki M, Fujiwara S, Kobayashi M, Matsumoto Y, Nomura JI, Yoshida K, Terayama Y, Ogasawara K.
  • Journal Title: Atherosclerosis Volume: 260 Pages: 87-93
  • DOI: 10.1016/j.atherosclerosis.2017.03.026
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Optimal Brain 99mTc-ECD SPECT Imaging and Analysis to Detect Misery Perfusion on 15O PET Imaging in Patients with Chronic Occlusive Disease of Unilateral Major Cerebral Artery. (2017)
  • Author(s): Matsumoto Y, Oikawa K, Nomura J, Kojima D, Oshida S, Kobayashi M, Terasaki K, Kubo Y, Ogasawara K.
  • Journal Title: Clin Nucl Med Volume: in press
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preoperative 3D FSE T1-Weighted MR Plaque Imaging for Severely Stenotic Cervical ICA: Accuracy of Predicting Emboli during Carotid Endarterectomy. (2016)
  • Author(s): Ogasawara Y, Sato Y, Narumi S, Sasaki M, Fujiwara S, Kobayashi M, Yoshida K, Terayama Y, Ogasawara K.
  • Journal Title: Int J Mol Sci Volume: 17
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cerebral Hyperperfusion after Revascularization Inhibits Development of Cerebral Ischemic Lesions Due to Artery-to-Artery Emboli during Carotid Exposure in Endarterectomy for Patients with Preoperative Cerebral Hemodynamic Insufficiency: Revisiting the "Impaired Clearance of Emboli" Concept. (2016)
  • Author(s): Fujimoto K, Matsumoto Y, Oikawa K, Nomura J, Shimada Y, Fujiwara S, Terasaki K, Kobayashi M, Yoshida K, Ogasawara K.
  • Journal Title: Int J Mol Sci Volume: 17 Issue: 8 Pages: 1261-1261
  • DOI: 10.3390/ijms17081261
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of uncomplicated carotid endarterectomy on cognitive function and brain perfusion in patients with unilateral asymptomatic severe stenosis of the internal carotid artery by comparison with unoperated patients (2016)
  • Author(s): Kojima D, Ogasawara K, Kobayashi M, Yoshida K, Kubo Y, Chida K, Oshida S, Yoshida J, Fujiwara S, Terasaki K
  • Journal Title: Neurol Res Volume: 7 Issue: 7 Pages: 580-6
  • DOI: 10.1080/01616412.2016.1188551
  • Peer Reviewed
• [Journal Article] Effects of Uncomplicated Carotid Endarterectomy on Cognitive Function and Brain Perfusion in Patients with Unilateral Asymptomatic Severe Stenosis of the Internal Carotid Artery by Comparison with Unoperated Patients (2016)
  • Author(s): Kojima D, Ogasawara K, Kobayashi M, Yoshida K, Kubo Y, Chida K, Oshida S, Yoshida J, Fujiwara S, Terasaki K
  • Journal Title: Neurol Res Volume: NA
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Preoperative prediction of cerebral hyperperfusion after carotid endarterectomy using middle cerebral artery signal intensity in 1.5-tesla magnetic resonance angiography followed by cerebrovascular reactivity to acetazolamide using brain perfusion single-photon emission computed tomography. (2016)
  • Author(s): Yoshida J, Ogasawara K, Chida K, Oikawa K, Matsumoto Y, Nomura J, Ogasawara Y, Fujiwara S, Kobayashi M, Yoshida K, Terasaki K, Ogawa A.
  • Journal Title: Neurol Res Volume: 38 Issue: 1 Pages: 1-9
  • DOI: 10.1080/01616412.2015.1114291
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Optimal MR Plaque Imaging for Cervical Carotid Artery Stenosis in Predicting the Development of Microembolic Signals during Exposure of Carotid Arteries in Endarterectomy: Comparison of 4 T1-Weighted Imaging Techniques. (2016)
  • Author(s): Sato Y, Ogasawara K, Narumi S, Sasaki M, Saito A, Tsushima E, Namba T, Kobayashi M, Yoshida K, Terayama Y, Ogawa A.
  • Journal Title: AJNR Am J Neuroradiol Volume: NA
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 頚動脈内膜剥離術の要点 (2018)
  • Author(s): 小笠原邦昭
  • Organizer: 第47回日本脳卒中の外科学会学術集会
  • Invited
• [Presentation] 頚部内頚動脈狭窄症に対する血行再建術の認知機能に与える影響 (2018)
  • Author(s): 小笠原邦昭
  • Organizer: STROKE2018
  • Invited
• [Presentation] Detection of misery perfusion in patients with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion on 123I-IMP single-photon emission computed tomography imaging (2017)
  • Author(s): Matsumoto Y., Ogasawara K., Saito H., Terasaki K., Takahashi Y., Ogasawara Y., Kobayashi M., Yoshida Kenji., Beppu T., Kubo Y., Fujiwara .1, *Tsushima
  • Organizer: Berlin BRAIN＆BRAIN PET 2017
  • Place of Presentation: Berlin
  • Year and Date: 2017-04-01
  • Int'l Joint Research
• [Presentation] Prediction of new cerebral ischemic events after endarterectomy for symptomatic unilateral internal carotid artery stenosis using crossed cerebellar hypoperfusion on preoperative brain perfusion (2017)
  • Author(s): Oikawa K., Ogasawara K., Saito H., Yoshida Kenji., Saura H., Sato Y., Terasaki K., Wada T., Kubo Y.
  • Organizer: Berlin BRAIN＆BRAIN PET 2017
  • Place of Presentation: Berlin
  • Year and Date: 2017-04-01
  • Int'l Joint Research
• [Presentation] 頚動脈狭窄症に対する外科治療は何が進歩したのか (2017)
  • Author(s): 小笠原邦昭
  • Organizer: STROKE2017 (第46回日本脳卒中の外科学会学術集会)
  • Place of Presentation: 大阪
  • Year and Date: 2017-03-16
  • Invited
• [Presentation] 一側性脳主幹動脈閉塞性病変に対する99mTc-ECD SPECTの貧困灌流検出 (2017)
  • Author(s): 松本昌泰、千田光平、及川公樹、小島大吾、藤原俊朗、小林正和、吉田研二、小笠原邦昭
  • Organizer: STROKE2017 (第46回日本脳卒中の外科学会学術集会)
  • Place of Presentation: 大阪
  • Year and Date: 2017-03-16
• [Presentation] 頚動脈内膜剥離術中の微小塞栓出現の術前予知：頚動脈造影超音波検査による検討 (2017)
  • Author(s): 及川公樹、千田光平、藤原俊朗、鳴海新介、大浦一雅、小笠原邦昭
  • Organizer: STROKE2017 (第46回日本脳卒中の外科学会学術集会)
  • Place of Presentation: 大阪
  • Year and Date: 2017-03-16
• [Presentation] 術前7Tesla定量的磁化率マップ(QSM)によるOEF画像を用いた頸動脈内膜剥離術後過灌流出現の予知 (2017)
  • Author(s): 野村順一、松本昌泰、及川公樹、大志田創太郎、小島大吾、千田光平、小林正和、上野育子、佐々木真理、小笠原邦昭
  • Organizer: STROKE2017 (第46回日本脳卒中の外科学会学術集会)
  • Place of Presentation: 大阪
  • Year and Date: 2017-03-16
• [Presentation] 頚動脈内膜剥離術後過灌流は術中塞栓による脳虚血巣の出現を抑える：Wash out仮説の拡大解釈 (2017)
  • Author(s): 小林正和、小笠原邦昭、及川公樹、松本昌泰、小島大吾、吉田研二、藤原俊朗
  • Organizer: STROKE2017 (第46回日本脳卒中の外科学会学術集会)
  • Place of Presentation: 大阪
  • Year and Date: 2017-03-16
• [Presentation] 脳血流SPECTにおけるCrossed Cerebellar Diaschisisの臨床意義 (2017)
  • Author(s): 小笠原邦昭
  • Organizer: 第60回日本脳循環代謝学会学術集会
  • Invited
• [Presentation] 脳血管障害における脳SPECTはこう使う!! (2017)
  • Author(s): 小笠原邦昭
  • Organizer: 第57回日本核医学会学術総会
  • Invited
• [Presentation] 高齢者頚部頚動脈狭窄症に対する外科的血行再建術 (2017)
  • Author(s): 小笠原邦昭
  • Organizer: 第4回日本心血管脳卒中学会学術集会
• [Presentation] 脳血管障害における脳血流SPECT画像はこう読む!! (2017)
  • Author(s): 小笠原邦昭
  • Organizer: 第37回日本脳神経外科コングレス総会
• [Presentation] 頸部頸動脈血行再建術後過灌流予知における頭部MRAの有用性とacetazolamide負荷脳血流SPECT施行の効率化 (2016)
  • Author(s): 千田光平、小林正和、吉田研二、小笠原邦昭
  • Organizer: 第45回日本脳卒中の外科学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2016-04-14
• [Presentation] ACZ適正使用指針を踏まえた有効な負荷脳血流SPECT (2016)
  • Author(s): 小笠原邦昭
  • Organizer: 第41回日本脳卒中学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2016-04-14
  • Invited
• [Presentation] 脳梗塞慢性期の外科治療 (EC-IC Bypass) (2016)
  • Author(s): 小笠原邦昭
  • Organizer: 第41回日本脳卒中学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2016-04-14
  • Invited
• [Presentation] 頸動脈内膜剥離術中の微小塞栓出現の術前予知：3D T1W MRプラークイメージングによる検討 (2016)
  • Author(s): 小笠原靖、小笠原邦昭、鳴海新介、藤原俊朗、佐藤由衣子、吉田研二、小林正和、佐々木真理、寺山靖夫、小川 彰
  • Organizer: 第39回日本脳神経CI学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-01-29
• [Presentation] 頸動脈内膜剥離術後過灌流予知におけるacetazolamide負荷脳血流SPECTの精度と頭部MRAによるスクリーニング (2016)
  • Author(s): 千田光平、及川公樹、松本昌泰、野村順一、小笠原靖、小林正和、吉田研二、小笠原邦昭
  • Organizer: 第39回日本脳神経CI学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-01-29
  • Invited
• [Presentation] Hypoxic viable tissue in human chronic cerebral ischemia (2015)
  • Author(s): Saura H, Ogasawara K
  • Organizer: The 7th Japanese-Korean Joint Stroke Conference
  • Place of Presentation: 韓国・釜山
  • Year and Date: 2015-10-22
  • Int'l Joint Research
• [Presentation] Post-carotid endarterectomy changes of cerebral (2015)
  • Author(s): Yoshida K, Ogasawara K
  • Organizer: The 7th Japanese-Korean Joint Stroke Conference
  • Place of Presentation: 韓国・釜山
  • Year and Date: 2015-10-22
  • Int'l Joint Research
• [Presentation] Preoperative prediction of cerebral hyperperfusion after (2015)
  • Author(s): Chida K, Ogasawara K
  • Organizer: The 7th Japanese-Korean Joint Stroke Conference
  • Place of Presentation: 韓国・釜山
  • Year and Date: 2015-10-22
  • Int'l Joint Research
• [Presentation] Assessment of brain temperture and white matter damage in subacute carbon monoxide poisned patients using diffusion tensor imaging (2015)
  • Author(s): Fujiwara S, Yoshioka Y, Matsuda T, Nishimoto H, Murakami T, Ogasawara K, Beppu T
  • Organizer: 38th ESNR Annual Meeting
  • Place of Presentation: Naples, Italy
  • Year and Date: 2015-09-17
  • Int'l Joint Research