Project of malignant glioma cell absorption therapy and plasmin therapy
| Project/Area Number |
15K10325
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Hirosaki University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 悪性グリオーマ / 細胞吸着療法 / プラスミン融解療法 / glioma / plasmin / プロティオグリカン / 人工基質 / プラスミン / 細胞融解 / 細胞吸着 |
|---|
| Outline of Final Research Achievements |
If we would protect glioma cell invasion and gather one part, we could threat them more effective. After proteoglycan artificial matrix with molecular target medicine AG1478 were completed, tumor cells were absorbed in artificial matrix. After that we would inject plasmin to artificial matrix composed fibrin mainly and melted out, we would treated malignant glioma completely without radiation therapy. We planed the theory of this new strategy.
We found out that the concentration of plasmin would need 10.0M high concentration, and needed the two step injections of 2.0M concentration in 14 and 16 post operation day. And so, this new strategy reviled good result and long survival OS 91 days. However, a couple of dissemination recurrence case and distant recurrence case were seen, so we need to explore of these new recurrence patterns.
|
Report
(4 results)
Research Products
(1 results)
