A study of new treatment by JAK-STAT inhibition for central nervous system lymphoma
| Project/Area Number |
15K10332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
篠山 隆司 神戸大学, 医学部附属病院, 講師 (10379399)
田中 一寛 神戸大学, 医学研究科, 特定助教 (70467661)
水川 克 神戸大学, 医学部附属病院, 非常勤講師 (80403260)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | lymphoma / JAK / STAT / IL-10 / CNS / JAK-STAT / 中枢神経悪性リンパ腫 / STAT3 / primary CNS lymphoma |
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| Outline of Final Research Achievements |
Cerebrospinal fluid (CSF) interleukin-10 (IL-10) level was associated with activation level of JAK-STAT pathway in central nervous system lymphoma (PCNSL). PCNSL with high CSF IL-10 had strong expression of PIN-1 and SOCS, downstream molecules of JAK-STAT pathway. In addition, CSF IL-10 levels were associated with infiltration levels of tumor associated macrophages (TAMs) in PCNSL. When IL-10 protein was injected into inoculated subcutaneous PCNSL tumor of mouse, JAK and STAT3 in tumor cells was phosphorylated and activated by IL-10. But, JAK/STAT inhibitors could not show a antitumor effect in mouse models.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma.2018
Author(s)
Nagashima H, Sasayama T, Tanaka K, Kyotani K, Sato N, Maeyama M, Kohta M, Sakata J, Yamamoto Y, Hosoda K, Itoh T, Sasaki R, Kohmura E.
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Journal Title
J Neurooncol.
Volume: 136
Issue: 2
Pages: 317-326
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Tumor-Associated Macrophages Associate with Cerebrospinal Fluid Interleukin-10 and Survival in Primary Central Nervous System Lymphoma (PCNSL)2015
Author(s)
Sasayama T, Tanaka K, Mizowaki T, Nagashima H, Nakamizo S, Tanaka H, Nishihara M, Mizukawa K, Hirose T, Itoh T, Kohmura E
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Journal Title
Brain Pathol.
Volume: Aug 28
Issue: 4
Pages: 1-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Combined IDH1 mutation and MGMT methylation status on long-term survival of patients with cerebral low-grade glioma.2015
Author(s)
Tanaka K, Sasayama T, Mizukawa K, Takata K, Sulaiman NS, Nishihara M, Kohta M, Sasaki R, Hirose T, Itoh T, Kohmura E.
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Journal Title
Clin Neurol Neurosurg.
Volume: 138
Pages: 37-44
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] STAT3 activation is associated with cerebrospinal fluid interleukin-10 (IL-10) in primary central nervous system diffuse large B cell lymphoma.2015
Author(s)
Mizowaki T, Sasayama T, Tanaka K, Mizukawa K, Takata K, Nakamizo S, Tanaka H, Nagashima H, Nishihara M, Hirose T, Itoh T, Kohmura E
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Journal Title
J Neurooncol
Volume: 124(2)
Issue: 2
Pages: 165-74
DOI
Related Report
Peer Reviewed
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