Identification of new molecular target associated with treatment-resistance of glioblastomas
| Project/Area Number |
15K10349
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
IUCHI TOSHIHIKO 千葉県がんセンター(研究所), 脳神経外科, 部長 (80370881)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | glioblastoma / radiation / chemotherapy / resistance / molecular target / DNA repair / 神経膠芽腫 / 放射線治療 / 化学療法 / 遺伝子発現 / 治療抵抗性 / 分子標的 / テモゾロミド / IMRT / CTOS / MGMT / 1p/19q今日欠失 / IDH / 1p/19q共欠失 |
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| Outline of Final Research Achievements |
Copy number decrease of Rad51 (an essential factor of homologous recombination:HR) and XRCC6 (coding Ku70 which acts as the cornerstone of the non-homologous end joining: NHEJ) were associated with the survival of patients after chemo-radiotherapy, and were suspected to be a key molecule of tumor resistance to the treatment. However, from the comparative study of gene expression profiles between the samples from tumors pre- and just post-chemo-radiotherapy, genes involved in HR and NHEJ were down-regulated by the treatment, while CDKN1A and DDB2 expressions were up-regulated in the all cases. These data suggested the significant role of cell cycle arrest by CDKN1A and nucleotide excision repair, not HR nor NHEJ, plays a major role in tumor resistance to chemo-radiotherapy in glioblastomas.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] A prospective, multicentre, single-arm clinical trial of bevacizumab for patients with surgically untreatable, symptomatic brain radiation necrosis.2016
Author(s)
Furuse M, Nonoguchi N, Kuroiwa T, Miyamoto S, Arakawa Y, Shinoda J, Miwa K, Iuchi T, Tsuboi K, Houkin K, Terasaka S, Tabei Y, Nakamura H, Nagane M, Sugiyama K, Terasaki M, Abe T, Narita Y, Saito N, Mukasa A, Ogasawara K, Beppu T, Kumabe T, Nariai T, Tsuyuguchi N, Nakatani E, Kurisu S, Nakagawa Y, Miyatake SI.
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Journal Title
Neurooncol Pract.
Volume: 3
Pages: 272-280
Related Report
Peer Reviewed
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[Journal Article] Frequency of brain metastases in non-small-cell lung cancer and their association with epidermal growth factor receptor mutations.2015
Author(s)
Toshihiko Iuchi, Masato Syngyoji, Meiji Itakura, Sana Yokoi, Yasumitsu Moriya, Hajime Tamura, Yasushi Yoshida, Hironori Ashinuma, Koichiro Kawasaki, Yuzo Hasegawa, Tsukasa Sakaida.
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Journal Title
Int J Clin Oncol
Volume: 20
Issue: 4
Pages: 674-679
DOI
Related Report
Peer Reviewed
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[Journal Article] Human Chorionic Gonadotropin is Expressed Virtually in All Intracranial Germ Cell Tumors.2015
Author(s)
Takami H, Fukushima S, Fukuoka K, Suzuki T, Yanagisawa T, Matsushita Y, Nakamura T, Arita H, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, et al.
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Journal Title
J Neurooncol
Volume: 124
Issue: 1
Pages: 23-32
DOI
Related Report
Peer Reviewed
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[Presentation] 神経膠腫疑い患者に対するPET新規アミノ酸トレーサー 18F-fluciclovine の有効性及び安全性：多施設共同前向き臨床試験2016
Author(s)
若林俊彦, 井内俊彦, 露口尚弘, 西川亮, 荒川芳輝, 篠山隆司, 三宅啓介, 成相直, 成田善孝, 橋本直哉, 屋田修, 松田博史, 窪田和雄, 伊藤公輝, 中里洋一, 久保村幹細
Organizer
日本脳神経外科学会第75回学術総会
Place of Presentation
福岡
Year and Date
2016-09-28
Related Report
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