| Project/Area Number |
15K10356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Shinshu University |
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Principal Investigator |
Kiyoshi Ito 信州大学, 学術研究院医学系(医学部附属病院), 講師 (00362111)
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| Co-Investigator(Kenkyū-buntansha) |
川原 一郎 松本歯科大学, 歯学部, 教授 (20319114)
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| Research Collaborator |
MORI Kazutaka
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 高分子化合物 / ポリエーテルエーテルケトン / 骨伝導性 / 骨形成能 / インプラント / 頚椎症 / 骨形成性 / PEEK / 変性疾患 / 骨形成 / フッ素化 |
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| Outline of Final Research Achievements |
An experiment was conducted to enhance the bone conductivity by fluorinating the surface of the PEEK material. Therefore, it was found that bone conduction can be enhanced by adjusting the fluorine gas partial pressure of the fluorine / oxygen mixed gas and the processing time. However, under the actual processing conditions, the shape of PEEK (Cylinder was the necessary requirement for final implantation in rabbits and in vivo experiments. In vitro, plate-like PEEK was used.) It was found that the condition of surface processing was affected. Although the conditions of the surface fluorination can not be specifically described from the relationship of the patent submitted recently, it was possible to study the conditions which cause the surface to be negatively ionized in vivo and to gather more calcium ions.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、本来骨伝導性をもつ可能性が低い、高分子化合物をフッ素化することにより、骨伝導性を付加することができることが証明され、引いては、脊椎疾患インプラントのみではなく、足関節、膝関節などのインプラントへの応用が可能となる可能性が示された。
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