| Project/Area Number |
15K10365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 淳平 札幌医科大学, 医学部, 研究員 (00572596)
佐々木 祐典 札幌医科大学, 医学部, 講師 (20538136)
中崎 公仁 札幌医科大学, 医学部, 研究員 (70722461)
鰐渕 昌彦 札幌医科大学, 医学部, 准教授 (30343388)
三上 毅 札幌医科大学, 医学部, 講師 (30372816)
小野寺 理恵 札幌医科大学, 医学部, 講師 (60393328)
浪岡 隆洋 札幌医科大学, 医学部, 研究員 (70748996)
浪岡 愛 札幌医科大学, 医学部, 研究員 (60748995)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経再生 / 骨髄間葉系幹細胞 / 可塑性 / diffusion MRI / 再生医療 / diffusion tensor imaging / tractography / 神経再生医療学 / 脳神経外科学 |
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| Outline of Final Research Achievements |
Intravenous infusion of mesenchymal stem cells (MSCs) improves behavioral function in rat stroke models. MRI Diffusion tensor imaging tractography demonstrated that increasedmore “number of tracks” was observed in the MSC-treated group compared to the non-treated group. The number of synaptic puncta in non-infarcted the cortex in the MSC-treated group was higher than the non-treated group. Corpus callosum thickness was greater in the MSC-treated group than the non-treated group. These results suggested enhanced plasticity was occurred following intravenous infusion of MSCs in cerebral infarction. It is conceivable that these processmechanisms might contribute to functional improvement by the infused MSCs in strokefrom cerebral infarction.
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