| Project/Area Number |
15K10377
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Meiji University of Integrative Medicine |
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Principal Investigator |
Higuchi Toshihiro 明治国際医療大学, 医学教育研究センター, 教授 (80218700)
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| Co-Investigator(Kenkyū-buntansha) |
梅田 雅宏 明治国際医療大学, 医学教育研究センター, 教授 (60223608)
田中 忠蔵 明治国際医療大学, 医学教育研究センター, 名誉教授 (80163541)
渡邉 康晴 明治国際医療大学, 医学教育研究センター, 講師 (90454537)
河合 裕子 明治国際医療大学, 医学教育研究センター, 助教 (90555616)
村瀬 智一 明治国際医療大学, 医学教育研究センター, 客員助教 (00708943)
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| Research Collaborator |
FUKUNAGA Masaki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳代謝 / 酸化ストレス / GSH / 脳 / MRS |
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| Outline of Final Research Achievements |
Oxidative stress plays an important role in brain aging, neurodegenerative diseases, and other related adverse conditions, such as ischemia. On the other hand, antioxidants such as Glutathione (GSH) is critical for protecting the brain from oxidative stress. It is present in micromolar concentrations in bodily fluids and in millimolar concentrations in tissue. In this study, we will use magnetic resonance spectroscopic imaging to map antioxidants. Magnetic resonance spectroscopic imaging (MRSI) is a noninvasive imaging method and reveals a wealth of metabolic information.
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