Formulation of clinical standards regarding patient and device selection for acute stroke thrombectomy
Project/Area Number |
15K10381
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | University of Tsukuba (2017-2018) National Cardiovascular Center Research Institute (2015-2016) |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 急性期脳梗塞 / 血管内治療 / 血栓回収療法 / 脳主幹動脈閉塞 / 可逆的拡散強調画像高信号 / 頭蓋内出血 / 血栓病理 / CT-DWI mismatch / ステントリトリーバー |
Outline of Final Research Achievements |
In recent years, the efficacy of stroke thrombectomy has been established to improve functional outcome. There are, however, several unclear points regarding patient or device selection for acute stroke thrombectomy. We showed new insights regarding stroke thrombectomy from this study. Firstly, the intrainfarct FLAIR hyperintensity itself and its relative signal intensity might predict post-thrombectomy intracranial hemorrhage. Secondly, the sum of angles of the stent-retriever passing vessels were associated with the occurrence of post-thrombectomy subarachnoid hemorrhage. Thirdly, successful reperfusion after stroke thrombectomy could be associated with the histopathology of retrieved thrombi. Lastly, interhospital transfer to endovascular-capable center was associated with lower chance of favorable clinical outcome compared with direct admission. These insights can contribute to develop the standards of patient or device selection for acute stroke thrombectomy.
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Academic Significance and Societal Importance of the Research Achievements |
本研究から得られた、急性期脳主幹動脈閉塞に対する血管内治療の有効性・安全性に関する各成果は、血管内治療の適応判定(症例選択・デバイス/手技選択)基準の策定に貢献するものであり、当該治療の成績向上を通して、わが国の急性期脳主幹動脈閉塞例全体の転帰改善に寄与すると考えられる。
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Report
(5 results)
Research Products
(42 results)
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[Presentation] 血栓回収療法を受けた急性期脳主幹動脈閉塞例における搬送様式と転帰の関連:RICOVERY Retrospective study2018
Author(s)
早川幹人, 佐藤允之, 芳村雅隆, 鶴見有史, 河合拓也, 粕谷泰道, 大橋智生, 大島幸亮, 伊藤嘉朗, 丸島愛樹, 加藤徳之, 松丸祐司.
Organizer
第34回NPO法人日本脳神経血管内治療学会学術総会
Related Report
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[Presentation] Factors Associated with the vascular wall component in the endovascularly-retrieved thrombi in acute stroke patients.2017
Author(s)
Funatsu N, Hayakawa M, Hashimoto T, Fujita K, Iwasaki Y, Yamagami H, Satow T, Takahashi JC, Ihara M, Ishibashi-Ueda H, Iwama T, Toyoda K.
Organizer
3rd European Stroke Organization Conference
Related Report
Int'l Joint Research
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[Presentation] 血栓回収療法により得られた検体中の血管壁成分についての検討2016
Author(s)
船津奈保子, 早川幹人, 橋本哲也, 藤田恭平, 岩崎優子, 山上宏, 佐藤徹, 髙橋淳, 長束一行, 植田初江, 豊田一則
Organizer
第32回日本脳神経血管内治療学会学術総会
Place of Presentation
神戸
Year and Date
2016-11-24
Related Report
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[Presentation] 梗塞巣内のFLAIR relative signal intensityは血管内治療による急性再開通療法後の頭蓋内出血を予測する2016
Author(s)
吉本武史, 早川幹人, 山上宏, 船津奈保子, 園田和隆, 日野天佑, 塩澤真之, 奥野善教, 佐藤徹, 高橋淳, 長束一行, 豊田一則
Organizer
第32回日本脳神経血管内治療学会学術総会
Place of Presentation
神戸
Year and Date
2016-11-24
Related Report
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[Presentation] Stent retrieverによる血栓回収術後のくも膜下出血に関する検討2016
Author(s)
早川幹人, 山上宏, 船津奈保子, 園田和隆, 吉本武史, 塩澤真之, 日野天祐, 奥野善教, 佐藤徹, 高橋淳, 長束一行, 豊田一則
Organizer
第32回日本脳神経血管内治療学会学術総会
Place of Presentation
神戸
Year and Date
2016-11-24
Related Report
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