The effect of bone metabolism on the development of adolescent idiopathic scoliosis.

• Project/Area Number: 15K10413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Yokohama City University
• Principal Investigator: AOTA Yoichi 横浜市立大学, 医学研究科, 客員教授 (40363824)
• Research Collaborator: TANABE Hironori ; ITO Akemi
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 思春期特発性側弯症 / 骨粗鬆症 / ビスフォスフォネート / C57BL6Jマウス / マウス / 破骨細胞 / 骨代謝

Outline of Final Research Achievements

Recent studies have shown an association between osteopenia and adolescent idiopathic scoliosis (AIS) and implied that osteopenia plays a causative role in AIS development. This study aimed to determine if minodronate (MIN) treatment could prevent curve progression by increasing bone mass in a thoracic restraint (TR) mouse model, which develops causes the development of thoracic scoliosis similar to human AIS. TR induced osteoporosis with accelerated bone resorption. MIN improved improved poor bone structure. MIN significantly reduced the curve magnitudes. The administration of MIN increased bone mass and reduced the severity of scoliosis in the TR mice. MIN was suggested as a possible inhibitor of scoliosis development.

Research Products

• [Journal Article] A histomorphometric study of the cancellous spinal process bone in adolescent idiopathic scoliosis. (2017)
  • Author(s): Tanabe H, Aota Y, Nakamura N, Saito T.
  • Journal Title: Eur Spine J Volume: 1 Issue: 6 Pages: 1600-1609
  • DOI: 10.1007/s00586-017-4974-1
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Entrapment of middle cluneal nerves as an unknown cause of low back pain. (2016)
  • Author(s): Aota Y.
  • Journal Title: World J Orhop Volume: 18 Issue: 3 Pages: 167-70
  • DOI: 10.5312/wjo.v7.i3.167
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Validation study of arm positions for evaluation of global spinal balance in EOS imaging. (2016)
  • Author(s): Kaneko K, Aota Y, Sekiya T, Yamada K, Saito T.
  • Journal Title: Eur J Orthop Surg Traumatol Volume: 26 Issue: 7 Pages: 725-33
  • DOI: 10.1007/s00590-016-1813-8
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Laminar screw fixation in the subaxial cervical spine: A report on three cases. (2016)
  • Author(s): Tanabe H, Aota Y, Saito T.
  • Journal Title: World J Orthop Volume: 18 Issue: 10 Pages: 695-99
  • DOI: 10.5312/wjo.v7.i10.695
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Minodronate Treatment Improves Bone Loss and Reduces Progressive Thoracic Scoliosis (2016)
  • Author(s): Tanabe H, Aota , Yamaguchi Y, Kaneko K, Imai S, Takahashi M, Taguri M, Saito T
  • Organizer: 日本側弯症学会
  • Place of Presentation: 国立京都国際会館（京都市左京区）
  • Year and Date: 2016-11-17
• [Presentation] A Hisitomorphometic Study of the Cancellous Spinal Process Bone (2016)
  • Author(s): anabe H, Aota , Nakamura N, Saito T
  • Organizer: 日本側弯症学会
  • Place of Presentation: 国立京都国際会館（京都市左京区）
  • Year and Date: 2016-11-17
• [Presentation] 思春期特発性側弯症における骨形態計測法を用いた骨代謝評価 (2016)
  • Author(s): 田辺博宣、青田洋一、中村直行、斎藤知行
  • Organizer: 日本骨粗鬆症学会
  • Place of Presentation: 仙台勝山館 （仙台市青葉区）
  • Year and Date: 2016-10-06