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The effect of bone metabolism on the development of adolescent idiopathic scoliosis.

Research Project

Project/Area Number 15K10413
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionYokohama City University

Principal Investigator

AOTA Yoichi  横浜市立大学, 医学研究科, 客員教授 (40363824)

Research Collaborator TANABE Hironori  
ITO Akemi  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords思春期特発性側弯症 / 骨粗鬆症 / ビスフォスフォネート / C57BL6Jマウス / マウス / 破骨細胞 / 骨代謝
Outline of Final Research Achievements

Recent studies have shown an association between osteopenia and adolescent idiopathic scoliosis (AIS) and implied that osteopenia plays a causative role in AIS development. This study aimed to determine if minodronate (MIN) treatment could prevent curve progression by increasing bone mass in a thoracic restraint (TR) mouse model, which develops causes the development of thoracic scoliosis similar to human AIS. TR induced osteoporosis with accelerated bone resorption. MIN improved improved poor bone structure. MIN significantly reduced the curve magnitudes. The administration of MIN increased bone mass and reduced the severity of scoliosis in the TR mice. MIN was suggested as a possible inhibitor of scoliosis development.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (3 results)

  • [Journal Article] A histomorphometric study of the cancellous spinal process bone in adolescent idiopathic scoliosis.2017

    • Author(s)
      Tanabe H, Aota Y, Nakamura N, Saito T.
    • Journal Title

      Eur Spine J

      Volume: 1 Issue: 6 Pages: 1600-1609

    • DOI

      10.1007/s00586-017-4974-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Entrapment of middle cluneal nerves as an unknown cause of low back pain.2016

    • Author(s)
      Aota Y.
    • Journal Title

      World J Orhop

      Volume: 18 Issue: 3 Pages: 167-70

    • DOI

      10.5312/wjo.v7.i3.167

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Validation study of arm positions for evaluation of global spinal balance in EOS imaging.2016

    • Author(s)
      Kaneko K, Aota Y, Sekiya T, Yamada K, Saito T.
    • Journal Title

      Eur J Orthop Surg Traumatol

      Volume: 26 Issue: 7 Pages: 725-33

    • DOI

      10.1007/s00590-016-1813-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Laminar screw fixation in the subaxial cervical spine: A report on three cases.2016

    • Author(s)
      Tanabe H, Aota Y, Saito T.
    • Journal Title

      World J Orthop

      Volume: 18 Issue: 10 Pages: 695-99

    • DOI

      10.5312/wjo.v7.i10.695

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Minodronate Treatment Improves Bone Loss and Reduces Progressive Thoracic Scoliosis2016

    • Author(s)
      Tanabe H, Aota , Yamaguchi Y, Kaneko K, Imai S, Takahashi M, Taguri M, Saito T
    • Organizer
      日本側弯症学会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] A Hisitomorphometic Study of the Cancellous Spinal Process Bone2016

    • Author(s)
      anabe H, Aota , Nakamura N, Saito T
    • Organizer
      日本側弯症学会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 思春期特発性側弯症における骨形態計測法を用いた骨代謝評価2016

    • Author(s)
      田辺博宣、青田洋一、中村直行、斎藤知行
    • Organizer
      日本骨粗鬆症学会
    • Place of Presentation
      仙台勝山館 (仙台市青葉区)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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