| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
The regenerative capacity of skeletal muscle relies largely on the presence of muscle stem cells, called muscle satellite cells. The capacity for proliferation and/or differentiation of muscle satellite cells is assumed to decline in elderly perspons because the regenerative capacity of muscle decreases during aging. To reveal the age-dependent changes of muscle satellite cells, we have established immortalized human myogenic cell lines derived from muscle satellite cells of young and elderly persons. Immortalized human myogenic cells preserved high capacity for proliferation and/or differentiation independently of the age. The results suggest that the muscle of elderly persons still reserves functional muscle stem cells.
|
