Development of fragility fracture treatment using molecular evolution engineering

• Project/Area Number: 15K10445
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: Watanabe Noriyuki 岡山大学, 医学部, 客員研究員 (80708107)
• Co-Investigator(Kenkyū-buntansha): 尾崎 敏文 岡山大学, 医歯薬学総合研究科, 教授 (40294459) ; 松川 昭博 岡山大学, 医歯薬学総合研究科, 教授 (90264283)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 生体材料 / チタン結合性BMP / リン酸化プルラン / チタン結合性ＢＭＰ

Outline of Final Research Achievements

We investigated the availability of a titanium binding bone morphologic protein(TB-BMP), which is a new biological material. TB-BMP coating titanium wires and conventional titanium wires were implanted in the femur of rats. TB-BMP coating titanium wires significantly enhanced bone formation on the surface of titanium compared to conventional titanium wires. Pull-out strength was also significantly increased in TB-BMP group. These results suggest that TB-BMP is a useful material for the treatment for the osteoporotic patients.

Research Products

• [Presentation] ラットにおけるチタン結合性BMPの骨形成促進効果についての検討 (2018)
  • Author(s): 内野崇彦、塩崎泰之、吉田晶、宇川諒、池田吉宏、村岡聡介、辻寛謙、野田知之、伊藤嘉浩、松川昭博、尾﨑敏文
  • Organizer: 第33回日本整形外科学会基礎学術集会
• [Presentation] ラットにおけるチタン結合性BMPの骨形成促進効果についての検討 (2017)
  • Author(s): 内野崇彦、塩崎泰之、吉田晶、吉村将秀、宇川諒、池田吉宏、村岡聡介、伊藤嘉浩、松川昭博、尾﨑敏文
  • Organizer: 第37回整形外科バイオマテリアル研究会