Establishment of early diagnosis and treatment in the patient with the surgical site infection

• Project/Area Number: 15K10457
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: International University of Health and Welfare (2017); Keio University (2015-2016)
• Principal Investigator: ISHII KEN 国際医療福祉大学, 医学部, 主任教授 (00276289)
• Co-Investigator(Renkei-kenkyūsha): AIZAWA MAMORU 明治大学, 理工学部, 教授 (10255713) ; OKADA YASUNORI 順天堂大学, 医学部, 客員教授 (00115221)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 骨軟部組織 / 感染症 / インプラント関連感染症 / メタボローム解析 / インプラント関連感染

Outline of Final Research Achievements

Osteomyelitis which is often caused from surgical site infection is a serious problem in orthopedic surgery. Although several candidates of osteomyelitis biomarkers were investigated, potential specific biomarkers for diagnosis of osteomyelitis have not been detected yet. Here, we examined the metabolome analysis (ＣＥ－ＴＯＦＭＳ,ＬＣ－ＴＯＦＭＳ)to detect specific plasma biomarkers of osteomyelitis using mouse osteomyelitis model. 279 metabolites were detected by the metabolome analyses. Principal component analysis showed that both sphingosine and sphinganine were detected as the highest loading factors.

Research Products

• [Journal Article] Predictors of hospital readmission and surgical site infection in the United States, Denmark, and Japan: Is risk stratification a universal language? (2017)
  • Author(s): Glassman S, Carreon L, Anderson M, Asher A, Eiskjaer S, Gehrchen M, Imagama S, Ishii K, Kaito T, Matsuyama Y, Moridaira H, Mummaneni P, Shaffrey C, Matsumoto M
  • Journal Title: Spine Volume: 42(17) Issue: 17 Pages: 1311-1315
  • DOI: 10.1097/brs.0000000000002082
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Risk Factors for Delirium After Spine Surgery in Extremely Elderly Patients Aged 80 Years or Older and Review of the Literature: Japan Association of Spine Surgeons with Ambition Multicenter Study (2017)
  • Author(s): Kobayashi Kazuyoshi、Imagama Shiro、Ando Kei、Ishiguro Naoki、Yamashita Masaomi、Eguchi Yawara、Matsumoto Morio、Ishii Ken、Hikata Tomohiro、Seki Shoji、Ohtori Seiji
  • Journal Title: Global Spine Journal Volume: 7 Issue: 6 Pages: 560-566
  • DOI: 10.1177/2192568217700115
  • NAID: 120007134634
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Correlation between preoperative physical signs and functional outcomes after laminoplasty for ossification of the posterior longitudinal ligament (2017)
  • Author(s): Tsuji T, Fujita N, Watanabe K, Nakamura M, Matsumoto M, Ishii K
  • Journal Title: J Orthop Sci Volume: 22(2) Issue: 2 Pages: 266-269
  • DOI: 10.1016/j.jos.2016.12.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Imaging comparison between Chinese and Japanese patients with cervical ossification of the posterior longitudinal ligament (2017)
  • Author(s): Xiao B, Nagoshi N, Takeuchi A, Mao J, Liu B, Tian W, Tsuji O, Okada E, Fujita N, Yagi M, Nakamura M, Matsumoto M, Ishii K, Watanabe K
  • Journal Title: Spine Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Utilization of a technique of percutaneous S2 alar-iliac fixiation in immunocompromised patients with spondylodiscitis (2017)
  • Author(s): Funao H, Kebaish K, Isogai N, Koyanagi T, Matsumoto M, Ishii K
  • Journal Title: World Neurosurg Volume: 97 Pages: 757-757
  • DOI: 10.1016/j.wneu.2016.10.018
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Retrospective Cohort Study Comparing the Safety and Efficacy of Minimally Invasive Versus Open Surgical Techniques in the Treatment of Spinal Metastases (2016)
  • Author(s): Hikata T, Isogai N, Shiono Y, Funao H, Okada E, Fujita N, Iwanami A, Watanabe K, Tsuji T, Nakamura M, Matsumoto M, Ishii K
  • Journal Title: Clin Spine Surg Volume: 00 Issue: 8 Pages: 1-6
  • DOI: 10.1097/bsd.0000000000000460
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 脊椎脊髄手術における合併症 -出血・神経損傷・感染症の予防と対処法- (2017)
  • Author(s): 石井賢
  • Organizer: 第34回東京整形外科手術フォーラム
  • Invited
• [Presentation] 整形外科・脊椎領域における感染症治療 (2017)
  • Author(s): 石井賢
  • Organizer: 第30回日本臨床整形外科学会学術集会
  • Invited
• [Presentation] 脊椎脊髄治療における合併症－対策と治療の最前線－ (2017)
  • Author(s): 石井賢
  • Organizer: 横浜慢性疼痛研究会
  • Invited
• [Presentation] 共振周波数解析を用いた新しい非侵襲的椎弓根スクリュー設置強度評価法. (2016)
  • Author(s): 中島大輔, 名倉武雄, 河奈裕正, 陣崎雅弘, 松本守雄, 中村雅也, 石井賢
  • Organizer: 第25回日本インストゥルメンテーション学会
  • Place of Presentation: 長崎ブリックホール（長崎県長崎市）
  • Year and Date: 2016-10-28
• [Presentation] Minimally invasive spine stabilization with percutaneous sacropelvic fixation for spondylodiscitis in the lower lumbar spine (2016)
  • Author(s): Funao H, Kebaish K, Isogai N, Fujita N, Hikata T, Iwanami A, Watanabe K, Koyanagi T, Nakamura M, Matsumoto M, Ishii K
  • Organizer: Society for Minimally Invasive Spine Surgery 2016 Spine Week
  • Place of Presentation: シンガポール
  • Year and Date: 2016-06-05
  • Int'l Joint Research / Invited
• [Patent(Industrial Property Rights)] 血中バイオマーカー (2017)
  • Inventor(s): 石井賢、磯貝宜広
  • Industrial Property Rights Holder: 石井賢、磯貝宜広
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas