Elucidation of osteoporotic pain by a manifestation search of a bone resorption
| Project/Area Number |
15K10468
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
加藤 祥 三重大学, 医学系研究科, リサーチアソシエイト (30741152)
須藤 啓広 三重大学, 医学系研究科, 教授 (60196904)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨粗鬆症 / 疼痛 / 骨痛 / 酸感受性受容体 / ビスフォスフォネート |
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| Outline of Final Research Achievements |
Ovariectomy induced bone loss and mechanical hyperalgesia in hindlimbs with upregulation of TRPV1 and CGRP expressions in DRG neurons innervating hindlimbs. Alendronate or teriparatide prevented ovariectomy-induced bone loss and mechanical hyperalgesia in ovariectomized mouse hindlimbs, and it suppressed upregulation of pain markers (TRPV1 and CGRP expressions).
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Report
(4 results)
Research Products
(8 results)
