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Investigation of neuronal activity in the central nervous system and flight reaction induced by acute or chronic nociceptive stress

Research Project

Project/Area Number 15K10500
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

OHNISHI Hideo  産業医科大学, 医学部, 非常勤医師 (20279342)

Co-Investigator(Kenkyū-buntansha) 上田 陽一  産業医科大学, 医学部, 教授 (10232745)
Co-Investigator(Renkei-kenkyūsha) SAKAI Akinori  産業医科大学, 医学部, 教授 (90248576)
MORI Toshiharu  産業医科大学, 医学部, 非常勤医師 (80525444)
KAWASAKI Makoto  産業医科大学, 医学部, 講師 (40644860)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords視床下部 / 侵害刺激 / 脊髄 / ノックアウトマウス / Fos / FosB / TRPV1 / TRPV4 / 関節炎 / 切開 / カプサイシン / 4α-PDD / 逃避行動 / eye wipe / 腫脹 / ホルマリン
Outline of Final Research Achievements

We investigated Fos protein or FosB protein expression as markers of neuronal activity in the central nervous system after various nociceptive stimuli in wild type, TRPV1 knockout, TRPV4 knockout, and TRPV1V4 knockout mice. We also evaluated flight reaction against volatilized formalin in these mice. The results suggested that TRPV1 is involved in neuronal activity in the PVN after acute nociceptive stimuli. In the postoperative pain model, it is suggested that TRPV1 and TRPV4 are involved in neuronal activity in laminae III-IV of the dorsal spinal cord. There was no relevance between TRPV1/TRPV4 and FosB protein expression in laminae I-II of the dorsal spinal cord after chronic nociceptive stimuli caused by type II collagen antibody induced arthritis. Moreover, there was no difference among flight reaction of these mice against volatilized formalin.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (58 results)

All 2018 2017 2016 2015

All Journal Article (14 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 13 results,  Open Access: 8 results,  Acknowledgement Compliant: 5 results) Presentation (44 results) (of which Int'l Joint Research: 12 results)

  • [Journal Article] Activation of endogenous arginine vasopressin neurons inhibit food intake: by using a novel transgenic rat line with DREADDs system2017

    • Author(s)
      Yoshimura Mitsuhiro、Nishimura Kazuaki、Nishimura Haruki、Sonoda Satomi、Ueno Hiromichi、Motojima Yasuhito、Saito Reiko、Maruyama Takashi、Nonaka Yuki、Ueta Yoichi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 15728-15728

    • DOI

      10.1038/s41598-017-16049-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of dietary salt intake on epithelial Na+ channels (ENaC) in vasopressin magnocellular neurosecretory neurons in the rat supraoptic nucleus.2017

    • Author(s)
      Sharma K, Haque M, Guidry R, Ueta Y, Teruyama R.
    • Journal Title

      J Physiol.

      Volume: 595 Issue: 17 Pages: 5857-5874

    • DOI

      10.1113/jp274856

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of central nesfatin-1 neurons on oxytocin-induced feeding suppression in rats.2017

    • Author(s)
      Saito R, Sonoda S, Ueno H, Motojima Y, Yoshimura M, Maruyama T, Hashimoto H, Tanaka K, Yamamoto Y, Kusuhara K, Ueta Y
    • Journal Title

      Neurosci Lett.

      Volume: 655 Pages: 54-60

    • DOI

      10.1016/j.neulet.2017.06.049

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation of central nesfatin-1/NucB2 after intraperitoneally administered cisplatin in rats2017

    • Author(s)
      Akiyama Y, Yoshimura M, Nishimura K, Nishimura H, Sonoda S, Ueno H, Mitojima Y, Saito R, Maruyama T, Nonaka Y, Hashimoto H, Uezono Y, Hirata K, Ueta Y
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 490(3) Issue: 3 Pages: 794-799

    • DOI

      10.1016/j.bbrc.2017.06.119

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Possible contribution of pannexin-1 to capsaicin-induced ATP release in rat nasal columnar epithelial cells.2017

    • Author(s)
      Ohbuchi Toyoaki、Do Ba Hung、Koizumi Hiroki、Takeuchi Shoko、Ueta Yoichi、Suzuki Hideaki
    • Journal Title

      Channels

      Volume: 11 Issue: 4 Pages: 273-280

    • DOI

      10.1080/19336950.2017.1293209

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an imaging system for in vivo real-time monitoring of neuronal activity in deep brain of free-moving rats.2017

    • Author(s)
      Iijima N, Miyamoto S, Matsumoto K, Takumi K, Ueta Y, Ozawa H.
    • Journal Title

      Histochem Cell Biol.

      Volume: 148 Issue: 3 Pages: 289-298

    • DOI

      10.1007/s00418-017-1576-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of the induction of c- fos -eGFP and Fos protein in the rat spinal cord and hypothalamus resulting from subcutaneous capsaicin or formalin injection2017

    • Author(s)
      Motojima Yasuhito、Matsuura Takanori、Yoshimura Mitsuhiro、Hashimoto Hirofumi、Saito Reiko、Ueno Hiromichi、Maruyama Takashi、Sonoda Satomi、Suzuki Hitoshi、Kawasaki Makoto、Ohnishi Hideo、Sakai Akinori、Ueta Yoichi
    • Journal Title

      Neuroscience

      Volume: 356 Pages: 64-77

    • DOI

      10.1016/j.neuroscience.2017.05.015

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Orexin action on oxytocin neurons in the paraventricular nucleus of the hypothalamus.2017

    • Author(s)
      Maejima Y, Takahashi S, Takasu K, Takenoshita S, Ueta Y, Shimomura K.
    • Journal Title

      Neuroreport

      Volume: 28 Issue: 6 Pages: 360366-360366

    • DOI

      10.1097/wnr.0000000000000773

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] トランスジェニックラットを用いた視床下部オキシトシンニューロンを介した摂食調節機序の可視化2017

    • Author(s)
      元嶋 尉士、上田 陽一
    • Journal Title

      自律神経

      Volume: 54 Pages: 209-212

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Effects of central administration of oxytocin-saporin cytotoxin on chronic inflammation and feeding/drinking behaviors in adjuvant arthritic rats.2016

    • Author(s)
      Matsuura T, Kawasaki M, Hashimoto H, Yoshimura M, Motojima Y, Saito R, Ueno H, Maruyama T, Sabanai K, Mori T, Ohnishi H, Sakai A, Ueta Y
    • Journal Title

      Neuroscience Letters

      Volume: 621 Pages: 104-110

    • DOI

      10.1016/j.neulet.2016.04.010

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Possible involvement of the rat hypothalamo-neurohypophysial/-spinal oxytocinergic pathways in acute nociceptive responses2016

    • Author(s)
      Matsuura, T. Kawasaki, M . Hashimoto, H. Yoshimura, M. Motojima, Y. Saito, R. Ueno,H. Maruyama, T. Ishikura, T. Sabanai, K, Mori, T. Ohnishi, H.Onaka, T. Sakai, A. Ueta, Y.
    • Journal Title

      Journal of Neuroendcrinology

      Volume: 28 Issue: 6

    • DOI

      10.1111/jne.12396

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effects of peripherally administered cholecystokinin-8 and secretin on feeding/drinking and oxytocin-mRFP1 fluorescence in transgenic rats.2016

    • Author(s)
      Motojima Y, Kawasaki M, Matsuura T, Saito R, Yoshimura M, Hashimoto H, Ueno H, Maruyama T, Suzuki H, Ohnishi H, Sakai A, Ueta Y
    • Journal Title

      Neuroscience Research

      Volume: 印刷中 Pages: 63-69

    • DOI

      10.1016/j.neures.2016.02.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fluorescent visualisation of oxytocin in the hypothalamo-neurohypophysial/-spinal pathways after chronic inflammation in oxytocin-monmeric red fluorescent protein 1 transgenic rats.2015

    • Author(s)
      Matsuura, T. Kawasaki, M . Hashimoto, H. Ishikura, T. Yoshimura, M. Ohkubo, JI. Maruyama, T. Motojima, Y. Sabanai, K. Mori, T. Ohnishi, H. Sakai, A. & Ueta, Y.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 27(7) Issue: 7 Pages: 636-646

    • DOI

      10.1111/jne.12290

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of TRPV1 and TRPV4 in nociceptive stimulation-induced nocifensive behavior and neuroendocrine response in mice.2015

    • Author(s)
      Ishikura, T. Suzuki, H. Shoguchi, K. Koreeda, Y. Aritomi, T. Matsuura, T. Yoshimura, M. Ohkubo, JI. Maruyama, T. Kawasaki, M. Ohnishi, H. Sakai, A. Mizuki, M. & Ueta, Y.
    • Journal Title

      Brain Rsearch Bulletin

      Volume: 118 Pages: 7-16

    • DOI

      10.1016/j.brainresbull.2015.08.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] トランスジェニックラットを用いた急性腎障害ストレスが中枢神経へ与える影響の可視化2018

    • Author(s)
      上野啓通、田中健太郎、西村春来、西村和朗、園田里美、元嶋尉士、齋藤玲子、吉村充弘、丸山崇、芹野良太、田村雅仁、尾辻豊、上田陽一
    • Organizer
      第47回日本心脈管作動物質学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 加齢トランスジェニックラットの視床下部-下垂体後葉系におけるウロコルチン様免疫反応を伴うオキシトシン-単量体赤色蛍光蛋白1蛍光強度の増加2018

    • Author(s)
      大野重雄、丸山崇、橋本弘史、藤原広明、藤木通弘、吉村充弘、元嶋尉士、齋藤玲子、上野啓通、園田里美、大野素子、梅津祐一、浜村明徳、佐伯覚、上田陽一
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレプトゾトシン投与ラットにおける視床下部摂食促進・制御ペプチド発現の絶食による影響2018

    • Author(s)
      園田里美、西村和朗、西村春来、田中健太郎、上野啓通、元嶋尉士、齋藤玲子、吉村充弘、丸山崇、岡田洋右、田中良哉、上田陽一
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] シスプラシン末梢投与によりラット視床下部オキシトシンニューロンが活性化する2018

    • Author(s)
      橋本弘史、荒瀬光一、元嶋尉士、齋藤玲子、園田里美、上野啓通、吉村充弘、丸山崇、平田敬治、瀬尾芳輝、上田陽一
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] バゾプレッシン-eGFPトランスジェニックラットにおける両側腎臓摘出後の視床下部バゾプレッシンの合成亢進2018

    • Author(s)
      上野啓通、吉村充弘、丸山崇、上田陽一
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regional and time-course differences in the induction of c-fos-eGFP fluorescence in the spinal cord and hypothalamus of transgenic rats after nociceptive and inflammatory stimuli2017

    • Author(s)
      Motojima,Y. Kawasaki,M.Suzuki,H. Ohnishi,H. Matsuura,T. Yoshimura,M.Hashimoto, H.Saito,R. Ueno, H.Maruyama,T. Sonoda,S. Mori,T. Sabanai,K. Sakai,A. Ueta,Y.(
    • Organizer
      American Academy of Orthopaedic Surgeons
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Transgenic approaches to regulate the neuronal activity in rat vasopressin neuron2017

    • Author(s)
      Mitsuhiro Yoshimura,Takashi maruyama and Yoichi Ueta.
    • Organizer
      IBNS 2017 Annual Meeting in Hiroshima,Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] For expression in the hypothalamus and brainstem after tail suspension in rats2017

    • Author(s)
      Takashi Maruyama,Yasuhito Motojima,Mitsuhiro Yoshimura,HirofumiHashimoto,Satomi Sonoda,Hiromichi Ueno,Reiko Saito,Yoichi Ueta
    • Organizer
      IBNS 2017 Annual Meeting in Hiroshima,Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nesfatin -1/NucB2 Neurons in the Hypothalamus and Brainstem Activated by Intraperitoneally Administered Cisplatin in Rats2017

    • Author(s)
      Yoichi Ueta,Mitsuhiro Yoshimura, Maruyama,Satomi Sonoda,Hiromichi Ueno,Yasuhito Monojima,Reiko Saito,Takashi Maruyama,Hiroshi Hasimoto;Yasuhito Uezono
    • Organizer
      IBNS 2017 Annual Meeting in Hiroshima,Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of vestibular lesion on hypothalamic feeding-regulating neuropeptides after being Exposed to hyper gravity in mice2017

    • Author(s)
      Satomi Sonoda,Mitsuhiro Yoshimura,Hiromichi Ueno,Yasuhito Motojima,Reiko Saito, Takashi Maruyama,Hirofumi Hashimoto,Hironobu Morita,Yoichi Ueta
    • Organizer
      IBNS 2017 Annual Meeting in Hiroshima,Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transgenic approaches to regulate the neuronal activity in rat vasopressin neuron by using Optogenetics and DREADDs technology2017

    • Author(s)
      Mitsuhiro Yoshimura, Yoichi Ueta
    • Organizer
      12th World Congress on Neurohypophysial Hormones
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Arginine vasopressin-enhanced green fluorescent protein synthesis in the hypothalamus after peripheral administration of furosemide in the transgenic rat2017

    • Author(s)
      Hiromichi Ueno, Satomi Sonoda, Yasuhito Motojima, Reiko Saito, Mitsuhiro Yoshimura, Takashi Maruyam, Ryota Serino, Masahito Tamura, Yutaka Otsuji, Yoichi Ueta
    • Organizer
      12th World Congress on Neurohypophysial Hormones
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased oxytocin-mRFP1 fluorescent intensity with urocotin-like immunoreactivity in the hypothalamo-neurohypophysial system of aged transgenic rats2017

    • Author(s)
      Shigeo Ohno,Hirofumi Hashimoto,Hiroaki Fujihara,Nobuhiro Fujiki, Mitsuhiro Yoshimura,Takashi Maruyama,Yasuhito Motojima,Reiko Saito, Hiromichi Ueno,Satomi Sonoda,Motoko Ohno,Yuichi Umezu,Akinori Hamamura,Satoru Saeki and Yoichi Ueta
    • Organizer
      Fourth World Congress of Reproductive Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fluorescent visualization of oxytocin neurons activated by acute nociceptive stimuli in the c-fos-eGFP transgenic rats2017

    • Author(s)
      Yasuhito Motojima,Haruki Nishimura,Takanori Matsuura,Mitsuhiro Yoshimura,Hirofumi Hashimoto,Reiko Saito,Hiromichi Ueno,Takashi Maruyama,Satomi Sonoda,Kazuaki Nishimura,Kentaro Tanaka,Hitoshi Suzuki,Makoto Kawasaki,Hideo Ohnishi,Akinori sakai and Yoichi Ueta
    • Organizer
      Fourth World Congress of Reproductive Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 下垂体後葉ホルモンによる疼痛・炎症制御機能2017

    • Author(s)
      上田陽一
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] グレリンのラット脳室内投与による摂食促進作用に対するオレキシン受容体ア タゴニストの抑制効果についての検討2017

    • Author(s)
      宗まりこ、橋本弘史、齋藤玲子、山本幸代、吉村充弘、丸山崇、楠原浩一、上田陽一
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット視床下部・延髄のnesfatin-1含有ニューロンへのOxytocin,Oxytocin analogの末梢投与およびKisspeptinの中枢内投与による活性化2017

    • Author(s)
      齋藤玲子、園田里美、上野啓通、元嶋尉士、吉村充弘、丸山崇、橋本弘史、山本幸代、楠原浩一、上田陽一
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Acrivation of brain nesfatin-1/NucB2 neuron after intraperitoneally administered cisplatin in rats2017

    • Author(s)
      吉村充弘、園田里美、上野啓通、齋藤玲子、元嶋尉士、丸山崇、橋本弘史、上田 陽一
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス・ラットの視床下部摂食促進性および制御制性神経ペプチドの変動:重力変化の影響2017

    • Author(s)
      園田里美、吉村充弘、上野啓通、元嶋尉士、齋藤玲子、丸山崇、橋本弘史、森田啓之、岡田洋右、田中良哉、上田陽一
    • Organizer
      第90回日本内分泌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ストレプトゾトシン誘発糖尿病モデルラット脳室内へのフロリジン投与後のFos タンパク発現の検討2017

    • Author(s)
      園田里美、西村和朗、西村春来、田中健太郎、上野啓通、元嶋尉士、齋藤玲子、 吉村充弘、丸山崇、上田陽一
    • Organizer
      第16回九州脳・高血圧・循環制御研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 炎症・疼痛刺激に対するラット脊髄・視床下部のc-fos-eGFPおよびFosタンパクの発現動態の検討2017

    • Author(s)
      元嶋 尉士、川崎 展、大西 英生、鈴木 仁士、松浦 孝紀、森 俊陽、佐羽内 研、塚本 学、上田 陽一
    • Organizer
      第61回日本リウマチ学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] トランスジェニックラットを用いた急性腎障害モデルの視床下部におけるバゾプレッシンの動態に関する検討2017

    • Author(s)
      上野 啓通、吉村 充弘、丸山 崇、上田 陽一
    • Organizer
      第27回日本病態生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of traditional kampo medicine,kamikihito on acute/chronic nociceptive stress in rats.2017

    • Author(s)
      丸山崇、吉村充弘、元嶋尉士、園田里美、上野啓通、齋藤玲子、上田陽一
    • Organizer
      国際自律神経学会2017 ISAN (International Society of Autonomic Neuroscience)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Activation of autonomic nervous system and arginine vasopressin (AVP) synthesis in the central nerve system after peripheral administration of furosemide in AVP-eGFP transgenic rat.2017

    • Author(s)
      H Ueno, H Nishimura, K Nishimura, S Sonoda, Y Motojima, R Saito, M Yoshimura, T Maruyama, R Serino, M Tamura, Y Otsuji, Y Ueta
    • Organizer
      第70回日本自律神経学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] トランスジェニックラットを用いた急性腎不全モデルにおける中枢でのバソプレッシン合成および自律神経への影響の検討2017

    • Author(s)
      H Ueno, H Nishimura, K Nishimura, S Sonoda, Y Motojima, R Saito, M Yoshimura, T Maruyama, M Tamura, Y Otsuji, Y Ueta
    • Organizer
      第70回日本自律神経学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel transgenic rat lines regulating the neuronal activity in rat vasopressin neuron by using Optogenetics and DREDDs technology.2017

    • Author(s)
      吉村 充弘、丸山 崇、上田 陽一
    • Organizer
      第70回日本自律神経学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] シスプラチン末梢投与によりラット視床下部オキシトシン分泌ニューロンが活性化する2017

    • Author(s)
      荒瀬 光一、橋本 弘史、平田 敬治、上園 保仁、上田 陽一
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 絶食・拒食・悪液質モデル動物における視床下部摂食関連ペプチドと甲状腺ホルモンの動態2017

    • Author(s)
      上田 陽一
    • Organizer
      第60回日本甲状腺学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 加齢遺伝子改変ラットの視床下部-下垂体系におけるウロコルチン増加を伴うオキシトン蛍光蛋白の増加2017

    • Author(s)
      大野 重雄、丸山 崇、橋本 弘史、藤原 広明、藤木 通弘、吉村 充弘、元嶋 尉士 齋藤 玲子、上野 啓通、園田 里美、大野 素子、梅津 祐一、浜村 明徳、佐伯 覚、上田 陽一
    • Organizer
      第68回西日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Activation of central nesfatin-1/NucB2 after intraperitoneally administered cisplatin in rats2017

    • Author(s)
      秋山 泰樹、吉村 充弘
    • Organizer
      第35回産業医科大学学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 薬理遺伝学的手法を用いたラットバゾプレッシンニューロン活動制御2017

    • Author(s)
      吉村 充弘、丸山 崇、上田 陽一
    • Organizer
      第44回日本神経内分泌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット尾懸垂時の延髄および視床下部における Fos タンパクの発現動態2016

    • Author(s)
      元嶋 尉士、上野 啓通、吉村 充弘、丸山 崇、橋本 弘史、齋藤 玲子、園田 里美、川崎 展、鈴木 仁士、大西 英生、酒井 昭典、上田 陽一
    • Organizer
      第67回西日本生理学会
    • Place of Presentation
      レインボー桜島(鹿児島県鹿児島市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Regional and time-course differences in the induction of c-fos-eGFP fluorescene in the spinal cord and hypothalamus of transgenic rats after subcutaneous injections of capsaicin and formalin.2016

    • Author(s)
      Motojima.Y, Suzuki H,Matsuura T, Yoshimura M, Hashimoto H, Saito R, Ueno H, Maruyama T, Sonoda S, Kawasaki M, Ohnishi H, Sakai A, Ueta Y.
    • Organizer
      The 13th Japan-Korea Joint Symposium on Brain Science and Cardiac and Smooth Muscles.
    • Place of Presentation
      佐賀大学(佐賀県佐賀市)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 4日侵害刺激による脊髄および視床下部におけるFosタンパクの発現動態のc-fos-eGFPトランスジェニックラットを用いた検討2016

    • Author(s)
      元嶋 尉士、鈴木 仁士、松浦 孝紀、吉村 充弘、橋本 弘史、齋藤 玲子、上野 啓道、丸山 崇、園田 里美、川崎 展、大西 英生、酒井 昭典、上田 陽一
    • Organizer
      第34回内分泌代謝学 サマーセミナー
    • Place of Presentation
      ホテル夢家(福岡県糟屋郡)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Plasma osmolality/fluid volume sensing and drinking behavior via TRPV1 and 4 channels in mice.2016

    • Author(s)
      Ueta Y, Matsuura T, Motojima Y, Ueno H, Yoshimura M, Maruyama T, Hashimoto H, Ohnishi H.
    • Organizer
      17th International Symposium on Olfaction and Taste.
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-06-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 炎症・疼痛ストレスに対する脊髄および視床下部におけるFosタンパクの発現動態のc-fos-eGFPトランスジェニックラットを用いた検討2016

    • Author(s)
      元嶋 尉士、松浦 孝紀、鈴木 仁士、川崎 展、大西 英生、森 俊陽、佐羽内 研、塚本 学、上田 陽一
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 侵害刺激による脊髄および視床下部におけるFosタンパクの発現動態のc-fos-eGFPトランスジェニックラットを用いた検討2016

    • Author(s)
      元嶋 尉士、松浦 孝紀、鈴木 仁士、齋藤 玲子、吉村 充弘、橋本 弘史、上野 啓通、丸山 崇、川崎 展、大西 英生、酒井 昭典、上田 陽一
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Possible involvement of the rat hypothalamo-neurohypophysial /spinal oxytocinergic pathways in acute nociceptive responses2016

    • Author(s)
      Matsuura, T. Motojima, Y. Yoshimura, M. Saito, R. Ueno, H. Maruyama, T. Hashimoto, H. Kawasaki, M. Ishikura, T. Ohnishi, H. Onaka, T. Sakai, A. & Ueta, Y.
    • Organizer
      Interdisciplinary of Medical, Dental and Soft-material Researches on the move -Showcase Review in Kitakyushu-
    • Place of Presentation
      西日本国際会議場(北九州市)
    • Year and Date
      2016-01-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] TRPV1およびTRPV4ノックアウトマウスにおける浸透圧・非浸透圧刺激後の飲水行動の検討2016

    • Author(s)
      松浦 孝紀、元嶋 尉士、齋藤 玲子、上野 啓通、吉村 充弘、橋本 弘史、鈴木 仁士、川崎 展、大西 英生、酒井 昭典、上田 陽一
    • Organizer
      第26回バゾプレッシン研究会
    • Place of Presentation
      慶応義塾大学病院2号館11階大会議室(東京)
    • Year and Date
      2016-01-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Possible involvements of TRPV1 and TRPV4 in neuroendocrine response and drinking behavior2015

    • Author(s)
      Ueta, Y. Matsuura, T. MOtojima, Y. Yoshimura, M. Shoguchi, K. Maruyama, T. Hashimoto, H. Ishikura, T. Kawasaki, M. Ohnishi, H. & Sakai, A.
    • Organizer
      The 13th International Symposium on Molecular and Neural Machanisms of Taste and Olfactory Perception
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2015-11-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] アジュバンド関節炎モデルラットにおける下垂体後葉系および視床下部-脊髄系のオキシトシンの役割2015

    • Author(s)
      松浦 孝紀、元嶋 尉士、上野 啓通、齋藤 玲子、吉村 充弘、橋本 弘史、鈴木 仁士、川崎 展、大西 英生、酒井 昭典、上田 陽一
    • Organizer
      第66回西日本生理学会
    • Place of Presentation
      久留米大学筑水会館(久留米)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
  • [Presentation] TRPV1およびTRPV4ノックアウトマウスにおける浸透圧・非浸透圧刺激後の飲水行動の検討2015

    • Author(s)
      元嶋 尉士、松浦 孝紀、齋藤 玲子、上野 啓通、吉村 充弘、橋本 弘史、鈴木 仁士、川崎 展、大西 英生、酒井 昭典、上田 陽一
    • Organizer
      第25回日本病態生理学会
    • Place of Presentation
      愛媛大学城北キャンパス(松山)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of osmotic and non-osmotic stimuli on drinking behavior in TRPV1 and TRPV4 knockout mice2015

    • Author(s)
      Ueta, Y. Matsuura, T. Motojima, Y. Yoshimura, M. Shoguchi, K. Maruyama, T. Hashimoto, H. Kawasaki, M. Ohnishi, H. & Sakai, A.
    • Organizer
      International Behavioral Neuroscience Society
    • Place of Presentation
      Victoria, Canada
    • Year and Date
      2015-06-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 急性炎症・疼痛モデルラットでの視床下部および脊髄におけるオキシトシン-単量体赤色蛍光タンパク1融合遺伝子の発現動態ならびにその役割について2015

    • Author(s)
      松浦 孝紀、川崎 展、元嶋 尉士、鈴木 仁士、大西 英生、上田 陽一
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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