The global analyses of memory and learning after the exposure of inahalational anesthetics

• Project/Area Number: 15K10517
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Yokohama City University
• Principal Investigator: INAGAWA Gaku 横浜市立大学, 医学研究科, 客員准教授 (60336584)
• Co-Investigator(Kenkyū-buntansha): 後藤 隆久 横浜市立大学, 医学研究科, 教授 (00256075) ; 内本 一宏 横浜市立大学, 附属市民総合医療センター, 助教 (50710951) ; 宮崎 智之 横浜市立大学, 医学部, 准教授 (30580724) ; 水原 敬洋 横浜市立大学, 附属病院, 講師 (00637712)
• Research Collaborator: ASAKURA Ayako
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 麻酔科学 / 神経科学 / 術後神経認知機能障害

Outline of Final Research Achievements

Young adult Sprague-Dawley rats were exposed to desflurane (0.7 or 1.2 MAC) for 2 h. The contextual learning was significantly impaired on day 1 of exposure in 1.2 MAC desflurane group compared with the control group, but not in 0.7 MAC group. Learning was not impaired on days 3 and 7. The hippocampal LTP and the GluR1 expression after IA training on day 1 were significantly suppressed in the desflurane group compared with the control group.
We therefore concluded that exposure of relatively high concentration of desflurane cause reversible impairment of learning and memory on day 1 of exposure in young adult rats due to inhibition of AMPA trafficking.

Research Products

• [Presentation] Effects of desflurane exposure on hippocampal learning (2017)
  • Author(s): Asakura A, Uchimoto K, Inagawa G, Goto T
  • Organizer: Euroanaesthesia 2017
  • Int'l Joint Research
• [Presentation] デスフルラン曝露が海馬記憶学習に与える影響 (2017)
  • Author(s): 朝倉彩子，内本一宏，伊奈川岳，後藤隆久
  • Organizer: 日本麻酔科学会第６４回学術集会
• [Presentation] デスフルラン曝露が海馬記憶学習に与える影響 (2015)
  • Author(s): 朝倉彩子、内本一宏、伊奈川岳、後藤隆久
  • Organizer: 日本麻酔科学会第６２回学術集会
  • Place of Presentation: 神戸ポートピアホテル、神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-05-28