Superior efficacy of lipid emulsion infusion over serum alkalinization in reversing amitriptyline-induced cardiotoxicity in guinea pig
| Project/Area Number |
15K10519
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 三環系抗うつ薬中毒 / 脂肪乳剤 / 心筋Naチャネル / パッチクランプ / ランゲンドルフ / 三環系抗うつ薬 / ランゲンドルフ灌流実験 |
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| Outline of Final Research Achievements |
In the present study, we investigated the effectiveness of lipid emulsion in reversing amitriptyline-induced cardiotoxicity compared to that of NaHCO3 administration in the guinea pig in- vivo and in isolated hearts. We also recorded voltage-gated Na+ channel currents (INa) of left ventricular cardiomyocytes using the whole-cell patch clamp technique to evaluate the effects of lipid emulsion on amitriptyline induced inhibition of Na+ channels compared to those of alkalinization. Our results of in vivo and vitro studies demonstrate that lipid emulsion has greater recovery effects on amitriptyline induced cardiotoxicity compared to alkalinization therapy.
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Report
(4 results)
Research Products
(7 results)
