• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research of a leukocyte and platelet dysfunction causing by cardiopulmonary bypass

Research Project

Project/Area Number 15K10547
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionTokyo Medical University

Principal Investigator

Itabashi Toshio  東京医科大学, 医学部, 助教 (00439738)

Co-Investigator(Kenkyū-buntansha) 内野 博之  東京医科大学, 医学部, 主任教授 (60266476)
Research Collaborator Elmer Eskil  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords血小板 / ミトコンドリア / 人工心肺 / 呼吸能 / ミトコンドリア呼吸能 / 心臓血管手術 / j人工心肺 / 白血球
Outline of Final Research Achievements

A platelet and leukocyte dysfunction occur in a cardiopulmonary bypass and hypothermia by a cardiovascular surgery. In this study, we measure a mitochondrial respiratory function of a platelet.
As a result, a decline of a function in a Complex Ⅰ, Complex Ⅲ, and Complex Ⅳ which were platelet mitochondria breathing chain was found in the cardiopulmonary bypass.
We confirmed that the function of the platelet mitochondria breathing chain complex was decline with a cardiopulmonary bypass time was long but got back after an operation.

Academic Significance and Societal Importance of the Research Achievements

心臓血管外科手術において、人工心肺による血小板機能障害による出血助長の可能性が想定されているが、その機序は明らかでない。本研究では、人工心肺中の血小板ミトコンドリア呼吸能を測定した。結果として、ミトコンドリア呼吸鎖複合体の機能低下が確認され、ATP産生低下を引き起こし止血能低下に関与する可能性が示唆された。ミトコンドリア呼吸鎖複合体は、各complexは連動して機能するため、どのcomplexが大きく影響しているかは今後も引き続き研究が必要であるが、障害部位が特定され、機能を補う薬剤が発見されれば、人工心肺後の出血を抑えられる可能性がある。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results)

  • [Presentation] 人工心肺下成人心臓手術が血小板ミトコンドリア呼吸能に与える影響の検討2017

    • Author(s)
      魚島直美
    • Organizer
      日本心臓血管麻酔学会第22回学術大会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi