| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The patterns of myeloid-derived suppressor cells (MDSC) in peripheral blood of patients with metastatic renal cell carcinoma (mRCC) were studied and useful prognostic factors were examined. Myeloid cell antigens on peripheral blood neutrophilic cells and monocytic cells in mRCC patients were measured by flow cytometry. A comprehensive RNA expression in polymorphonuclear leukocytes (PMN) was also analyzed. As a result, the MFI (average fluorescence intensity) or CV (coefficient variation) of CD16, GPI-80, and LAP-1 on neutrophilic cells or monocytic cells were increased. It was indicate that the diversity of the myeloid cell population is increased. In addition, mRNA expression of PMNs was different between healthy volunteers and mRCC patients. MFI of GPI-80 on monocytic cells was associated with the clinical outcome and considered to be a useful prognostic marker of mRCC.
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