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Interstitial cystitis and possible urine biomarkers

Research Project

Project/Area Number 15K10619
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionThe University of Tokyo

Principal Investigator

Niimi Aya  東京大学, 医学部附属病院, 登録診療員 (00376451)

Co-Investigator(Kenkyū-buntansha) 野宮 明  東京大学, 医学部附属病院, 助教 (30372379)
藤田 泰典  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30515888)
井川 靖彦  東京大学, 医学部附属病院, 特任教授 (40159588)
本間 之夫  東京大学, 医学部附属病院, 登録診療員 (40165626)
伊藤 雅史  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (80393114)
相澤 直樹  東京大学, 医学部附属病院, 特任講師 (80595257)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords間質性膀胱炎 / miRNA
Outline of Final Research Achievements

Interstitial cystitis are refractory disease with unknown etiology. There is no radical treatment so far. The aim of our study is to investigate microRNA, chemokines and cytokines elevated in the bladder tissue of Hunner type interstitial cystitis (HIC) as urinary markers for distinguishing HIC from non Hunner type interstitial cystitis (NHIC).In the first and second year, microarray analysis of miRNA was performed and found miR200 families were elevated in NHIC, compared to HIC and the control groups. It was validated by real-time PCR. Additionally, in situ hybridization of miR200 family was performed. It showed miR-200b was localized in urothelium of NHIC whereas no miR-200b was detected in HIC. Through these analysis, we found that genes related to chemokine are elevated in both HIC. In third year, ELISA was performed to evaluate feasibility of those markers found in the second year. The CXCL10 and NGF was elevated in HIC and CXCL10 can be used as arpossible biomarker

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results)

  • [Journal Article] Digital quantitative analysis of mast cell infiltration in interstitial cystitis.2018

    • Author(s)
      Akiyama Y, Maeda D, Morikawa T, Niimi A, Nomiya A, Yamada Y, Igawa Y, Goto A, Fukayama M, Homma Y.
    • Journal Title

      Neurourol Urodyn.

      Volume: 37 Issue: 2 Pages: 650-657

    • DOI

      10.1002/nau.23365

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extent of Hunner lesions: The relationships with symptom severity and clinical parameters in Hunner type interstitial cystitis patients2018

    • Author(s)
      Akiyama Yoshiyuki、Niimi Aya、Nomiya Akira、Yamada Yukio、Nakagawa Tohru、Fujimura Tetsuya、Fukuhara Hiroshi、Kume Haruki、Igawa Yasuhiko、Homma Yukio
    • Journal Title

      Neurourology and Urodynamics

      Volume: 37 Issue: 4 Pages: 1441

    • DOI

      10.1002/nau.23467

    • URL

      https://pure.teikyo.jp/en/publications/7662b3a1-f0d2-4623-994b-1b05e28030bf

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis2017

    • Author(s)
      Niimi Aya、Igawa Yasuhiko、Aizawa Naoki、Honma Toshiki、Nomiya Akira、Akiyama Yoshiyuki、Kamei Jun、Fujimura Tetsuya、Fukuhara Hiroshi、Homma Yukio
    • Journal Title

      Neurourol Urodyn

      Volume: 37(3) Issue: 3 Pages: 1113-1119

    • DOI

      10.1002/nau.23431

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Direct influence of systemic desensitization by resiniferatoxin on the activities of Aδ- and C-fibers in the rat primary bladder mechanosensitive afferent nerves.2016

    • Author(s)
      Aizawa N, Fukuhara H, Fujimura T, Homma Y, Igawa Y.
    • Journal Title

      Int J Urol

      Volume: 23 Issue: 11 Pages: 952-956

    • DOI

      10.1111/iju.13181

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sleep apnea and circadian extracellular fluid change as an independent factor for nocturnal polyuria2016

    • Author(s)
      Aya Niimi, Motofumi Suzuki, Yasuhiro Yamaguchi, Masaki Ishii, Tetsuya Fujimura, Tohru Nakagawa, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Masahiro Akishita, Yukio Homma
    • Journal Title

      Journal of Urology

      Volume: e-pub Issue: 4 Pages: 1183-1189

    • DOI

      10.1016/j.juro.2016.04.060

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased CXCR3 expression of infiltrating plasma cells in Hunner type interstitial cystitis.2016

    • Author(s)
      Akiyama Y, Morikawa T, Maeda D, Shintani Y, Niimi A, Nomiya A, Nakayama A, Igawa Y, Fukayama M, Homma Y
    • Journal Title

      Scientific Report

      Volume: 6 Issue: 1 Pages: 28652-28652

    • DOI

      10.1038/srep28652

    • NAID

      120007089053

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 20152016

    • Author(s)
      Homma Y, Ueda T, Tomoe H, Lin AT, Kuo HC, Lee MH, Oh SJ, Kim JC, Lee KS.
    • Journal Title

      Int J Urol

      Volume: 23 Issue: 7 Pages: 542-549

    • DOI

      10.1111/iju.13118

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hydrodistension with or without fulguration of hunner lesions for interstitial cystitis: Long-term outcomes and prognostic predictors.2015

    • Author(s)
      Niimi A, Nomiya A, Yamada Y, Suzuki M, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y.
    • Journal Title

      Neurourology and Urodynamics

      Volume: e-pub Issue: 8 Pages: 965-9

    • DOI

      10.1002/nau.22837

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 間質性膀胱炎の膀胱鏡および病理所見2017

    • Author(s)
      新美文彩
    • Organizer
      第24回日本排尿機能学会 教育セミナー(日本排尿機能学会認定医申請教育講演)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] INCREASE IN SPINAL FLUID LEVEL OF NEUROGENIC PAIN-RELATED LYSOPHOSPHATIDYLCHOLINES IN HUNNER TYPE INTERSTITIAL CYSTITIS2017

    • Author(s)
      Niimi A
    • Organizer
      International Continence Society Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シンポジウム「はじめてのFemale Urology」間質性膀胱炎2016

    • Author(s)
      新美 文彩
    • Organizer
      第81回 日本泌尿器科学会東部総会
    • Place of Presentation
      秋田、日本
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 教育セミナー(日本排尿機能学会認定医申請教育講演)「Female LUTS update」間質性膀胱炎2016

    • Author(s)
      新美 文彩
    • Organizer
      第23回 日本排尿機能学会
    • Place of Presentation
      東京、日本
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] シンポジウム「難治性過活動膀胱/間質性膀胱炎に対する治療」「間質性膀胱炎に対する膀胱水圧拡張術及びボツリヌストキシン注入療法」2015

    • Author(s)
      新美 文彩
    • Organizer
      第80回日本泌尿器科学会東部総会
    • Place of Presentation
      東京都、新宿区
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 過活動膀胱とその類似疾患―尿意切迫か尿意亢進か2015

    • Author(s)
      新美 文彩
    • Organizer
      第22回日本排尿機能学会
    • Place of Presentation
      北海道、札幌市
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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