Development of non-invasive bioimaging techniques for evaluation of transplantation related kidney injury.

• Project/Area Number: 15K10640
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Osaka University
• Principal Investigator: Shiro Takahara 大阪大学, 医学系研究科, 寄附講座教授 (70179547)
• Co-Investigator(Kenkyū-buntansha): 猪阪 善隆 大阪大学, 医学系研究科, 教授 (00379166) ; 黒田 輝 東海大学, 情報理工学部, 教授 (70205243) ; 市丸 直嗣 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 (70346211) ; 貝森 淳哉 大阪大学, 医学系研究科, 寄附講座准教授 (70527697)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 糖尿病性腎症 / 腎繊維化 / DTI / MRI / DTI MRI / 腎臓繊維化 / 腎移植

Outline of Final Research Achievements

Diabetic kidney disease (DKD) is the most important and frequent cause for end stage renal disease in Japan. Progression of chronic kidney disease (CKD) is reported to be closely related with renal fibrosis, whose detailed evaluation is now only possible by conventional and invasive kidney biopsy. So non-invasive bioimaging techniques for evaluation of kidney fibrosis has been sought in the real medical sites. The research group developed diffusion tensor imaging MRI (DTI MRI) using spin echo sequence, which enables us to analyze diffusion of water molecule in the multiple directions. It was discovered that DTI MRI could evaluate and visualized kidney fibrosis in rat DKD models.
In the future, it may be possible to evaluate kidney fibrosis non-invasively by applying this bioimaging technique.

Research Products

• [Journal Article] Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence (2017)
  • Author(s): Kaimori JY, Isaka Y, Hatanaka M, Yamamoto S, Ichimaru N, Fujikawa A, Shibata H, Fujimori A, Miyoshi S, Yokawa T, Kuroda K, Moriyama T, Rakugi H, Takahara S
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 5731-5731
  • DOI: 10.1038/s41598-017-06111-4
• [Journal Article] Diffusion Tensor Imaging MRI with spin echo sequence and long duration measurement was identified for evaluation of renal fibrosis in rat fibrosis model (2017)
  • Author(s): Jun-Ya Kaimori, Yoshitaka Isaka, Masaki Hatanaka, Satoko Yamamoto, Naotsugu Ichimaru, Akihiko Fujikawa, Hiroshi Shibata, Akira Fujimori, Sosuke Miyoshi, Takashi Yokawa, Kagayaki Kuroda, Toshiki Moriyama, Hiromi Rakugi, Shiro Takahara
  • Journal Title: Transplantation Proceedings Volume: 49 Issue: 1 Pages: 145-152
  • DOI: 10.1016/j.transproceed.2016.10.014
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 糖尿病性腎症の存在下でも可能な、DTI MRIによる腎線維化撮影法の確立 (2017)
  • Author(s): 貝森淳哉，猪阪善隆，余川隆, 市丸直嗣，高原史郎
  • Organizer: 第43回日本移植学会学術総会