Relationship between aurora and cohesin proteins in human oocytes with maternal age-relating chromosome abnormality
| Project/Area Number |
15K10656
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Atsushi セントマザー産婦人科医院, 院長 (70590313)
FUKUI Atsushi 兵庫医科大学, 医学部, 講師 (00321969)
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| Research Collaborator |
TAKEMOTO Yoichi セントマザー産婦人科医院, 胚培養士
NAKAMURA Rika 弘前大学, 医学部附属病院, 胚培養士
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 卵子老化 / 老化卵子 / 染色体異常 / 卵子の老化 / oocyte / aurora / chromosome cohesion |
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| Outline of Final Research Achievements |
The successful birth rate in human is known to be very low (about 23%) and decreases with maternal age. This phenomenon called as "oocyte aging" is accompanied by chromosome abnormality in general. We have been studying mechanism of the oocyte aging using low quality oocytes obtained from infertile women. In this study, we found that aurora and cohesin proteins, which control oocyte maturation and development, are responsible for oocyte aging. When the proteins were increased in human oocytes by treatment with a chemical treatment, chromosome aberrations were decreased, resulting in improving oocyte development.
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Report
(4 results)
Research Products
(18 results)
