Significance of serum anti-Mullerian hormone and insulin resistance in the diagnosis of polycystic ovary syndrome
| Project/Area Number |
15K10672
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IRAHARA Minoru 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (20160070)
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| Co-Investigator(Kenkyū-buntansha) |
松崎 利也 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (70294692)
岩佐 武 徳島大学, 病院, 特任准教授 (00707903)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 多嚢胞性卵巣症候群 / PCOS / 抗ミュラー管ホルモン / AMH / 年齢 |
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| Outline of Final Research Achievements |
We studied the significance of serum Anti-Mullerian hormone and insulin resistance (IR) in the diagnosis of polycystic ovary syndrome (PCOS). Serum AMH level was higher in PCOS than in normal cyclic women. Correlations between serum AMH level and various endocrine and metabolic factors (26 factors) were analysed in PCOS and 12 factors showed significant correlations with AMH although IR did not show significant correlation. Only ovarian volume showed the strongest positive correlation (r=0.62) with the serum AMH level on multiple regression analysis. A cut-off value of 10 ng/mL had a high specificity of 92.6%, although the sensitivity was low (24.6%). The serum AMH level could be a surrogate for ultrasound findings of the ovaries in the diagnosis of PCOS.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Multiple Androgen Biosynthesis Pathways Are Operating in Women with Polycystic Ovary Syndrome.2016
Author(s)
Saito K, Matsuzaki T, Iwasa T, Miyado M, Saito H, Hasegawa T, Homma K, Inoue E, Kubota T, Irahara M, Ogata T, Fukami M
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Journal Title
J Steroid Biochem Mol Biol
Volume: 158
Pages: 31-37
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The responses of hypothalamic NPY and OBRb mRNA expression to food deprivation develop during the neonatal-prepubertal period and exhibit gender differences in rats.2015
Author(s)
Matsuzaki T, Iwasa T, Tungalagsuvd A, Munkhzaya M, Kawami T, Yamasaki M, Murakami M, Kato T, Kuwahara A, Yasui T, Irahara M.
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Journal Title
Int J Dev Neurosci.
Volume: 41
Issue: 1
Pages: 63-67
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Developmental changes in hypothalamic oxytocin and oxytocin receptor mRNA expression and their sensitivity to fasting in male and female rats.2015
Author(s)
Matsuzaki T, Iwasa T, Munkhzaya M, Tungalagsuvd A, Kawami T, Murakami M, Yamasaki M, Yamamoto Y, Kato T, Kuwahara A, Yasui T, Irahara M.
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Journal Title
Int J Dev Neurosci.
Volume: 41
Issue: 1
Pages: 105-109
DOI
Related Report
Peer Reviewed / Open Access
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