Identification of labor-onset related mRNA/microRNA and its clinical significance
Project/Area Number |
15K10677
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Nagasaki University |
Principal Investigator |
MIURA Shoko 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (00404301)
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Co-Investigator(Kenkyū-buntansha) |
三浦 清徳 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (00363490)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | Labor / microRNA / plasma / placenta / prediction / 陣痛 / mRNA / 母体血漿 / 陣痛発来 / 分子マーカー / 産婦人科 / 胎盤 / 妊娠経過 / 基準値 |
Outline of Final Research Achievements |
Our study confirmed that C19MC microRNAs express from paternal allele. In addition, our data suggested that circulating level of cell-free miR-518b in maternal plasma is associated with the uterine stimulation. The circulating levels of cell-free C19MC microRNAs in maternal plasma increase as progress of pregnancy, and we could determined their reference values of C19MC microRNA in maternal plasma. Our data showed the possibility that the measurement of circulating C19MC microRNAs in maternal plasma makes it possible to predict the timing of labor-onset and to clarify the pathophysiology of labor-onset.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] A significant association between rs8067378 at 17q12 and invasive cervical cancer originally identified by a genome-wide association study in Han Chinese is replicated in a Japanese population2017
Author(s)
Miura K, Mishima H, Yasunami M, Kaneuchi M, Kitajima M, Abe, S, Fuchi N, Miura S, Yoshiura KI, Masuzaki H
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Journal Title
Journal of Human Genetics
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A significant association between rs8067378 at 17q12 and invasive cervical cancer originally identified by a genome-wide association study in Han Chinese is replicated in a Japanese population.2016
Author(s)
Miura K, Mishima H, Yasunami M, Kaneuchi M, Kitajima M, Abe S, Higashijima A, Fuchi N, Miura S, Yoshiura KI, Masuzaki H.
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Journal Title
J Hum Genet.
Volume: 61(9)
Issue: 9
Pages: 793-796
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Circulating levels of maternal plasma cell-free miR-21 are associated with maternal body mass index and neonatal birth weight2015
Author(s)
Miura K, Higashijima A, Hasegawa Y, Abe S, Miura S, Fuchi N, Murakami Y, Kinoshita A, Yoshida A, Kaneuchi M, Yoshiura KI, Masuzaki H
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Journal Title
Prenatal Diagnosis
Volume: 35
Pages: 509-511
Related Report
Peer Reviewed
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[Journal Article] Effect of labor on plasma concentrations and postpartum clearance of cell-free, pregnancy-associated, placenta-specific microRNAs2015
Author(s)
Morisaki S, Miura K, Higashijima A, Abe S, Miura S, Hasegawa Y, Yoshida A, Kaneuchi M, Yoshiura KI, Masuzaki H
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Journal Title
Prenatal Diagnosis
Volume: 35
Pages: 44-50
Related Report
Peer Reviewed
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