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The development of the novel strategy for venous thromboembolism in ovarian clear cell carcinomas

Research Project

Project/Area Number 15K10722
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKumamoto University

Principal Investigator

SAKAGUCHI ISAO  熊本大学, 医学部附属病院, 講師 (40448527)

Co-Investigator(Kenkyū-buntansha) 田代 浩徳  熊本大学, 大学院生命科学研究部(保), 教授 (70304996)
片渕 秀隆  熊本大学, 大学院生命科学研究部(医), 教授 (90224451)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords卵巣癌 / 明細胞癌 / 静脈血栓塞栓症 / 卵巣明細胞癌 / ARID1A / 血栓塞栓症 / 卵巣明細胞腺癌 / 子宮内膜症
Outline of Final Research Achievements

A venous thromboembolism (VTE) is prevalent in patients with ovarian clear cell carcinomas (OCCC). We investigated incidence, clinical pattern and outcome and detected risk factors for VTE in association with ovarian cancer. In ovarian cancer patients, univariate and multivariate analysis revealed that D-dimer>1.5ug/ml and OCCC were risk factors for VTE.ARID1A mutations in OCCC was reported in previous studies. The aim of this study was to identify genes correlated with expression of ARID1A in OCCC with VTE. We investigated the relationship between ARID1A and candidate protein (TM4SF1, MCAM, PPP3CA and KRAT15) identified by using DNA microarray technology. Consequently, ARID1A expression was not significantly associated with candidate proteins (TM4SF1, MCAM, PPP3CA and KRAT15) in OCCC.

Academic Significance and Societal Importance of the Research Achievements

卵巣癌明細胞癌における静脈血栓塞栓症の合併が他の組織型に比べて高率であることが改めて確認された。卵巣明細胞癌ではARID1A遺伝子が40%程度変異していることが知られているが、今回の研究では静脈血栓塞栓症とARIDA1遺伝子変異を結びつける新たな分子の同定には至らなかった。
卵巣癌の周術期または術後の追加治療としての抗癌化学療法の際に静脈血栓塞栓症を合併していることは全身管理の観点から致死性の危険因子の一つと捉えられてる。今後さらなる研究の継続を行い、静脈血栓塞栓症の原因検索とその予防方法を模索すべきである。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2018 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] High-dose oral tegafur-uracil maintenance therapy in patients with uterine cervical cancer.2015

    • Author(s)
      Sakaguchi I, Motohara T, Saito F, Takaishi K, Fukumatsu Y, Tohya T, Shibata S, Mimori H, Tashiro H, Katabuchi H.
    • Journal Title

      J Gynecol Oncol.

      Volume: 26 Pages: 193-200

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD44 variant 6 is correlated with peritoneal dissemination and poor prognosis in patients with advanced epithelial ovarian cancer.2015

    • Author(s)
      Tjhay F, Motohara T, Tayama S, Narantuya D, Fujimoto K, Guo J, Sakaguchi I, Honda R, Tashiro H, Katabuchi H.
    • Journal Title

      Cancer Sci. 2015 Oct;106(10):1421-8.

      Volume: 106 Pages: 1421-1428

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical comparisons of treatment strategies for advanced endometrial cancer in different countries2018

    • Author(s)
      Isao Sakaguchi
    • Organizer
      The 6th International Conference of Federation of Asian Clinical Oncology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-03-30  

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