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Analysis of molecular biological and tumor immunological characteristics of HPV negative cervical adenocarcinoma

Research Project

Project/Area Number 15K10729
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

IWATA Takashi  慶應義塾大学, 医学部(信濃町), 講師 (30296652)

Co-Investigator(Kenkyū-buntansha) 藤田 知信  慶應義塾大学, 医学部(信濃町), 助教 (20199334)
川井田 みほ  慶應義塾大学, 医学部(信濃町), 助教 (30767025)
Co-Investigator(Renkei-kenkyūsha) KAWAKAMI Yutaka  慶應義塾大学, 医学部, 教授 (50161287)
KUKIMOTO Iwao  国立感染症研究所, 病原体ゲノム解析研究センター, 室長 (70291127)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsHPV陰性子宮頸癌 / 診断 / 胃型腺癌 / 細胞内シグナル / 子宮頸部HPV陰性腺癌 / オントロジー / 子宮頸部腺癌 / HPV / 子宮頸癌 / HPV陰性腺癌
Outline of Final Research Achievements

HPV negative adenocarcinoma accounts for approximately 30% of cervical adenocarcinomas, and the age of onset is older than those with HPV positive cases.FIGO stage of HPV negative adenocarcinom tend to be progressive cases. The majority of HPV negative adenocarcinomas localized in the cervical canal and was difficult to detected by colposcopy. In immunohistochemistry of HIK1083, p53, p16, Ki-67, MUC6 in 20 cases of negative adenocarcinoma, the positive rate was HIK 1083:40%, p53:40%, p16:75%, Ki-67: 50%, MUC6:60%. Immune cell infiltration was not different between positive adenocarcinoma and HPV negative adenocarcinoma in all of CD4, CD8, CD20, FOXP3. As a result of microarray, EIF2 signal was activated in HPV negative adenocarcinoma

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results)

  • [Presentation] HPV陰性子宮頸部腺癌の臨床病理学的特徴2016

    • Author(s)
      飯島朋子、岩田卓、ほか
    • Organizer
      第58回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      米子コンベンションセンター(鳥取県米子市)
    • Year and Date
      2016-07-08
    • Related Report
      2016 Research-status Report
  • [Presentation] HPV陰性子宮頸部腺癌の臨床病理学的特徴と診断上の問題点2016

    • Author(s)
      飯島朋子、岩田卓、ほか
    • Organizer
      第131回 関東連合産科婦人科学会 総会・学術集会
    • Place of Presentation
      都市センターホテル(東京都千代田区)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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