Novel immunotherapy targeting monocyte and HLA-G for head and neck cancer
| Project/Area Number |
15K10798
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腫瘍免疫 / 単球 / HLA-G / PD-L1 / Intermediate monocyte / CD16 / CD51 / MFG-E8 / 頭頸部癌 / 免疫抑制 / 血管新生 |
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| Outline of Final Research Achievements |
Roles of circulating monocytes in patients with cancer have been still unclear. This study investigated expressions of molecules in monocytes and primary tumors in head and neck cancer patients to elucidate features of monocyte subsets.
As a result, proportion of Intermediate monocyte was decreased and expressions of immunosuppressive molecules was increased in cancer patients. Moreover, Intermediate monocyte was immature in patients with cancer, and that was associated with unfavorable prognosis. These results suggest that control of monocyte may be a novel target of cancer immunotherapy, and were also confirmed in vitro experiments. A part of the results have been reported in scientific meetings, are ready to submit to an international journal.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Impact of a Multidisciplinary Round Visit for the Management of Dysphagia Utilizing a Wi-Fi-Based Wireless Flexible Endoscopic Evaluation of Swallowing.2017
Author(s)
Sakakura K, Tazawa M, Otani N, Takagi M, Morita M, Kurosaki M, Chiyoda T, Kanai Y, Endo A, Murata T, Shino M, Yokobori Y, Shirakura K, Wada N, Chikamatsu K.
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 126
Pages: 47-53
Related Report
Peer Reviewed
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[Journal Article] Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma.2015
Author(s)
Nikkuni O, Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, Tominaga H, Oriuchi N, Suzuki M, Iijima M, Asao T, Nishiyama M, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
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Journal Title
Pathol Oncol Res
Volume: 21
Issue: 4
Pages: 1175-1181
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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