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Development of novel therapeutic strategies in head and neck squamous cell carcinoma based on microRNA-mediated cancer pathways

Research Project

Project/Area Number 15K10801
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionChiba University

Principal Investigator

SEKI NAOHIKO  千葉大学, 大学院医学研究院, 准教授 (50345013)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsマイクロRNA / 頭頸部扁平上皮癌 / 癌抑制遺伝子 / インテグリン / 発現プロファイル / 機能性RNA / 癌抑制型マイクロRNA / 癌促進型マイクロRNA / 治療抵抗性 / EGFR / c-MET / MET / シグナル伝達 / 受容体
Outline of Final Research Achievements

In this study, we construct the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). Our signature revealed that a total of 160 miRNAs (44 upregulated and 116 downregulated) were aberrantly expressed in cancer tissues. Expression of miR-150-5p (guide strand miRNA) and miR-150-3p (passenger strand miRNA) were significantly silenced in cancer tissues. Ectopic expression of mature miRNAs, miR-150-5p and miR-150-3p inhibited cancer cell aggressiveness. We identified that integrin α3 (ITGA3) and integrin α6 (ITGA6) were coordinately regulated by these miRNAs in HNSCC cells.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Remarks (2 results)

  • [Journal Article] Passenger strand of miR-145-3p acts as a tumor-suppressor by targeting MYO1B in head and neck squamous cell carcinoma2018

    • Author(s)
      Yamada Y, Koshizuka K, Hanazawa T, Kikkawa N, Okato A, Idichi T, Arai T, Sugawara S, Katada K, Okamoto Y, Seki N.
    • Journal Title

      International Journal of Oncology

      Volume: 52 Pages: 166-178

    • DOI

      10.3892/ijo.2017.4190

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs.2017

    • Author(s)
      Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Okamoto Y, Seki N.
    • Journal Title

      Oncotarget

      Volume: 印刷中 Issue: 18 Pages: 30288-30304

    • DOI

      10.18632/oncotarget.16327

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer2017

    • Author(s)
      Koshizuka Keiichi、Hanazawa Toyoyuki、Kikkawa Naoko、Arai Takayuki、Okato Atsushi、Kurozumi Akira、Kato Mayuko、Katada Koji、Okamoto Yoshitaka、Seki Naohiko
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 8 Pages: 1681-1692

    • DOI

      10.1111/cas.13298

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of integrin &#x3B2;1-mediated oncogenic signalling by the antitumor <i>microRNA-29</i> family in head and neck squamous cell carcinoma2017

    • Author(s)
      Koshizuka Keiichi、Kikkawa Naoko、Hanazawa Toyoyuki、Yamada Yasutaka、Okato Atsushi、Arai Takayuki、Katada Koji、Okamoto Yoshitaka、Seki Naohiko
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 3 Pages: 3663-3676

    • DOI

      10.18632/oncotarget.23194

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma.2017

    • Author(s)
      Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Matsushita R, Mataki H, Mizuno K, Okamoto Y, Seki N.
    • Journal Title

      Journal of Human Genetics

      Volume: 62 Issue: 1 Pages: 113-121

    • DOI

      10.1038/jhg.2016.47

    • NAID

      40021036343

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma.2016

    • Author(s)
      Fukumoto I, Koshizuka K, Hanazawa T, Kikkawa N, Matsushita R, Kurozumi A, Kato M, Okato A, Okamoto Y, Seki N.
    • Journal Title

      Int J Oncol.

      Volume: 49(3) Issue: 3 Pages: 1119-29

    • DOI

      10.3892/ijo.2016.3602

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma2016

    • Author(s)
      Ichiro Fukumoto, Naoko Kikkawa, Ryosuke Matsushita, Mayuko Kato, Akira Kurozumi, Rika Nishikawa, Yusuke Goto, Keiichi Koshizuka, Toyoyuki Hanazawa, Hideki Enokida, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki
    • Journal Title

      Journal of Human Genetics

      Volume: 61 Issue: 2 Pages: 109

    • DOI

      10.1038/jhg.2015.120

    • NAID

      40020742209

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MicroRNA expression signature of oral squamous cell carcinoma: Functional role of microRNA-26a/b in the modulation of novel cancer pathways2015

    • Author(s)
      Fukumoto I, Hanazawa T, Kinoshita T, Kikkawa N, Koshizuka K, Goto Y, Nishikawa R, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
    • Journal Title

      Br J Cancer

      Volume: 112 Issue: 5 Pages: 891

    • DOI

      10.1038/bjc.2015.19

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Remarks] 千葉大学大学院医学研究院 機能ゲノム学

    • URL

      http://genomejet.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院、機能ゲノム学

    • URL

      http://genomejet.jp/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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