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Regenerative medicine therapy by squamous cell sheet transplantation for artificial ulcer by endoscopic assisted surgery for pharyngeal cancer

Research Project

Project/Area Number 15K10808
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionTokyo Women's Medical University

Principal Investigator

Keisuke Hori  東京女子医科大学, 医学部, 研究生 (30749651)

Co-Investigator(Kenkyū-buntansha) 岡田 裕之  岡山大学, 医歯薬学総合研究科, 教授 (60263563)
河原 祥朗  岡山大学, 大学病院, 准教授 (30420483)
高木 章乃夫  岡山大学, 医歯薬学総合研究科, 准教授 (80359885)
岩室 雅也  岡山大学, 大学病院, 助教 (30645403)
木股 敬裕  岡山大学, 医歯薬学総合研究科, 教授 (50392345)
小野田 友男  岡山大学, 大学病院, 助教 (20420482)
Co-Investigator(Renkei-kenkyūsha) KANAI Nobuo  東京女子医科大学, 医学部, 特任講師 (90318056)
Research Collaborator ABE Makoto  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords再生医療 / 咽頭癌 / 経口的治療 / 内視鏡 / 細胞シート / 内視鏡治療
Outline of Final Research Achievements

With the improvement of the endoscope technology, transoral surgery supported by endoscopy is widely spreaded as the less invasive therapeutic method for the pharynx superficial cancer. To prevent early complications by inflammations and late complications by scar contracture we conducted the non-clinical study of squamous epithelium cell sheet transplantation for porcine model to show the anti-inflammatory action, and inhibition of excessive fibrosis. To transplant cell sheets onto entire field of the pharynx after procedure, novel devices were designed and developed with a 3-D printer. Successful cell sheets transplantation are conducted for all models and the effect of transplantation has been confirmed. We obtained non-clinical proof of consent which lead to the clinical application.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Presentation (6 results) (of which Int'l Joint Research: 3 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 当院での咽頭表在癌に対する咽頭ESDの治療成績2017

    • Author(s)
      安部真、河原祥朗、岡田裕之
    • Organizer
      日本消化器内視鏡学会中国支部例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 機器開発による細胞シート医療の咽頭領域への展開2016

    • Author(s)
      安部 真、金井 信雄、大和 雅之、岡田 裕之
    • Organizer
      第15回 日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場 (大阪府・大阪市北区)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Epithelial Cell Tissue Products for Prevention of Post-ESD Complications in the Area of Pharynx2016

    • Author(s)
      Makoto Abe, Nobuo Kanai, Keisuke Hori, Yoshiro Kawahara, Masayuki Yamato, Hiroyuki Okada
    • Organizer
      DDW2016
    • Place of Presentation
      サンディエゴ(アメリカ合衆国)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 消化管領域における上皮細胞シート製品の有効性と新たな展開2016

    • Author(s)
      安部 真、金井 信雄、岡田 裕之
    • Organizer
      JDDW2016
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市中央区)
    • Related Report
      2016 Research-status Report
  • [Presentation] The development of a novel device for transplantation of cell sheets in the field of the oropharynx and hypopharynx2015

    • Author(s)
      Makoto Abe, Masanori Maeda, Nobuo Kanai, Keisuke Hori, Yoshiro Kawahara, Hiroyuki Okada, Masayuki Yamato
    • Organizer
      23th UEG week Barcelona
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The development of a novel device for transplantation of cell sheets in the field of the oropharynx and hypopharynx2015

    • Author(s)
      Makoto Abe, Masanori Maeda, Nobuo Kanai, Keisuke Hori, Yoshiro Kawahara, Hiroyuki Okada, Masayuki Yamato
    • Organizer
      4th TERMIS world congress
    • Place of Presentation
      ボストン(アメリカ合衆国)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 治療物質運搬デバイス、および治療物質運搬キット2015

    • Inventor(s)
      前田真法、金井信雄、安部真、藤井祐介、大和雅之
    • Industrial Property Rights Holder
      前田真法、金井信雄、安部真、藤井祐介、大和雅之
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-177993
    • Filing Date
      2015-09-09
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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