Actin cytoskeleton control by a HNSCC stem cell marker CD271

• Project/Area Number: 15K10830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Matsuura Kazuto 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員 (70271947)
• Co-Investigator(Kenkyū-buntansha): 田中 伸幸 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 部長 (60280872)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 頭頸部癌 / 癌幹細胞 / 細胞骨格 / 頭頸部外科 / 細胞遊走 / 癌 / アクチン

Outline of Final Research Achievements

CD271 is a candidate cancer stem cell marker for HNSCC, but its functional role is left undetermined. By a co-purificaton approach, we identified Cortactin as a binding partner. CD271 positive cells expressed Cortactin, and cortactin-low cells showed decreased tumorigenesis and motility, which is similar to the CD271-loss phenotypes. Notably, actin network was damaged in cortactin-low cells. These results suggest CD271 and cortactin are potential therapeutic targets of head and neck cancer.

Research Products

• [Journal Article] Laryngeal function-preserving operation for T4a laryngeal cancer with vocal cord paralysis ? A case report (2018)
  • Author(s): Asada Yukinori、Kurosawa Koreyuki、Matsumoto Ko、Goto Takahiro、Katoh Kengo、Imai Takayuki、Saijo Shigeru、Matsuura Kazuto
  • Journal Title: Auris Nasus Larynx Volume: 45 Issue: 1 Pages: 194-199
  • DOI: 10.1016/j.anl.2017.03.012
  • Peer Reviewed
• [Journal Article] Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (Japan Clinical Oncology Group 1212): Dose-finding phase (2017)
  • Author(s): Homma Akihiro、Onimaru Rikiya、Matsuura Kazuto、Shinomiya Hirotaka、Sakashita Tomohiro、Shiga Kiyoto、Tachibana Hiroyuki、Nakamura Kenichi、Mizusawa Junki、Kitahara Hideaki、Eba Junko、Fukuda Haruhiko、Fujii Masato、Hayashi Ryuichi
  • Journal Title: Head & Neck Volume: 40 Issue: 3 Pages: 475-484
  • DOI: 10.1002/hed.25001
  • NAID: 120006558995
  • Peer Reviewed
• [Journal Article] A Novel Funnel-Shaped Flap for Reconstruction Surgery after Total Laryngopharyngectomy with Total Glossectomy (2017)
  • Author(s): Kurosawa Koreyuki、Asada Yukinori、Matsumoto Ko、Imai Takayuki、Matsuura Kazuto、Goto Takahiro
  • Journal Title: Plastic and Reconstructive Surgery - Global Open Volume: 5 Issue: 9 Pages: e1504-e1504
  • DOI: 10.1097/gox.0000000000001504
  • Peer Reviewed
• [Journal Article] Expression of cell cycle-related proteins in oropharyngeal squamous cell carcinoma based on human papilloma virus status (2017)
  • Author(s): Tsuchida, K. Sugai, T. Uesugi, N. Ishida, K. Matsuura, K. Sato, I. Shiga, K. Sato, H.
  • Journal Title: Oncol Rep Volume: 38 Issue: 2 Pages: 908-916
  • DOI: 10.3892/or.2017.5720
  • Peer Reviewed / Open Access
• [Journal Article] Matched-pair analysis of patients with advanced hypopharyngeal cancer: surgery versus concomitant chemoradiotherapy. (2017)
  • Author(s): Iwae S, Fujii M, Hayashi R, Hasegawa Y, Fujii T, Okami K, Homma A, Onitsuka T,
  • Journal Title: Int J Clin Oncol. Volume: 22 Issue: 6 Pages: 1001-1008
  • DOI: 10.1007/s10147-017-1151-9
  • Peer Reviewed
• [Journal Article] Efficacy and safety of rebamipide liquid for chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II study (2017)
  • Author(s): Yokota T.、Ogawa T.、Takahashi S.、Okami K.、Fujii T.、Tanaka K.、Iwae S.、Ota I.、Ueda T.、Monden N.、Matsuura K.、Kojima H.、Ueda S.、Sasaki K.、Fujimoto Y.、Hasegawa Y.、Beppu T.、Nishimori H.、Hirano S.、Naka Y.、Matsushima Y.、Fujii M.、Tahara M.
  • Journal Title: BMC Cancer Volume: 17 Issue: 1 Pages: 314-314
  • DOI: 10.1186/s12885-017-3295-4
  • Peer Reviewed
• [Journal Article] CD271 regulates the proliferation and motility of hypopharyngeal cancer cells (2016)
  • Author(s): Mochizuki M, Tamai K, Imai T, Sugawara S, Ogama N, Nakamura M, Matsuura K, Yamaguchi K, Satoh K, Sato I, Motohashi H, Sugamura K, Tanaka N
  • Journal Title: Sci Reｐ Volume: 6 Issue: 1 Pages: 30707-30707
  • DOI: 10.1038/srep30707
  • Peer Reviewed / Open Access
• [Journal Article] Quality of life and functional status of terminally ill head and neck cancer patients: a nation-wide, prospective observational study at tertiary cancer centers in Japan. (2016)
  • Author(s): Takeshi Shinozaki, Mitsuru Ebihara, Satoru Iwase, Takuhiro Yamaguchi, Hitoshi Hirakawa, Wataru Shimbashi, Tomoyuki Kamijo, Makito Okamoto, Takeshi Beppu, Junichiro Ohori, Kazuto Matsuura, Motoyuki Suzuki, Hiroshi Nishino, Yuichiro Sato and Hiroto Ishiki
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 2016 Issue: 1 Pages: 1-7
  • DOI: 10.1093/jjco/hyw138
  • Acknowledgement Compliant
• [Journal Article] Late-onset dysphagia caused by severe spastic peristalsis of a free jejunal graft in a case of hypopharyngeal cancer. (2016)
  • Author(s): Imai T, Goto T, Matsumoto K, Kurosawa K, Asada Y, Saijo S, Matsuura K.:
  • Journal Title: Auris Nasus Larynx. Volume: 43 Issue: 6 Pages: 693-697
  • DOI: 10.1016/j.anl.2016.03.011
  • Acknowledgement Compliant
• [Journal Article] Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma. (2016)
  • Author(s): Akihiro Homma, Ryuichi Hayashi, Kazuyoshi Kawabata, Takashi Fujii, Shigemichi Iwae, Yasuhisa Hasegawa, Kenichi Nibu, Takakuni Kato, Kiyoto Shiga, Kazuto Matsuura, Nobuya Monden, Masato Fujii
  • Journal Title: Head Neck. Volume: 38 Issue: 10 Pages: 1495-1500
  • DOI: 10.1002/hed.24467
  • NAID: 120006347204
  • Acknowledgement Compliant
• [Presentation] S100A10 regulates malignant phenotype of head and neck squamous cell carcinoma (HNSCC) (2017)
  • Author(s): Naoko Ogama, Taketo Nishikawaji, Katsuhiko Kojima, Kazuto Matsuura, Nobuyuki Tanaka
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 頭頸部癌においてCD271は増殖・浸潤を制御する (2016)
  • Author(s): 望月麻衣 玉井恵一、今井隆之、小鎌直子、中村真央、松浦一登、山口壹範、佐藤賢一、 佐藤郁郎、菅村和夫、田中伸幸
  • Organizer: 第39回 日本分子生物学会 年会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-12-02
• [Presentation] 頭頸部超音波検査の教育体制を考える (2016)
  • Author(s): 松浦一登
  • Organizer: 第37回日本乳腺甲状腺超音波医学会
  • Place of Presentation: 川越市
  • Year and Date: 2016-10-15
• [Presentation] 口腔咽頭癌のマネージメント-治療法の変遷と予後評価を中心に- エキスパート・オピニオン．中咽頭癌治療の現状とこれから (2016)
  • Author(s): 松浦一登
  • Organizer: 第29回日本口腔咽頭科学会
  • Place of Presentation: 松江市
  • Year and Date: 2016-09-08
• [Book] JOHNS (2016)
  • Author(s): 松浦一登
  • Total Pages: 4
  • Publisher: 東京医学社
• [Book] ENTONI (2016)
  • Author(s): 松浦一登
  • Total Pages: 5
  • Publisher: 全日本病院出版会
• [Book] 日本耳鼻咽喉科学会会報 (2016)
  • Author(s): 松浦一登
  • Total Pages: 2
  • Publisher: 一般社団法人 日本耳鼻咽喉科学会