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Assessment of oxidative stress in samples from glaucoma patients

Research Project

Project/Area Number 15K10866
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionShimane University

Principal Investigator

TANITO MASAKI  島根大学, 医学部, 客員研究員 (30284037)

Co-Investigator(Kenkyū-buntansha) 大平 明弘  島根大学, 医学部, 教授 (00169054)
海津 幸子  島根大学, 医学部, 助教 (00325052)
Co-Investigator(Renkei-kenkyūsha) YOSHIDA Yasukazu  産業技術総合研究所, 健康工学部門, 部門長 (90358333)
Research Collaborator UMENO Aya  産業技術総合研究所, 健康工学部門, 特別研究員 (20749098)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords緑内障 / 酸化ストレス
Outline of Final Research Achievements

The involvement of local and systemic oxidative stress in intraocular pressure (IOP) elevation and optic nerve damage has been hypothesized in the pathogenesis of glaucoma. Here, we assessed the correlation between IOP and systemic levels of prooxidants and antioxidants by analyzing the blood biochemistry in patients with glaucoma.Peripheral blood samples were collected from Japanese patients with primary open-angle glaucoma (n=206), exfoliation syndrome (n=199), and controls (n=126). Serum levels of lipid peroxides, ferric-reducing activity, and thiol antioxidant activity were measured by diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and sulfhydryl (SH) tests, respectively, using a free radical analyzer. Lower systemic antioxidant capacity measured by ferric-reducing activity is involved in the pathogenesis of open-angle glaucoma via its roles in IOP elevation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Dean McGee Eye Institute(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Association between systemic oxidative stress and visual field damage in open-angle glaucoma.2016

    • Author(s)
      Tanito M, Kaidzu S, Takai Y, Ohira A.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 25792-25792

    • DOI

      10.1038/srep25792

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Correlation between Systemic Oxidative Stress and Intraocular Pressure Level2015

    • Author(s)
      Masaki Tanito, Sachiko Kaidzu, Yasuyuki Takai, Akihiro Ohira
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 7 Pages: e0133582-e0133582

    • DOI

      10.1371/journal.pone.0133582

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ヒドロキシリノール酸をバイオマーカーとした緑内障への酸化ストレスの関与解明2017

    • Author(s)
      梅野彩,谷戸正樹,吉田康一
    • Organizer
      第28回眼科酸化ストレス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒドロキシリノール酸による緑内障への酸化ストレスの関与2017

    • Author(s)
      梅野彩,谷戸正樹,吉田康一
    • Organizer
      第70回日本酸化ストレス学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Correlation between systemic oxidative stresses and intraocular pressure level.2015

    • Author(s)
      Tanito M, Kaidzu S, Takai Y, Ohira A
    • Organizer
      ARVO 2015 Annual Meeting
    • Place of Presentation
      Denver, CO (アメリカ)
    • Year and Date
      2015-05-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2022-01-24  

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