Microbiome analysis of apical periodontitis and cellulitis in oral cavity
| Project/Area Number |
15K11023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
村松 敬 東京歯科大学, 歯学部, 准教授 (00276982)
菊池 有一郎 東京歯科大学, 歯学部, 助教 (30410418)
柴山 和子 東京歯科大学, 歯学部, 講師 (60408317)
国分 栄仁 東京歯科大学, 歯学部, 講師 (70453785)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Yoshihisa 九州大学, 歯学部, 教授 (20192403)
MURAMATSU Kyotaro 東京歯科大学, 歯学部, 助教 (90507328)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 根尖性歯周炎 / マイクロバイオーム / 16S rRNA pyrosequencing / Prevotella / Porphyromonas / Fusobacterium / Parvimonas / Polymicrobial infection / 網羅的解析 / Pyrosequencing / Dysbiosis / 細菌叢 / 口腔底蜂窩織炎 / 歯根嚢胞 / 蜂窩織炎 / メタ16S rRNA 解析 / 口腔細菌 / 歯周炎 / バイオフィルム / Quorum sensing |
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| Outline of Final Research Achievements |
In the lesion of apical periodontitis, approximately 55 species of bacteria were detected. Among them, predominant genera were Prevotella, Porphyromonas, Parvimonas, Peptostreptococcus, Fusobacterium. The microbiome was different between the lesion in single space and the lesion with multi space. We also detected the difference in microbiome between the lesion with bleeding and the lesion with discharge of pus. These data suggest the association between the clinical condition and microbiome of the lesion.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis2017
Author(s)
Morita M, Iwasaki R, Sato Y, Kobayashi T, Watanabe R, Oike T, Nakamura S, Keneko Y, Miyamoto K, Ishihara K, Iwakura Y, Ishii K, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto T.
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 46322-46322
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Regulation of gene expression by marR-like gene in Treponema denticola2017
Author(s)
Numata, Y. Okamoto-Shibayama, K. Sato, T. Miyai-Murai, Y. Kikuchi, Y. Kokubu, E. Ishihara, K.
Organizer
95th IADR/AADR/CADR General Session, San Francisco, Calif., USA
Related Report
Int'l Joint Research
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[Presentation] 知的障害者に対する経口アジスロマイシン投与を併用したOne-stage full-mouth disinfectionの効果2015
Author(s)
関野仁, 重枝昭広, 石井里加子, 小暮弘子, 吉岡真由美, 笹川百吏子, 荒井綾子, 後藤悦子, 岩佐美里, 森谷佳織, 八島章博, 長野孝俊, 中川種昭, 石原和幸, 齋藤淳, 五味一博
Organizer
第58回春季日本歯周病学会学術大会
Place of Presentation
千葉
Year and Date
2015-05-15
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[Book] 病原細菌・ウイルス図鑑2017
Author(s)
石原和幸、奥田克爾 著 分担
Total Pages
916
Publisher
北海道大学出版会
ISBN
9784832982291
Related Report
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