| Project/Area Number |
15K11023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
村松 敬 東京歯科大学, 歯学部, 准教授 (00276982)
菊池 有一郎 東京歯科大学, 歯学部, 助教 (30410418)
柴山 和子 東京歯科大学, 歯学部, 講師 (60408317)
国分 栄仁 東京歯科大学, 歯学部, 講師 (70453785)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Yoshihisa 九州大学, 歯学部, 教授 (20192403)
MURAMATSU Kyotaro 東京歯科大学, 歯学部, 助教 (90507328)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 根尖性歯周炎 / マイクロバイオーム / 16S rRNA pyrosequencing / Prevotella / Porphyromonas / Fusobacterium / Parvimonas / Polymicrobial infection / 網羅的解析 / Pyrosequencing / Dysbiosis / 細菌叢 / 口腔底蜂窩織炎 / 歯根嚢胞 / 蜂窩織炎 / メタ16S rRNA 解析 / 口腔細菌 / 歯周炎 / バイオフィルム / Quorum sensing |
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| Outline of Final Research Achievements |
In the lesion of apical periodontitis, approximately 55 species of bacteria were detected. Among them, predominant genera were Prevotella, Porphyromonas, Parvimonas, Peptostreptococcus, Fusobacterium. The microbiome was different between the lesion in single space and the lesion with multi space. We also detected the difference in microbiome between the lesion with bleeding and the lesion with discharge of pus. These data suggest the association between the clinical condition and microbiome of the lesion.
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