Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Outline of Final Research Achievements |
Amelogenin is one of proteins of enamel matrices and may play a key role in the maintenance of periodontal tissues. It has been still unknown the mechanism of suppressing osteoclastgenesis with amelogenin. Our study shows that chemical synthesized LRAP, one of amelogenin splicing isoforms suppressed the osteoblast cell proliferation but there is no difference between the control and the presence of LAMP-1 antibody. LRPA have no apparent effect on osteclastgenesis but the expression of Grp78, one of amelogenin binding protein, was increased in periodontal ligament cell during periodontal tissues development.
|