Renin-angiotensin system in peripheral taste organ
| Project/Area Number |
15K11044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 味覚 / 塩味 / アンジオテンシン / レニン / アンジオテンシノゲン / アンジオテンシン変換酵素 |
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| Outline of Final Research Achievements |
Renin-angiotensin system (RAS) plays a major role in the regulation of body fluid and sodium homeostasis. Angiotensin II (AngII) is a biologically active product of the RAS. We recently revealed that AngII suppresses salt taste responses and enhances sweet taste responses via the angiotensin II receptor expressed in taste cells. However, the underlying molecular mechanisms on such taste modulations remain unknown. Here we examined the expression of RAS components producing AngII, renin, angiotensinogen and angiotensin converting enzyme, in mouse taste tissues. We found that all of RAS components were present in taste buds, and co-expressed with salt and sweet taste receptors. The expression level of Renin in taste cells increased significantly after water deprivation. These results suggest that taste organ exhibits their own RAS activity, and the specific modulation of taste sensitivity is regulated by the taste RAS, which may play important roles in sodium/calorie homeostasis.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides.2016
Author(s)
Sukumaran SK, Yee KK, Iwata S, Kotha R, Quezada-Calvillo R, Nichols BL, Mohan S, Pinto BM, Shigemura N, Ninomiya Y, Margolskee RF.
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Journal Title
Proceedings of the National Academy of Sciences.
Volume: 113
Issue: 21
Pages: 6035-6040
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 味覚受容体の機能（塩味と甘味）2016
Author(s)
重村 憲徳, 吉田 竜介, 安松 啓子, 大栗 弾宏, 岩田 周介, 高井 信吾, 上瀧 将史, 仁木 麻由, 實松 敬介, 二ノ宮 裕三
Organizer
日本薬学会第136年会
Place of Presentation
横浜
Year and Date
2016-03-26
Related Report
Invited
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[Presentation] ホルモンによる味覚（塩味・甘味）感受性調節2015
Author(s)
重村 憲徳, 吉田 竜介, 安松 啓子, 大栗 弾宏, 岩田 周介, 高井 信吾, 上瀧 将史, 仁木 麻由, 實松 敬介, 二ノ宮 裕三
Organizer
第67回日本生物工学会大会
Place of Presentation
鹿児島
Year and Date
2015-10-26
Related Report
Invited
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