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Molecular mechanism of nerve regeneration and sensory disorder following axonal injury

Research Project

Project/Area Number 15K11057
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionNihon University

Principal Investigator

KONDO Masahiro  日本大学, 歯学部, 講師 (50312294)

Project Period (FY) 2015-10-21 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords軸索損傷 / 神経回路 / 下歯槽神経 / 三叉神経脊髄路核 / ERK / 神経損傷 / 細胞接着分子 / CGRP / IB4
Outline of Final Research Achievements

To study each process of anatomical, neurochemical and physiological regeneration after nerve injury, we developed a model of complete IAN transection (IANX) in mice. A subset of small TG neurons, i.e. C afferents, had re-innervated their appropriate receptive field within 2 weeks post-axotomy, and the peptidergic neurons regenerate more efficiently compared to non-peptidergic neurons after trigeminal nerve injury. On the other hand, head-withdrawal threshold (HWT) to noxious heat or pinch stimulation began to return toward basal level on day 14 after IANX, but did not recover completely. The distribution pattern of pinch stimuli-induced pERK-IR cells, i.e. second order neurons and/or interneurons, was altered in Vc at 2 weeks after IANX. We also found that the reduction in E-cadherin expression in Vc is correlated with increase of HWT to noxious stimuli after IANX.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Medullary neural circuit regeneration after trigeminal nerve transection2018

    • Author(s)
      Suzuki T, Kondo M, Shibuta I, Nagashima H, Sugano N, Sato S, Iwata K
    • Journal Title

      J Oral Sci

      Volume: 印刷中

    • NAID

      130007553063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity2017

    • Author(s)
      Honda Kuniya、Shinoda Masamichi、Kondo Masahiro、Shimizu Kohei、Yonemoto Hisashi、Otsuki Katsuhiko、Akasaka Ryuta、Furukawa Akihiko、Iwata Koichi
    • Journal Title

      Pain

      Volume: 158 Issue: 9 Pages: 1754-1764

    • DOI

      10.1097/j.pain.0000000000000973

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Regeneration of orofacial sensory circuits following inferior alveolar nerve transection2018

    • Author(s)
      Tatsuro Suzuki, Masahiro Kondo, Hidekazu Nagashima, Naoyuki Sugano, Shuichi Sato, Koichi Iwata
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] E-cadherin expression advancing inferior alveolar nerve regeneration2017

    • Author(s)
      Tatsuro Suzuki, Masahiro Kondo, Naoyuki Sugano, Shuichi Sato, Koichi Iwata
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松アクトシティコングレスセンター(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Functional regeneration of afferent axons following inferior alveolar nerve transection2017

    • Author(s)
      Tatsuro Suzuki, Masahiro Kondo, Ayano Katagiri, Hidekazu Nagashima, Naoyuki Sugano, Shuichi Sato, Koichi Iwata
    • Organizer
      SFN2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 下歯槽神経の再生過程における細胞接着分子の発現変化2016

    • Author(s)
      鈴木達郎、近藤真啓、菅野直之、岩田幸一、佐藤秀一
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 下歯槽神経の再生過程における細胞接着分子の発現変化2015

    • Author(s)
      鈴木達郎、近藤真啓、菅野直之、佐藤秀一、岩田幸一
    • Organizer
      第9回三叉神経領域の感覚―運動統合機構研究会
    • Place of Presentation
      休暇村志賀島(福岡県福岡市)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report

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Published: 2015-10-21   Modified: 2019-03-29  

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