Development of the surface-improved dental implant with strong epithelial adhesion and antibacterial properties

• Project/Area Number: 15K11211
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NAKAISHI Michiko 東京医科歯科大学, 生体材料工学研究所, 技術職員 (60374550)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ポリリン酸 / ハイドロキシアパタイト（HA） / Streptococcus gordonii / 抗菌性 / ハイドロキシアパタイト(HA) / ポリリン酸ナトリウム / 上皮細胞

Outline of Final Research Achievements

Inorganic polyphosphate (Poly P) is a polymeric substance and is elaborated by chained phosphate. We aimed to create the hydroxyapatite(HA) dental implant coated with Poly P having antibacterial effect. Therefore, we examined the antibacterial effect of Poly P and HA coated with Poly P against Streptococcus gordonii that is a kind of periodontopathic bacterium. The averaged out chain length of 100 regarding a long chain Poly P had the most antibacterial effect and the minimum inhibitory concentration was 0.2wt%. HA coated 0.2wt% with an averaged out length of 100 concerning a long chain Poly P had a high antibacterial effect against Streptococcus gordonii.