BNCT suppressed the transition and invasion ability of the oral cancer cells.
| Project/Area Number |
15K11262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
Kirita Tadaaki 奈良県立医科大学, 医学部, 教授 (70201465)
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| Co-Investigator(Kenkyū-buntansha) |
仲川 洋介 奈良県立医科大学, 医学部, 研究員 (00714875)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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|---|
| Keywords | BNCT / BPA / 5-FU / がん治療 / ホウ素製剤 |
|---|
| Outline of Final Research Achievements |
Our animal experiments suggested thatthe advance administration of 5-FU does not have any impact on BPA accumulation in normal tissue, but it is suggested that this lowers BPA accumulation in tumor tissue. It is thought that the cell cycle in the G2/M cycle stopping due to 5-FU and the decrease in the expression of protein related to cell proliferation affected the metabolism of amino acids and was linked to a decrease in the absorption of BPA.
Additionally,in the animal experiments in which cancer cells were transplanted to mice, sequentially the tumors and normal tissue of the BPA administration group and the F-BPA administration group were taken, and, using ICP after the ashing process, the sequential changes in each of the tissues were approximated in both the BPA administration group and the F-BPA group. It was considered reasonable to expect boron accumulation of BPA in the PET examination using F-BPA, and to start up a BNCT treatment plan.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] BRCA2 protects mammalian cells from heat shock2018
Author(s)
Yosuke Nakagawa, Atsuhisa Kajihara, Akihisa Takahashi, Akiho S. Murata, Masaya Matsubayashi, Soichiro S. Ito, Ichiro Ota, Takahiko Nakagawa, Masatoshi Hasegawa, Tadaaki Kirita, Takeo Ohnishi, Eiichiro Mori
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Journal Title
Int J Hyperthermia
Volume: 印刷中
Issue: 6
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 口腔癌に対するセツキシマブの安全性と有効性に関する多施設共同後ろ向き観察研究2016
Author(s)
藤内 祝, 梅田 正博, 桐田 忠昭, 柳本 惣市, 山下 徹郎, 平塚 博義, 横尾 聡, 丹沢 秀樹, 鵜澤 成一, 柴原 孝彦, 高野 伸夫, 太田 嘉英, 栗田 浩, 大倉 正也, 関根 浄治, 浜川 裕之, 楠川 仁悟, 篠原 正徳
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Journal Title
日本口腔腫瘍学会誌
Volume: 28(4)
Pages: 169-179
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Multicenter Retrospective Study of Adjuvant Therapy for Patients with Pathologically Lymph Node-Positive Oral Squamous Cell Carcinoma: Analysis of Covariance Using Propensity Score.2015
Author(s)
Yanamoto S, Otsuru M, Ota Y, Okura M, Aikawa T, Kurita H, Kamata T, Kirita T, Yamakawa N, Ueda M, Yamashita T, Komori T, Shigeta T, Yokoo S, Ogawa M, Umeda M; Japan Oral Oncology Group.
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Journal Title
Ann Surg Oncol
Volume: Dec;22 Suppl 3
Issue: S3
Pages: 992-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 下顎骨切除後の再建法の選択2015
Author(s)
桐田忠昭, 山川延宏, 上田順宏, 柳生貴裕, 上山善弘, 今田光彦,今井裕一郎
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Journal Title
日本口腔腫瘍学会誌
Volume: ２７(3)
Pages: 41-48
Related Report
Peer Reviewed / Open Access
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