Challenge to inferior alveolar nerve regeneration by human iPS cells for feeder-free and xeno-free system
| Project/Area Number |
15K11267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Keio University |
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Principal Investigator |
Kawana Hiromasa 慶應義塾大学, 医学部(信濃町), 准教授 (50224803)
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| Co-Investigator(Kenkyū-buntansha) |
森川 暁 慶應義塾大学, 医学部(信濃町), 講師 (00424169)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 末梢神経再生 / 神経損傷 / 神経堤細胞 / iPS細胞 / 末梢神経損傷 / 細胞治療 / ゼノフリー培養法 / フィーダーフリー培養法 / 下歯槽神経再生 / フィーダーフリー / ゼノフリー |
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| Outline of Final Research Achievements |
The present study aims to induce neural crest cells from iPS cells and restore function of damaged nerve tissue. We established iPS cell culture method with feeder-free, xeno-free system for inducing neural crest cells. In order to investigate whether the induced neural crest cell population actually has the potential to restore peripheral nerve injury, we started the creation of the sciatic nerve cutting model and its functional evaluation. We found that transplanted induced neural crest cells possess the properties of mesenchymal stem cells and vascular endothelial cells that could also be induced into regenerating nerve tissues. These cells expressed peripheral nerve markers in transplantation tissues.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Purified Human Dental Pulp Stem Cells Promote Osteogenic Regeneration.2015
Author(s)
Yasui T, Mabuchi Y, Toriumi H, Ebine T, Niibe K, Houlihan DD, Morikawa S, Onizawa K, Kawana H, Akazawa C, Suzuki N, Nakagawa T, Okano H, Matsuzaki Y.
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Journal Title
journal of Dental Research
Volume: 95
Issue: 2
Pages: 206-214
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] LNGFR(+)THY-1(+) multipotent stem cells derived from human induced pluripotent stem cells2017
Author(s)
Ouchi, T. Shibata, S. Kimura, H. Nagoshi, N. Fujimura, Y. Morikawa, S. Sato, K. Kawana, H. Fukuda, K. Nakamura, M. Nakagawa, T. Okano, H.
Organizer
18th International Congress of Developmental Biology
Related Report
Int'l Joint Research
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