Basic study on tumor growth inhibitory effect of oral cancer by Sonodynamic therapy (SDT)

• Project/Area Number: 15K11282
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: Yoshida Kenji 愛知学院大学, 歯学部, 教授 (40183701)
• Co-Investigator(Kenkyū-buntansha): 中西 速夫 愛知県がんセンター(研究所), その他部局等, その他(移行) (20207830)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Sonodynamic Therapy / 口腔扁平上皮がん / 5-ALA / 培養細胞 / マウス / 抗腫瘍効果 / 超音波感受性物質 / 超音波遮蔽板 / 超音波力学療法（SDT) / 口腔扁平上皮癌 / 皮膚光線過敏症 / Sonodynamic Therap (SDT) / 口腔扁平上皮がん / 超音波力学療法 / 超短波プローブ / ヌードマウス皮下腫瘍モデル

Outline of Final Research Achievements

Recent advances of sonodynamic therapy(STD) in oral cancer treatment and its significance such as therapeutic effects are reported. In this study a unique SDT system was added to a commercially available ultrasonic irradiation device, and a new SDT system was constructed to conduct a basic study on its therapeutic effect.
As a result, the antitumor effect of SDT on human oral squamous cell carcinoma cell subcutaneously transplanted mice was confirmed, However it was considered that further research will be needed regarding the antitumor effect of the Sonodynamic sensitizer 5-ALA pretreatment + ultrasonic combination group