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Study of diagnostic imaging methods of cervical lymph nodes metastasis using new high resolusion 3D MR imaging

Research Project

Project/Area Number 15K11287
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionTohoku University

Principal Investigator

Kojima Ikuho  東北大学, 歯学研究科, 助教 (80447169)

Co-Investigator(Kenkyū-buntansha) 飯久保 正弘  東北大学, 歯学研究科, 講師 (80302157)
阪本 真弥  東北大学, 大学病院, 講師 (90157686)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsリンパ節転移 / MRI / 頭頸部癌 / 頸部リンパ節転移 / MR imaging
Outline of Final Research Achievements

We analyzed the usefulness of black-blood MR imaging (MSDE-VISTA) to detect small lymph node metastases in head and neck cancer, and obtained stable and good quality imaging with high resolution 3D imaging and blood flow artifact suppression.The MSDE-VISTA was superior to the conventional MR imaging in the ability to visualize focal defect and extranodal extension of the metastatic lymph nodes, which are findings suggestive of lymph node metastasis. Further, subtracion images of before and after contrast enhanced the MSDE-VISTA showed the best diagnostic performance. Thus, these results suggested that the MSDE-VISTA can detect early and accurately lymph node metastasis in imaging diagnosis of head and neck cancer.

Academic Significance and Societal Importance of the Research Achievements

頸部リンパ節転移の診断は、頭頸部がん患者に対する治療法の選択に極めて重要であり、生命予後に深く関わる。しかしながら、画像診断方法が飛躍的に進歩した今日でも、小さなリンパ節転移を的確に診断することは容易ではない。本研究によるリンパ節転移の精確な診断、早期診断が向上した成果は、現在の臨床において汎用性の高い画像検査であるMRIに即座に応用可能であり、頭頸部がん患者の生命予後の向上、ならびに不要な手術の回避に寄与する。また、本研究による3D-MRI検査方法は容易に各病院で応用可能であり、広く社会貢献が可能なものと考える。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2019 2018 2017 2016 2015 2009

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (7 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Relationship of MR Imaging of Submandibular Glands to Hyposalivation in Sjoegren’s Syndrome2019

    • Author(s)
      I Kojima, M Sakamoto, M Iikubo, Y Shimada, T Nishioka, T Sasano.
    • Journal Title

      Oral Diseases

      Volume: 25 Issue: 1 Pages: 117-125

    • DOI

      10.1111/odi.12941

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Takayasu Arteritis Coexisting with Sclerosing Osteomyelitis2018

    • Author(s)
      Shirai T, Hanaoka R, Goto Y, Kojima I, Ishii Y, Hoshi Y, Fujita Y, Shirota Y, Fujii H, Ishii T, Harigae H.
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 13 Pages: 1929-1934

    • DOI

      10.2169/internalmedicine.0329-17

    • NAID

      130007387190

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-07-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical utility of dynamic-enhanced MRI in salivary gland tumors: retrospective study and literature review.2018

    • Author(s)
      Ogawa T, Kojima I, Ishii R, Sakamoto M, Murata T, Suzuki T, Kato K, Nakanome A, Ohkoshi A, Ishida E, Kakehata S, Shiga K, Katori Y.
    • Journal Title

      Eur Arch Otorhinolaryngol.

      Volume: 印刷中 Issue: 6 Pages: 1613-1621

    • DOI

      10.1007/s00405-018-4965-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Six cases of head and neck osteosarcoma2018

    • Author(s)
      嵯峨井 俊、小川 武則、臼渕 肇、小嶋 郁穂、村田 隆紀、高橋 昌宏、西條 憲、加藤 健吾、中目 亜矢子、大越 明、東 賢二郎、石井 亮、香取 幸夫.
    • Journal Title

      JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY

      Volume: 27 Issue: 3 Pages: 379-385

    • DOI

      10.5106/jjshns.27.379

    • NAID

      130006496746

    • ISSN
      1349-581X, 1884-474X
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical utility of dynamic MRI in salivary gland tumors - retrospective study and literature review -2018

    • Author(s)
      T Ogawa, I Kojima, R Ishii, M Sakamoto, T Murata, T Suzuki, K Kato, A Nakanome, A Okoshi, E Ishida, S Kakehata, K Shiga and Y Katori.
    • Journal Title

      European Archives of Oto-Rhino-Laryngology

      Volume: In press

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic performance of MR imaging of three major salivary glands for Sjögren's syndrome.2017

    • Author(s)
      I Kojima I, M Sakamoto , M Iikubo , H Kumamoto, A Muroi, Y Sugawara, S Satoh-Kuriwada, T Sasano
    • Journal Title

      Oral diseases  2017 Jan;23(1):84-90

      Volume: 23 Issue: 1 Pages: 84-90

    • DOI

      10.1111/odi.12577

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evaluation of the enhanced permeability and retention effect in the early stages of lymph node metastasis2017

    • Author(s)
      Mikada M, Sukhbaatar, A, Miura Y, Horie S, Sakamoto M, Mori S, Kodama T
    • Journal Title

      Cancer Sci

      Volume: 印刷中 Issue: 5 Pages: 846-852

    • DOI

      10.1111/cas.13206

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MRIで悪性腫瘍箇所を同定し得た耳下腺多型腺腫由来癌の1例2016

    • Author(s)
      若盛 隼、小川 武則、臼渕 肇、阪本 真弥、小嶋 郁穂、村田 隆紀、嵯峨井 俊、中目 亜矢子、大越 明、東 賢二郎、石井 亮、白倉 真之、石川 智彦、香取 幸夫
    • Journal Title

      頭頸部外科

      Volume: 26 Pages: 389-393

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early diagnosis of lymph node metastasis: importance of intranodal pressures2016

    • Author(s)
      Miura Y, Mikada M, Ouchi T, Horie S, Takeda K, Yamaki T, Sakamoto M, Mori S, Kodama T
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 3 Pages: 224-32

    • DOI

      10.1111/cas.12873

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 前頭蓋底に浸潤した鼻・副鼻腔癌に対する拡大手術2009

    • Author(s)
      小川武則、小嶋郁穂、村田隆紀、阪本真弥、岸田佳太、高橋紀善、松下晴雄、荒川一弥、野村和弘、中目亜矢子、大越 明、東 賢二郎、石井 亮、嵯峨井 俊、神宮啓一、香取幸夫.
    • Journal Title

      JIBI INKOKA TEMBO

      Volume: 52 Issue: 6 Pages: 461-467

    • DOI

      10.11453/orltokyo.52.461

    • NAID

      130004546278

    • ISSN
      0386-9687, 1883-6429
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 口腔癌頸部リンパ節転移の節外進展診断における3 テスラblack-blood MR imaging法の有用性2018

    • Author(s)
      阪本真弥、小嶋郁穂、飯久保正弘、西岡貴志、笹野高嗣、伊藤康一、青木孝文、小川武則、森 士朗、小玉哲也
    • Organizer
      第59回日本歯科放射線学会学術大会
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Presentation] 口腔癌多発転移との鑑別を要したメトトレキサート関連リンパ増殖性疾患(MTX-LPD)の1例2018

    • Author(s)
      阪本真弥、小嶋郁穂、飯久保正弘、笹野高嗣、宮下 仁、纐纈 衆、川井 忠、高橋 哲、村田隆紀、外山由貴
    • Organizer
      第59回日本歯科放射線学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Diagnostic performance of MR imaging of three major salivary glands for sjögren’s syndrom.2017

    • Author(s)
      Kojima I, Sakamoto M, Iikubo M, Sasano T.
    • Organizer
      International Congress of Dento-Maxillo-Facial Radiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 3 テスラblack-blood MR imagingが口腔癌患者の頸部リンパ節転移診断に有用であった2症例2016

    • Author(s)
      小嶋郁穂、阪本真弥、飯久保正弘、小川武則、渡邉みか、大田英揮、村田隆紀、森 士朗、小玉哲也、笹野高嗣
    • Organizer
      第57回日本歯科放射線学会学術大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-06-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔癌の頸部リンパ節転移診断における3 テスラblack-blood MR imagingの有用性について2016

    • Author(s)
      阪本真弥、小嶋郁穂、飯久保正弘、近藤千裕、伊藤康一、青木孝文、小川武則、森 士朗、小玉哲也、笹野高嗣
    • Organizer
      第57回日本歯科放射線学会学術大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-06-18
    • Related Report
      2016 Research-status Report
  • [Presentation] リンパ節転移の新たな診断指標の提案2015

    • Author(s)
      八巻哲平,阪本真弥,森士朗,志賀清人,小玉哲也
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] シェーグレン症候群の耳下腺,顎 下腺,舌下腺のMRIに関する診断学的研究2015

    • Author(s)
      嶋田雄介、小嶋郁穂、阪本真弥、飯久保正弘、室井梓、菅原由美子、佐藤しづ子、笹野高嗣
    • Organizer
      第28回日本口腔診断学会学術大会
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Book] JOHNS「手術に必要な画像診断-口腔・咽頭編 下歯肉・下顎腫瘍切除術.2018

    • Author(s)
      石田英一、小川武則、小嶋郁穂、大越 明、石井 亮、川村善宜、石川智彦、橋本 光、香取幸夫.
    • Total Pages
      5
    • Publisher
      東京医学社
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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