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the examination of microRNA related with lymph node metastasis

Research Project

Project/Area Number 15K11294
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

TAMATANi Tetsuya  徳島大学, 病院, 講師 (30274236)

Co-Investigator(Kenkyū-buntansha) 宮本 洋二  徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (20200214)
高丸 菜都美  徳島大学, 大学院医歯薬学研究部(歯学域), 徳島大学専門研究員 (40513031)
永井 宏和  東北大学, 歯学研究科, 准教授 (50282190)
大江 剛  徳島大学, 病院, 講師 (60432762)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords口腔癌 / microRNA / 転移 / リンパ節転移
Outline of Final Research Achievements

We demonstrated the microRNA array analysis using patient blood who had total neck dissection before and after. The conditions were oral cancer patients who had without local recurrences after primary site operation, and occurred occult lymph node metastasis. The expression of miR-4664-5p, miR-6872-3p, miR-1290, miR-191-5p, miR-593-5p, miR-6778-5p, miR-4732-5p, miR-342-5p, miR-551b-5p miR-198, miR-4419b, miR-3619-3p, miR-23b-3p, and miR-107 might be related to lymph node metastases.

Academic Significance and Societal Importance of the Research Achievements

口腔癌は、直接口腔内を観察することで癌の存在、再発を診断できるが、口腔癌の頸部リンパ節転移の診断は画像検査によるところが大きい。そのため、転移をより早期に発見するためには、リンパ節転移を検出するバイオマーカーが必要である。しかし、腫瘍マーカーとして頻用されている血清SCC抗原値は、口腔癌に対する腫瘍マーカーとして特異性が低いと報告されているように、臨床的に有用な口腔癌の腫瘍マーカーは存在していない。しかし、われわれは、口腔癌リンパ節転移患者と健常者の血液中のmicroRNAを比較した結果、そのプロファイリングに大きな違いが見られることを明らかにし、マーカーになりえるmicroRNAを同定した。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Expression of CD44,CD44v9、ABCG2, CD24,Bmi-1 and ALDH1 in stage ⅠandⅡoral spuamous cell carcinoma and their association with clinicopathological factors2018

    • Author(s)
      TETSUYA TAMATANI, NATSUMI TAKAMARU, GO OHE, KAZUYA AKITA、TAKAYUKI NAKAGAWA、YOUJI MIYAMOTO
    • Journal Title

      ONCOLOGY LETTERS

      Volume: 16 Pages: 1133-1140

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of low crystalline carbonate apatite on proliferation and osteoblastic differentiation of human bone marrow cells2015

    • Author(s)
      Hirokazu Nagai, Masako Kobayashi-Fujioka, Kenji Fujisawa, Go Ohe, Natsumi Takamaru, Kanae Hara, Daisuke Uchida, Tetsuya Tamatani, Kunio Ishikawa, Youji Miyamoto
    • Journal Title

      J Mater Sci

      Volume: 26 Pages: 99-103

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] The clinicopathological roles of SOX2 and Oct4 expressions in stage I and II oral squamous cell carcinoma2018

    • Author(s)
      Tetsuya Tamatani, Natsumi Takamaru, Go Ohe, Takayuki Nakagawa, Naito Kurio, Keiko Kudo, Yoshiko Yamamura , Takamitsu Mano, Youji Miyamoto
    • Organizer
      AACR Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression of SOX2 and Oct4 in human oral squamous cell carcinoma and its relationship with clinical factors2017

    • Author(s)
      Tetsuya Tamatani, Natsumi Takamaru, Hirokazu Nagai, Kenji Fujisawa, Youji Miyamoto
    • Organizer
      AACR Annual Meeting 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 早期口腔扁平上皮癌患者におけるABCG2、ALDH1、Bmi-1、CD24およびCD44発現に関する検討2017

    • Author(s)
      玉谷哲也,髙丸菜都美,大江剛,藤澤健司、宮本洋二
    • Organizer
      第71回日本口腔科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] The clinicopathological roles of SOX2 in human oral squamous cell carcinoma2016

    • Author(s)
      Tetsuya Tamatani, Natsumi Takamaru, Go Ohe, Hirokazu Nagai, Youji Miyamoto
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Expression of ALDH1, Bmi-1 and CD24 in human oral squamous cell carcinoma and its relationship with clinical factors2016

    • Author(s)
      Tetsuya Tamatani, Natsumi Takamaru, Hirokazu Nagai, Kenji Fujisawa, Youji Miyamoto
    • Organizer
      AACR Annual Meeting 2016
    • Place of Presentation
      New Orleans、USA
    • Year and Date
      2016-04-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔扁平上皮癌におけるCD44,ABCG2およびALDH1の発現に関する検討2015

    • Author(s)
      玉谷哲也、高丸菜都美、大江剛、永井宏和、宮本洋二
    • Organizer
      第60回公益社団法人日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 口腔癌におけるBmi-1とCD24発現の臨床病理病理学的意義2015

    • Author(s)
      玉谷哲也、高丸菜都美、大江剛、永井宏和、宮本洋二
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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