| Project/Area Number |
15K11318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木賀 紀文 和歌山県立医科大学, 医学部, 助教 (20625397)
東條 格 和歌山県立医科大学, 医学部, 講師 (70405439)
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| Research Collaborator |
Takashi Nakanishi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 舌神経 / 舌神経修復術 / 断端神経腫 / 神経再生 / 神経再生誘導管 / 神経損傷 / 神経障害性疼痛 / 神経性疼痛 / 神経断端腫 |
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| Outline of Final Research Achievements |
The purpose of this study is to identify the factors associated with after the microneurosurgery removing traumatic neuroma in lingual nerve. The sample population was 70 patients who underwent microneurosurgery removing traumatic neuroma in lingual nerve. The recovery ratio of lingual nerve sensory was not significantly different in the patients who underwent the microneurosurgery less than 6 months after injury (early cases) than the other patient (late cases). However, the abundance ratio of Schwann cells in the 30 traumatic neuromas was significantly decreased in the late cases compared with early cases. Further, the gene expression changes were analyzed in traumatic neuromas using microarray analysis, and the candidate genes associated with lingual nerve repair was indicated using pathway analysis. The five proteins out of the proteins translated from the 20 genes were more expressed in the traumatic neuroma from the patients whose sensory functions were remarkable recovered.
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