| Project/Area Number |
15K11389
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Periodontology
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
Tsuyoshi Fujita 広島大学, 医歯薬保健学研究科(歯), 准教授 (80379883)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
加治屋 幹人 広島大学, 医歯薬保健学研究科(歯), 助教 (00633041)
松田 真司 広島大学, 病院(歯), 病院助教 (30611321)
|
|---|
| Research Collaborator |
MIYAGAWA TSUYOSHI
IMAI HARUKA
YOSHIMOTO TETSUYA
AKUTAGAWA KEIICHI
TAKEMURA TASUKU
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 歯周病 / 糖尿病 / Porphyromonas gulae / サイトカイン / HMGB1 / RAGE / 血糖値 / マウス / 歯周炎 / グリチルリチン / 血清アミロイド A / CRP / SAA / IL-6 |
|---|
| Outline of Final Research Achievements |
Periodontital disease is deeply associated with diabetes mellitus (DM) in both directions. Glycyrrhizin has an anti-inflammatory effect by inhibiting HMGB1. Regulation of periodontal inflammation in DM patients may contribute to control both diseases. In this study, we examined the effects of oral treatment with glycyrrhizin on the inflammation and serum glucose levels using ligature-induced inflammation with P. gulae-infection on high fat diet-induced diabetic mice. Topical treatment of glycyrrhizin down-regulated gingival inflammation and the increased glucose levels in serum induced by the combination of ligature and P. gulae infection in diabetic mice. In conclusion, glycyrrhizin down-regulates inflammatory responses in gingival tissue and improve glucose levels by suppressing the circulating cytokine levels.
|
