Clofibrate produce IL-1Ra and inhibit the experimental periodontitis
| Project/Area Number |
15K11402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉成 伸夫 松本歯科大学, 歯学部, 教授 (20231699)
小出 雅則 松本歯科大学, 総合歯科医学研究所, 講師 (10367617)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | クロフィブラート / IL-1Ra / IL-1 / 実験的歯周炎 / 高脂血症治療薬 / インターロイキンレセプターアンタゴニスト / 歯周治療 / インターロイキン１ / インターロイキン１レセプターアンタゴニスト |
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| Outline of Final Research Achievements |
Inflammatory cytokines are deeply involved in the onset and progression of periodontal disease. It has been reported that hyperlipidemic drug of clofibrate produce high levels of IL-1Ra from brain macrophage, therefore we investigated the IL-1Ra production from mouse macrophage stimulated with lipopolysaccharide of periodontal pathogenic bacteria. Expression of IL-1β and TNF-α from mouse macrophage was significantly increased. Expression of IL-1Ra, IL-6, IL-1α and IL-1 receptor (IL-1R1) was same levels as that of the control, although the expression trend of SOCS3 was somewhat increased.
These findings suggested that clofibrate alone may act to increase a periodontal tissues inflammation.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case-control study.2018
Author(s)
Kobayashi T, Kido JI, Ishihara Y, Omori K, Ito S, Matsuura T, Bando T, Wada J, Murasawa A, Nakazono K, Mitani A, Takashiba S, Nagata T, Yoshie H.
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Journal Title
J Periodontol
Volume: 89(3)
Issue: 3
Pages: 315-324
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice2017
Author(s)
Ishida N, Ishihara Y, Ishida K, Tada H, Funaki-Kato Y, Hagiwara M, Ferdous T, Abdullah M, Mitani A, Michikawa M, Matsushita K.
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Journal Title
NPJ Aging Mech. Dis.
Volume: 3
Issue: 1
Pages: 15-15
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression.2015
Author(s)
Goto H, Ishihara Y, Kikuchi T, Izawa A, Ozeki N, Kamiya Y, Ozawa Y, Mizutani H, Yamamoto G, Mogi M, Nakata K, Maeda H, Noguchi T, Mitani A.
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Journal Title
PLoS One.
Volume: 10
Issue: 10
Pages: e0140942-e0140942
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Adhesion Properties of Human Oral Epithelial-Derived Cells to Zirconia.2015
Author(s)
Okabe E, Ishihara Y, Kikuchi T, Izawa A, Kobayashi S, Goto H, Kamiya Y, Sasaki K, Ban S, Noguchi T, Kawai T, Mitani A.
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Journal Title
Clin Implant Dent Relat Res.
Volume: 10
Issue: 5
Pages: 906-916
DOI
Related Report
Peer Reviewed
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