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Clofibrate produce IL-1Ra and inhibit the experimental periodontitis

Research Project

Project/Area Number 15K11402
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontology
Research InstitutionMatsumoto Dental University

Principal Investigator

Ishihara Yuichi  松本歯科大学, 歯学部, 教授 (50261011)

Co-Investigator(Kenkyū-buntansha) 吉成 伸夫  松本歯科大学, 歯学部, 教授 (20231699)
小出 雅則  松本歯科大学, 総合歯科医学研究所, 講師 (10367617)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsクロフィブラート / IL-1Ra / IL-1 / 実験的歯周炎 / 高脂血症治療薬 / インターロイキンレセプターアンタゴニスト / 歯周治療 / インターロイキン1 / インターロイキン1レセプターアンタゴニスト
Outline of Final Research Achievements

Inflammatory cytokines are deeply involved in the onset and progression of periodontal disease. It has been reported that hyperlipidemic drug of clofibrate produce high levels of IL-1Ra from brain macrophage, therefore we investigated the IL-1Ra production from mouse macrophage stimulated with lipopolysaccharide of periodontal pathogenic bacteria. Expression of IL-1β and TNF-α from mouse macrophage was significantly increased. Expression of IL-1Ra, IL-6, IL-1α and IL-1 receptor (IL-1R1) was same levels as that of the control, although the expression trend of SOCS3 was somewhat increased.
These findings suggested that clofibrate alone may act to increase a periodontal tissues inflammation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case-control study.2018

    • Author(s)
      Kobayashi T, Kido JI, Ishihara Y, Omori K, Ito S, Matsuura T, Bando T, Wada J, Murasawa A, Nakazono K, Mitani A, Takashiba S, Nagata T, Yoshie H.
    • Journal Title

      J Periodontol

      Volume: 89(3) Issue: 3 Pages: 315-324

    • DOI

      10.1002/jper.17-0412

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice2017

    • Author(s)
      Ishida N, Ishihara Y, Ishida K, Tada H, Funaki-Kato Y, Hagiwara M, Ferdous T, Abdullah M, Mitani A, Michikawa M, Matsushita K.
    • Journal Title

      NPJ Aging Mech. Dis.

      Volume: 3 Issue: 1 Pages: 15-15

    • DOI

      10.1038/s41514-017-0015-x

    • NAID

      120006576159

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bone Formation is coupled to resorption via suppression of sclerostin expression by osteoclasts.2017

    • Author(s)
      Koide M, Kobayashi Y, Yamashita T, Uehara S, Nakamura M, Hiraoka BY, Ozaki Y, Iimura T, Yasuda H, Takahashi N and Udagawa N
    • Journal Title

      J Bone Mineral Res

      Volume: 32 Issue: 10 Pages: 2074-2086

    • DOI

      10.1002/jbmr.3175

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Treatment of OPG-deficient mice with WP9QY, a RANKL-binding peptide, recovers alveolar bone loss by suppressing osteoclastogenesis and enhancing osteoblastogenesis2017

    • Author(s)
      Ozaki Yuki、Koide Masanori、Furuya Yuriko、Ninomiya Tadashi、Yasuda Hisataka、Nakamura Midori、Kobayashi Yasuhiro、Takahashi Naoyuki、Yoshinari Nobuo、Udagawa Nobuyuki
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 9 Pages: e0184904-e0184904

    • DOI

      10.1371/journal.pone.0184904

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 骨はダイナミックに躍動している2016

    • Author(s)
      宇田川信之,小出雅則,溝口利英,中村美どり,下平滋隆,田口明
    • Journal Title

      日本顎咬合学会誌

      Volume: 36 Pages: 161-170

    • NAID

      130007685100

    • Related Report
      2016 Research-status Report
  • [Journal Article] Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression.2015

    • Author(s)
      Goto H, Ishihara Y, Kikuchi T, Izawa A, Ozeki N, Kamiya Y, Ozawa Y, Mizutani H, Yamamoto G, Mogi M, Nakata K, Maeda H, Noguchi T, Mitani A.
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 10 Pages: e0140942-e0140942

    • DOI

      10.1371/journal.pone.0140942

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Adhesion Properties of Human Oral Epithelial-Derived Cells to Zirconia.2015

    • Author(s)
      Okabe E, Ishihara Y, Kikuchi T, Izawa A, Kobayashi S, Goto H, Kamiya Y, Sasaki K, Ban S, Noguchi T, Kawai T, Mitani A.
    • Journal Title

      Clin Implant Dent Relat Res.

      Volume: 10 Issue: 5 Pages: 906-916

    • DOI

      10.1111/cid.12369

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] IL-1Ra欠損マウスでは破骨細胞形成と炎症性骨吸収が亢進する2017

    • Author(s)
      石原裕一,小出雅則,吉成伸夫
    • Organizer
      第2回日本骨免疫学会ウインターセミナー
    • Place of Presentation
      ホテルマロウド軽井沢(長野)
    • Year and Date
      2017-01-27
    • Related Report
      2016 Research-status Report
  • [Presentation] IL-1Ra欠損マウスでの破骨細胞形成と炎症性骨吸収が亢進する2017

    • Author(s)
      石原裕一,小出雅則,吉成伸夫
    • Organizer
      第2回日本骨免疫学会ウインターセミナ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 歯周組織におけるIL-1Raの役割と治療薬への可能性2017

    • Author(s)
      石原裕一
    • Organizer
      60回春季日本歯周病学会学術大会 学会学術賞記念講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] W9ペプチド投与によるOPG遺伝子欠損マウスの歯槽骨喪失の改善効果2017

    • Author(s)
      尾崎友輝,小出雅則,古屋優里子,二宮 禎,保田尚孝,中村美どり,吉成伸夫,高橋直之,宇田川信之.
    • Organizer
      第35回日本骨代謝学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] W9ペプチド投与はOPG遺伝子欠損マウスの歯槽骨喪失を改善する2017

    • Author(s)
      尾崎友輝, 小出雅則, 二宮 禎, 中村美どり, 吉成伸夫, 高橋直之, 宇田川信之.
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The Effect of Serum Amyloid A for Endothelial Cell2016

    • Author(s)
      Yoshinari,N., Takahashi K., Kaise K., Saleem M., Ozaki Y., Nakamura S., Kubokawa K., Ishihara Y.
    • Organizer
      94th General session of the IADR
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Research-status Report
  • [Presentation] W9ペプチドはOPG遺伝子欠損マウスの歯槽骨吸収を改善する2016

    • Author(s)
      尾﨑友輝,小出雅則,宇田川信之,吉成伸夫
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      鹿児島県民交流センター(鹿児島)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 骨吸収はsclerostinの発現低下を介して骨形成を促進する2016

    • Author(s)
      小出雅則、尾崎友輝、吉成伸夫、石原裕一、宇田川信之
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      鹿児島県民交流センター(鹿児島)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Adhesion properties of human oral epithelial-derived cells to zirconia2015

    • Author(s)
      Okabe E, Ishihara Y, Kikuchi T, Izawa A, Kobayashi S, Goto H, Kamiya Y, Ban S, Noguchi T, Kawai T and Mitani A
    • Organizer
      第63回国際歯科研究会日本部会総会・学術総会
    • Place of Presentation
      福岡 福岡国際会議場
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] ジルコニアに対するヒト口腔由来上皮細胞の付着特性2015

    • Author(s)
      郎,石原裕一,菊池 毅,伊澤有郎,小林周一郎,後藤久嗣,神谷洋介,伴 清治,野口俊英,河合逹志,三谷章雄
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      浜松 アクトシティ浜松
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Book] 第2章 5歯周病モデル動物におけるRANKL療法,ファーマナビゲーター 抗RANKL抗体編2016

    • Author(s)
      宇田川信之,小出雅則,中村美どり
    • Total Pages
      8
    • Publisher
      メディカルレビュー社
    • Related Report
      2016 Research-status Report
  • [Book] THE BONE 骨リモデリングの制御機構,第9章 スクレロスチンによる骨リモデリング制御2016

    • Author(s)
      小出雅則,宇田川信之
    • Total Pages
      4
    • Publisher
      メディカルレビュー社
    • Related Report
      2016 Research-status Report
  • [Book] THE BONE 骨リモデリングの制御機構,第10章 オステオプロテゲリンによる骨リモデリング制御2016

    • Author(s)
      中村美どり,中道裕子,小出雅則,宇田川信之
    • Total Pages
      5
    • Publisher
      メディカルレビュー社
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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