| Project/Area Number |
15K11402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉成 伸夫 松本歯科大学, 歯学部, 教授 (20231699)
小出 雅則 松本歯科大学, 総合歯科医学研究所, 講師 (10367617)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | クロフィブラート / IL-1Ra / IL-1 / 実験的歯周炎 / 高脂血症治療薬 / インターロイキンレセプターアンタゴニスト / 歯周治療 / インターロイキン１ / インターロイキン１レセプターアンタゴニスト |
|---|
| Outline of Final Research Achievements |
Inflammatory cytokines are deeply involved in the onset and progression of periodontal disease. It has been reported that hyperlipidemic drug of clofibrate produce high levels of IL-1Ra from brain macrophage, therefore we investigated the IL-1Ra production from mouse macrophage stimulated with lipopolysaccharide of periodontal pathogenic bacteria. Expression of IL-1β and TNF-α from mouse macrophage was significantly increased. Expression of IL-1Ra, IL-6, IL-1α and IL-1 receptor (IL-1R1) was same levels as that of the control, although the expression trend of SOCS3 was somewhat increased.
These findings suggested that clofibrate alone may act to increase a periodontal tissues inflammation.
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