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Proposal to disaster medicine from a viewpoint of oral dryness and taste disorder on Great East Japan Earthquake victims

Research Project

Project/Area Number 15K11407
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionTohoku University

Principal Investigator

Satoh Shizuko  東北大学, 歯学研究科, 助教 (60225274)

Co-Investigator(Kenkyū-buntansha) 笹野 高嗣  東北大学, 歯学研究科, 名誉教授 (10125560)
庄司 憲明  東北大学, 大学病院, 講師 (70250800)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords震災ストレス / 東日本大震災 / 口腔乾燥 / 総唾液分泌量 / 小唾液腺分泌量 / 味覚障害 / 高齢者
Outline of Final Research Achievements

We conducted epidemiological survey about oral dryness and taste disorder on victims of Great East Japan Earthquake. As for oral dryness, whole salivation volume and minor gland secretion were measured. As for taste disorder, recognition thresholds of five basic tastes were respectively measured. Mental stress caused by Great East Japan Earthquake was evaluated by POMS (Profile of Mood States) on each victim.
This study showed that the greater mental stress decreased whole salivation and/or minor salivary gland secretion, and rose the recognition thresholds of five basic tastes. Our findings suggested that there was association between the mental stress of Great East Japan Earthquake, and oral dryness and/or taste disorder.

Academic Significance and Societal Importance of the Research Achievements

東北大学病院には、東日本大震災後に口腔乾燥および味覚障害に起因する全身状態の悪化を訴える高齢者が訪れている。しかしながら、震災ストレスとの関連は不明だった。震災後長期ストレスと口腔乾燥および味覚障害発症の関連があることを明らかにした本研究成果は、震災後の高齢者に多発する「全身状態の悪化」を予防・治療ための新たな戦略として、災害医療への提言につながる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (34 results)

All 2018 2017 2016 2015

All Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 11 results,  Acknowledgement Compliant: 1 results) Presentation (22 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Effects and mechanisms of tastants on gustatory-salivary reflex in human minor salivary glands.2018

    • Author(s)
      Satoh-Kuriwada S, Shoji N, Miyake H, Watanabe C, Sasano T.
    • Journal Title

      BioMed Research International.

      Volume: Article ID 3847075 Pages: 1-12

    • DOI

      10.1155/2018/3847075

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in Taste Perception and Spicy Preference: A Thai-Japanese Cross-cultural Study.2018

    • Author(s)
      Trachootham D, Satoh-Kuriwada S, Lam-ubol A, Promkam C, Chotechuang N, Sasano T, Shoji N.
    • Journal Title

      Chemical Senses.

      Volume: 43 Issue: 1 Pages: 65-74

    • DOI

      10.1093/chemse/bjx071

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects and mechanisms of tastants on the gustatory-salivary reflex in human minor salivary glands.2018

    • Author(s)
      Satoh-Kuriwada S, Shoji N, Miyake H, Watanabe C, Sasano T.
    • Journal Title

      BioMedical Research International

      Volume: Article ID 3847075 Pages: 1-18

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in taste perception and spicy preference: A Thai-Japanese cross-culture study.2018

    • Author(s)
      Ttachootham D, Satoh-Kuriwada S, Lam-ubol A,Promkam C, Chotechuang N, Sasano T, Shoji N
    • Journal Title

      Chemical Senses

      Volume: 43 Pages: 65-74

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diagnostic performance of MR Imaging of three major salivary glands for Sjögren’s syndrome.2017

    • Author(s)
      Kojima I, Sakamoto M, Iikubo M, Kumamoto H, Muroi A, Sugawara Y, Satoh-Kuriwada S, Sasano T
    • Journal Title

      Oral Disease

      Volume: 23 Pages: 84-90

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 味覚唾液反射を応用した新たな口腔乾燥治療2015

    • Author(s)
      佐藤しづ子、笹野高嗣
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 135 Pages: 783-787

    • NAID

      130005071783

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ドライマウス治療に味覚刺激を利用する2015

    • Author(s)
      佐藤しづ子、笹野高嗣
    • Journal Title

      日本薬理学雑誌

      Volume: 145 Pages: 288-292

    • NAID

      130005075726

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 味覚診断に関する最近の話題 -うま味検査法についてー2015

    • Author(s)
      笹野高嗣、佐藤しづ子
    • Journal Title

      日本薬理学雑誌

      Volume: 145 Pages: 330-330

    • NAID

      130005075734

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The important role of umami taste in oral and overall health2015

    • Author(s)
      Takashi Sasano, Shizuko Satoh-Kuriwada, Noriaki Shoji
    • Journal Title

      Flavour

      Volume: 4 Issue: 1 Pages: 10-10

    • DOI

      10.1186/2044-7248-4-10

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of umami-taste-related genesin the tongue: a pilot study for genetic taste diagnosis2015

    • Author(s)
      Shoji N, Kaneta N, Satoh-Kuriwada S, Tsuchiya M, Hashimoto N, Uneyama H, Kawai M, Sasano T
    • Journal Title

      Oral Dis.

      Volume: 21 Issue: 6 Pages: 801-806

    • DOI

      10.1111/odi.12350

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome.2015

    • Author(s)
      Shinoda M, Takeda M, Honda K, Maruno M, Katagiri A, Satoh-Kuriwada S, Shoji N, Tsuchiya M, Iwata K
    • Journal Title

      Pain

      Volume: 156 Issue: 12 Pages: 2528-2537

    • DOI

      10.1097/j.pain.0000000000000322

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ヒト小唾液腺の味覚ー唾液反射における”うま味”の有用性について2018

    • Author(s)
      佐藤しづ子、庄司憲明、笹野高嗣
    • Organizer
      日本味と匂学会 第52回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 東北メディカル・メガバンクのリファレンスパネルを利用した苦味受容体の個人差と味嗜好性との関連2018

    • Author(s)
      八巻美智子、三森隆弘、小野彰、鈴木洋一、長崎正朗、山本雅之、佐藤しづ子、庄司憲明、齋藤弘貴、磯野邦夫、後藤知子、白川仁、駒井三千夫
    • Organizer
      日本味と匂学会 第52回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乳がん薬物療法による味覚障害について2018

    • Author(s)
      傳田祐也、庄司憲明、岡村卓穂、新倉直樹、徳田裕、佐藤しづ子、太田嘉英、笹野高嗣
    • Organizer
      日本味と匂学会 第52回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 味覚障害を併発した口腔扁平苔癬の2例2018

    • Author(s)
      佐藤しづ子、菅原由美子、笹野高嗣、庄司憲明
    • Organizer
      第28回日本口腔内科学会 第31回日本口腔診断学会 合同学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] うま味研究の最前線ー脳認知の解析及び口腔保健への応用:うま味によるヒト小唾液腺における味覚ー唾液反射について2018

    • Author(s)
      佐藤しづ子
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 味覚障害の新規指標の解析2018

    • Author(s)
      鈴木綾、後藤知子、佐藤しづ子、笹野高嗣、島崎伸子、白川仁、駒井三千夫
    • Organizer
      日本味と匂学会 第52回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Smoking can affect bitter, sweet, umami taste receptors gene expression.2017

    • Author(s)
      Shizuko Satoh-Kuriwada, Noriaki Shoji, Takashi Sasano
    • Organizer
      The 95th International Association for Dental Research
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2017-03-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高齢者の味覚異常感は栄養摂取に影響を与える2017

    • Author(s)
      佐藤しづ子、庄司憲明、笹野高嗣
    • Organizer
      第55回日本口腔科学会北日本地方部会・第43回日本口腔外科学会北日本支部学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 味覚障害患者の栄養状態ー味覚正常者との栄養状態・栄養素摂取量の比較ー2017

    • Author(s)
      佐藤しづ子、庄司憲明、日比野智香子笹野高嗣
    • Organizer
      第27回日本口腔内科学会・第30回日本口腔診断学会合同学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 味覚障害における医科歯科連携の重要性ー口腔内味覚受容器障害と嗅覚障害に対する具体例についてー2017

    • Author(s)
      佐藤しづ子、庄司憲明、渡邊暁子、河合美佐子、畝山寿之、笹野高嗣
    • Organizer
      日本味と匂学会第51回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 味覚障害治療における歯科耳鼻科連携の重要性2016

    • Author(s)
      佐藤しづ子、庄司憲明、笹野高
    • Organizer
      第26会日本口腔内科学会第29回日本口腔診断学会 合同学術大会
    • Place of Presentation
      山陽新聞本社ビル、岡山
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 高齢者における味覚異常感は食と栄養摂取に影響を与える2016

    • Author(s)
      佐藤しづ子、日比野智香子
    • Organizer
      第63回日本栄養改善学会学術総会
    • Place of Presentation
      リンクステーション青森
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Development of an umami-taste sensitivity test and its clinical use. -Patients with umami specific taste disorder and their loss of appetite-.2016

    • Author(s)
      Shizuko Satoh-Kuriwada, Noriaki Shoji, Misako Kawai, Hisayuki Uneyama, Takashi Sasan
    • Organizer
      The 17th International Symposium on Olfaction and Tast
    • Place of Presentation
      PACIFICO Yokohama
    • Year and Date
      2016-06-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The importance of nutrition support for the taste disorder -Nutrient conditions of the patients with taste disorder -.2016

    • Author(s)
      Chikako Hibino, Shizuko Satoh-Kuriwada, Takashi Sasano
    • Organizer
      The 17th International Symposium on Olfaction and Tast
    • Place of Presentation
      PACIFICO Yokohama
    • Year and Date
      2016-06-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Risk of malnutrition in the elderly with umami taste sensitivity loss revealed by the newly developed umami taste sensitivity test2015

    • Author(s)
      Satoh-Kuriwada S, Kawai M, Shoji N, Uneyama H, Sasano T.
    • Organizer
      ILSI Japan 第7回「栄養とエイジング」国際会議
    • Place of Presentation
      東京
    • Year and Date
      2015-09-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ”うま味”検査によって判明した悪性貧血の2例2015

    • Author(s)
      佐藤しづ子、庄司憲明、河合美佐子、畝山寿之、笹野高嗣
    • Organizer
      日本味と匂学会 第49回大会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 味覚障害患者に対する栄養管理サポートシステムの重要性について 第1報 味覚障害患者の栄養特性2015

    • Author(s)
      日比野智香子、佐藤しづ子、笹野高嗣
    • Organizer
      日本味と匂学会 第49回大会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 味覚受容体遺伝子発現を指標とした客観的「うま味」検査法の開発2015

    • Author(s)
      庄司憲明、金田直人、佐藤しづ子、土谷昌広、橋本直也、笹野高嗣
    • Organizer
      第25回日本口腔内科学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 味覚-唾液反射による小唾液腺唾液の分泌量促進およびIgA増加について2015

    • Author(s)
      佐藤しづ子、庄司憲明、笹野高嗣
    • Organizer
      第28回日本口腔診断学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
  • [Presentation] ”うま味”検査によって判明した悪性貧血の2例2015

    • Author(s)
      佐藤しづ子、庄司憲明、河合美佐子、畝山寿之、笹野高嗣
    • Organizer
      第28回日本口腔診断学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 味覚障害患者に対する栄養管理サポートシステムの重要性について 第1報 味覚障害患者の栄養特性2015

    • Author(s)
      日比野智香子、佐藤しづ子、笹野高嗣
    • Organizer
      第28回日本口腔診断学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
  • [Presentation] シェーグレン症候群の耳下腺、顎下腺、舌下腺のMRIに関する診断学的研究 -MRI信号強度不均一とMR sialography 点状高信号域の診断精度についてー2015

    • Author(s)
      嶋田雄介、小嶋郁穂、阪本真弥、飯久保正弘、室井梓、菅原由美子、佐藤しづ子、笹野高嗣
    • Organizer
      第28回日本口腔診断学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
  • [Book] 食物と健康の科学シリーズ だしの科学 的場輝佳、外内尚人 編2017

    • Author(s)
      佐藤しづ子、笹野高嗣
    • Total Pages
      193
    • Publisher
      朝倉書店
    • ISBN
      9784254435542
    • Related Report
      2017 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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