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Role of apelin on mechanisms to improve state of periodontitis by physical activity and its application to preventive dentistry

Research Project

Project/Area Number 15K11423
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionKyushu Dental College

Principal Investigator

Akifusa Sumio  九州歯科大学, 歯学部, 教授 (40295861)

Co-Investigator(Kenkyū-buntansha) 有吉 渉  九州歯科大学, 歯学部, 准教授 (40405551)
臼井 通彦  九州歯科大学, 歯学部, 准教授 (10453630)
沖永 敏則  九州歯科大学, 歯学部, 講師 (60582773)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords身体活動 / apelin / 高齢者 / 栄養 / 菌叢解析 / 口腔ケア / 歯周疾患 / 最大呼気量 / 血管流路 / サイトカイン
Outline of Final Research Achievements

We investigated relationship between physical activity and oral health status in older adults by follow-up survey. The cohort of older adults with dysphagia at baseline deteriorated physical activity and nutritional status at 1 years later, comparing with the cohort having normal swallowing function. Mortality risk of older adults with > 9 remained tooth and dysphagia was 2.89-fold higher than that of older adults > 10 remained tooth and with normal swallowing function. Next we elucidated the peak expiratory flow (PEF), having closing relation with physical activity, in older adults who were intervened with oral care with tongue cleaning. The PEFs of older adults intervened by oral care with tongue cleaning was significantly higher than of those without tongue cleaning. Unfortunately, we could get no significant data on relationship between amounts of blood apelin and PEF.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (22 results)

All 2017 2016 2015

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Acknowledgement Compliant: 2 results,  Open Access: 4 results) Presentation (7 results) Book (2 results)

  • [Journal Article] Tooth loss, swallowing dysfunction and mortality in Japanese older adults receiving home care services2017

    • Author(s)
      Furuta, M., Takeuchi, K., Adachi, M., Kinoshita, T., Eshima, N., Akifusa, S., Kikutani, T., Yamashita, Y.
    • Journal Title

      Geriatrics & Gerontology International

      Volume: - Issue: 6 Pages: 873-880

    • DOI

      10.1111/ggi.13271

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Swallowing disorders and 1-year functional decline in community-dwelling older adults receiving home care.2017

    • Author(s)
      Takeuchi K, Furuta M, Okabe Y, Suma S, Takeshita T, Akifusa S, Adachi M, Kinoshita T, Kikutani T, Yamashita Y.
    • Journal Title

      J Oral Rehabil.

      Volume: 44 Issue: 12 Pages: 982-987

    • DOI

      10.1111/joor.12577

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reliability and Validity of the MD Anderson Dysphagia Inventory Among Japanese Patients2017

    • Author(s)
      Matsuda Yuhei、Kanazawa Manabu、Komagamine Yuriko、Yamashiro Masashi、Akifusa Sumio、Minakuchi Shunsuke
    • Journal Title

      Dysphagia

      Volume: 33 Issue: 1 Pages: 123-132

    • DOI

      10.1007/s00455-017-9842-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validity and reliability of the oral health-related caregiver burden index2017

    • Author(s)
      Matsuda Yuhei、Izumi Maya、Nakamichi Atsuko、Isobe Ayaka、Akifusa Sumio
    • Journal Title

      Gerodontology

      Volume: 34 Issue: 3 Pages: 390-397

    • DOI

      10.1111/ger.12281

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High molecular weight hyaluronic acid regulates MMP13 expression in chondrocytes via DUSP10/MKP52017

    • Author(s)
      Furuta J, Ariyoshi W, Okinaga T, Takeuchi J, Mitsugi S, Tominaga K, Nishihara T.
    • Journal Title

      J Orthop Res

      Volume: 35 Issue: 12 Pages: 331-339

    • DOI

      10.1002/jcp.25809

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploration of bacterial species associated with the salivary microbiome of individuals with a low susceptibility to dental caries2017

    • Author(s)
      Yasunaga H, Takeshita T, Shibata Y, Furuta M, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Takahashi I, Yamashita Y
    • Journal Title

      Clin Oral Investig

      Volume: 印刷中 Issue: 8 Pages: 1-1

    • DOI

      10.1007/s00784-016-2035-5

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stimulated salivary flow rate and oral health status2017

    • Author(s)
      Shimazaki Y, Fu B, Yonemoto K, Akifusa S, Shibata Y, Takeshita T, Ninomiya T, Kiyohara Y, Yamashita Y
    • Journal Title

      Journal of Oral Science

      Volume: 59 Issue: 1 Pages: 55-62

    • DOI

      10.2334/josnusd.16-0372

    • NAID

      130005519818

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study.2016

    • Author(s)
      Takeshita T, Kageyama S, Furuta M, Tsuboi H, Takeuchi K, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y.
    • Journal Title

      Science Reorts

      Volume: 6 Issue: 1 Pages: 1-11

    • DOI

      10.1038/srep22164

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Swallowing Function and Nutritional Status in Japanese Elderly People Receiving Home-care Services: A 1-year Longitudinal Study.2016

    • Author(s)
      Okabe Y, Furuta M, Akifusa S, Takeuchi K, Adachi M, Kinoshita T, Kikutani T, Nakamura S, Yamashita Y
    • Journal Title

      J Nutr Health Aging

      Volume: 20 Issue: 7 Pages: 697-697

    • DOI

      10.1007/s12603-015-0645-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Oral Care with Tongue Cleaning on Coughing Ability in Geriatric Care Facilities: A Randomized Controlled Trial.2016

    • Author(s)
      Izumi M, Takeuchi K, Ganaha S, Akifusa S, Yamashita Y
    • Journal Title

      J Oral Rehabil

      Volume: 43 Issue: 12 Pages: 953-953

    • DOI

      10.1111/joor.12451

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship Between Self-Rated Masticatory Ability and Independent Life in Community-Dwelling Older Adults.2016

    • Author(s)
      Hironaka M, Kayama Y, Misaka Y, Akifusa S
    • Journal Title

      Gerontology & Geriatric Medicine

      Volume: 2 Pages: 1-1

    • DOI

      10.1177/2333721415603193

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serum antibody to Porphyromonas gingivalis and periodontitis progression: The Hisayama Study.2015

    • Author(s)
      Takeuchi K, Furuta M, Takeshita T, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y.
    • Journal Title

      Journal of Clinical Periodontology

      Volume: 14 Issue: 8 Pages: 719-725

    • DOI

      10.1111/jcpe.12431

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factors for reduced salivary flow rate in a Japanese population: the Hisayama Study2015

    • Author(s)
      Takeuchi K, Furuta M, Takeshita T, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y
    • Journal Title

      Biomedical Research International

      Volume: 2015 Pages: 381821-381821

    • DOI

      10.1155/2015/381821

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 地域における幼児保護者および高齢者への歯科保健指導・相談の満足度(第2報)2016

    • Author(s)
      三阪 美恵、中道 敦子、 高橋 由希子、 泉 繭依、 有川 英里、 黒木 愛由、 磯部 彩香、 川野 亜希、 渕上 祐子、 引地 尚子、 久保田 浩三、 秋房 住郎
    • Organizer
      九州歯科学会
    • Place of Presentation
      九州歯科大学
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 嚥下機能低下による在宅療養高齢者の日常生活動作自立度低下リスクの縦断的検証2016

    • Author(s)
      竹内 研時、古田 美智子、 岡部 優花、 秋房 住郎、 足立 宗久、 木下 俊則、 菊谷 武、 山下 喜久
    • Organizer
      日本口腔衛生学会
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 80歳地域住民における糖尿病と歯周病の生命予後への影響2016

    • Author(s)
      田上 綾香、園木 一男、 粟野 秀慈、 高田 豊、 秋房 住郎、 福原 正代、 角田 聡子、 邵 仁浩、 岩崎 正則、 安細 敏弘
    • Organizer
      日本歯周病学会
    • Place of Presentation
      かごしま県民交流センター
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 80歳地域住民における糖尿病の生命予後への影響2016

    • Author(s)
      園木 一男、秋房 住郎、高田 豊 福原 正代、邵 仁浩、安細 敏弘、粟野 秀慈
    • Organizer
      日本糖尿病学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 在宅療養要介護高齢者の口腔機能と生活活動動作に関する縦断的検討2015

    • Author(s)
      古田 美智子, 秋房 住郎, 岡部 優花, 足立 宗久, 木下 俊則, 竹内 研時, 中村 誠司, 菊谷 武, 山下 喜久
    • Organizer
      日本口腔衛生学会
    • Place of Presentation
      つくば市
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 血清抗体価による歯周疾患重症化リスクの縦断的検証 久山町研究2015

    • Author(s)
      竹内 研時, 古田 美智子, 竹下 徹, 柴田 幸江, 嶋崎 義浩, 秋房 住郎, 山下 喜久
    • Organizer
      日本口腔衛生学会
    • Place of Presentation
      つくば市
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 在宅要介護高齢者における低栄養と口腔機能に関する縦断研究2015

    • Author(s)
      岡部 優花, 古田 美智子, 秋房 住郎, 足立 宗久, 木下 俊則, 菊谷 武, 竹内 研時, 中村 誠司, 山下 喜久
    • Organizer
      日本口腔衛生学会
    • Place of Presentation
      つくば市
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
  • [Book] 地域包括ケアシステムで活かせる! 在宅・施設で行う口腔ケアに必要な介護技術2017

    • Author(s)
      秋房住郎、泉繭依、生野繁子、我那覇生純、小林さおり、中道敦子、藤井 航
    • Total Pages
      123
    • Publisher
      永末書店
    • ISBN
      9784816013317
    • Related Report
      2017 Annual Research Report
  • [Book] すぐひける、現場で役立つ歯科衛生士のためのポケット版 最新歯科用語辞典2016

    • Author(s)
      栢豪洋・升井一朗・石川隆義・玄景華・小菅直樹・雫石聰・濵元一美・本間和代・鱒見進一
    • Total Pages
      374
    • Publisher
      クインテッセンス株式会社
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-12-27  

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