Roles of Jixueteng in therapeutic agents for periodontitis
| Project/Area Number |
15K11434
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
Toshizo Toyama 神奈川歯科大学, 歯学部, 特任講師 (60638906)
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| Co-Investigator(Kenkyū-buntansha) |
浜田 信城 神奈川歯科大学, 大学院歯学研究科, 教授 (20247315)
吉野 文彦 神奈川歯科大学, 大学院歯学研究科, 准教授 (20308307)
高橋 俊介 神奈川歯科大学, 大学院歯学研究科, 教授 (60206810)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 鶏血藤 / 歯周炎 / 殺菌作用 / 抗酸化作用 / 歯槽骨吸収抑制 / 細菌 / 歯周病 / 活性酸素 / 歯肉微小循環 / 生薬 |
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| Outline of Final Research Achievements |
We investigated the preventive effects of Jixueteng, Chinese herbal medicine, on periodontitis using mouse experimental periodontitis model induced by P. gingivalis infection. Jixueteng possessed bactericidal effect against P. gingivalis in a dose-dependent manner. In P. gingivalis-infected mice, significant alveolar bone resorption and remarkable reduction in gingival vascular function via oxidative stress were observed. Morphological degeneration of vessels was also observed in the number of vascular networks abnormality of the vascular lumen was caused by P. gingivalis infection. Jixueteng showed a concentration-dependent reactive oxygen species (ROS) scavenging activity. Alveolar bone loss in mice administered Jixueteng with P. gingivalis was significantly lower than that in infection group. Administration of Jixueteng improved gingival microcirculation. These result suggest that Jixueteng may be useful as a therapeutic and preventive agent for bone diseases such as periodontitis.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Protective effects of (6R)-5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva2016
Author(s)
Tanaka Y, Toyama T, Wada-Takahashi S, Sasaki H, Miyamoto C, Maehata Y, Yoshino F, Yoshida A, Takahashi S-S, Watanabe K, Lee M-C, Todoki K, Hamada N
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 58
Issue: 1
Pages: 69-75
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Porphyromonas gingivalis infection modifies oral microcirculation and aortic vascular function in the stroke-prone spontaneously hypertensive rat (SHRSP).2016
Author(s)
Funaki S, Tokutomi F, Wada-Takahashi S, Yoshino F, Yoshida A, Maehata Y, Miyamoto C, Toyama T, Sato T, Hamada N, Lee M-C, Takahashi S-S
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Journal Title
Microbial Pathogenesis
Volume: 92
Pages: 36-42
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss2015
Author(s)
Bhawal UK, Lee HJ, Arikawa K, Shimosaka M, Suzuki M, Toyama T, Sato T, Kawamata R, Taguchi C, Hamada N, Nasu I, Arakawa H, Shibutani K
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Journal Title
International Journal of Oral Science
Volume: 7(4)
Issue: 4
Pages: 242-249
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Antibacterial activity of infrared free-electron laser on cariogenic bacteria.2017
Author(s)
Toyama T, Fujioka J, Koyata Y, Sakuma T, Watanabe K, Sasaki H, Yoshino F, Yoshida A, Imai Y, Ono Y, Tsukiyama K, Hamada N
Organizer
The International Association for Dental Research 95th General Session & Exhibition of the IADR
Related Report
Int'l Joint Research
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