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Roles of Jixueteng in therapeutic agents for periodontitis

Research Project

Project/Area Number 15K11434
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

Toshizo Toyama  神奈川歯科大学, 歯学部, 特任講師 (60638906)

Co-Investigator(Kenkyū-buntansha) 浜田 信城  神奈川歯科大学, 大学院歯学研究科, 教授 (20247315)
吉野 文彦  神奈川歯科大学, 大学院歯学研究科, 准教授 (20308307)
高橋 俊介  神奈川歯科大学, 大学院歯学研究科, 教授 (60206810)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords鶏血藤 / 歯周炎 / 殺菌作用 / 抗酸化作用 / 歯槽骨吸収抑制 / 細菌 / 歯周病 / 活性酸素 / 歯肉微小循環 / 生薬
Outline of Final Research Achievements

We investigated the preventive effects of Jixueteng, Chinese herbal medicine, on periodontitis using mouse experimental periodontitis model induced by P. gingivalis infection. Jixueteng possessed bactericidal effect against P. gingivalis in a dose-dependent manner. In P. gingivalis-infected mice, significant alveolar bone resorption and remarkable reduction in gingival vascular function via oxidative stress were observed. Morphological degeneration of vessels was also observed in the number of vascular networks abnormality of the vascular lumen was caused by P. gingivalis infection. Jixueteng showed a concentration-dependent reactive oxygen species (ROS) scavenging activity. Alveolar bone loss in mice administered Jixueteng with P. gingivalis was significantly lower than that in infection group. Administration of Jixueteng improved gingival microcirculation. These result suggest that Jixueteng may be useful as a therapeutic and preventive agent for bone diseases such as periodontitis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (26 results)

All 2017 2016 2015 Other

All Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (19 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Journal Article] Antimicrobial effect of blue light using Porphyromonas gingivalis pigment2017

    • Author(s)
      Yoshida Ayaka、Sasaki Haruka、Toyama Toshizo、Araki Mitsunori、Fujioka Jun、Tsukiyama Koichi、Hamada Nobushiro、Yoshino Fumihiko
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 5225-5225

    • DOI

      10.1038/s41598-017-05706-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] α-glucosyl hesperidin suppressed the exacerbation of 5-fluorouracil-induced oral mucositis in the hamster cheek pouch.2016

    • Author(s)
      Yoshino F, Yoshida A, Toyama T, Wada-Takahashi S, Takahashi S-S
    • Journal Title

      Journal of Functional Foods

      Volume: 21 Pages: 223-231

    • DOI

      10.1016/j.jff.2015.12.008

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Protective effects of (6R)-5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva2016

    • Author(s)
      Tanaka Y, Toyama T, Wada-Takahashi S, Sasaki H, Miyamoto C, Maehata Y, Yoshino F, Yoshida A, Takahashi S-S, Watanabe K, Lee M-C, Todoki K, Hamada N
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 1 Pages: 69-75

    • DOI

      10.3164/jcbn.15-69

    • NAID

      130005116629

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Porphyromonas gingivalis infection modifies oral microcirculation and aortic vascular function in the stroke-prone spontaneously hypertensive rat (SHRSP).2016

    • Author(s)
      Funaki S, Tokutomi F, Wada-Takahashi S, Yoshino F, Yoshida A, Maehata Y, Miyamoto C, Toyama T, Sato T, Hamada N, Lee M-C, Takahashi S-S
    • Journal Title

      Microbial Pathogenesis

      Volume: 92 Pages: 36-42

    • DOI

      10.1016/j.micpath.2015.12.009

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Porphyromonas gingivalis-induced alveolar bone loss is accelerated in the stroke-prone spontaneously hypertensive rat.2015

    • Author(s)
      Tokutomi F, Wada-Takahashi S, Sugiyama S, Toyama T, Sato T, Hamada N, Tsukinoki K, Takahashi SS, Lee MC
    • Journal Title

      Arch Oral Biol

      Volume: 60 Issue: 6 Pages: 911-918

    • DOI

      10.1016/j.archoralbio.2015.02.012

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss2015

    • Author(s)
      Bhawal UK, Lee HJ, Arikawa K, Shimosaka M, Suzuki M, Toyama T, Sato T, Kawamata R, Taguchi C, Hamada N, Nasu I, Arakawa H, Shibutani K
    • Journal Title

      International Journal of Oral Science

      Volume: 7(4) Issue: 4 Pages: 242-249

    • DOI

      10.1038/ijos.2015.28

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] The Effect of α-glucosyl Hesperidin on Oral Mucositis Induced by Treatment of 5-fluorouracil with Acetic Acid2017

    • Author(s)
      Yoshino F, Yoshida A, Toyama T
    • Organizer
      CED-IADR/NOF Oral Health Research Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス実験的歯周炎モデルにおける生薬「鶏血藤」の循環改善効果2017

    • Author(s)
      遠山歳三,塗々木和男,高橋俊介,吉野文彦,吉田彩佳,松尾雅斗,高橋聡子,佐々木悠,稲葉啓太郎,渡辺清子,浜田信城
    • Organizer
      日本歯周病学会60周年記念京都大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フランス海岸松樹皮抽出物による口腔バイオフィルム形成抑制効果の検討2017

    • Author(s)
      渡辺清子,平嶺浩子,遠山歳三,佐々木悠,稲葉啓太郎,浜田信城
    • Organizer
      日本歯周病学会60周年記念京都大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Antibacterial activity of infrared free-electron laser on cariogenic bacteria.2017

    • Author(s)
      Toyama T, Fujioka J, Koyata Y, Sakuma T, Watanabe K, Sasaki H, Yoshino F, Yoshida A, Imai Y, Ono Y, Tsukiyama K, Hamada N
    • Organizer
      The International Association for Dental Research 95th General Session & Exhibition of the IADR
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フランス海岸松樹皮抽出物の歯垢形成抑制効果2016

    • Author(s)
      渡辺清子, 平嶺浩子, 遠山歳三, 佐々木悠, 浜田信城
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Aggressive Periodontitis Associated with Palmoplantar Pustulos.2016

    • Author(s)
      Takaaki Sakuma, Toshizo Toyama Keiso Takahashi
    • Organizer
      102nd American Academy of Periodontology 2016 Annual Meeting.
    • Place of Presentation
      San Diego
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of omega-3 acids on alveolar bone loss and osteoclasts differentiaon.2016

    • Author(s)
      Y. Ozaki, K. Watanabe, T. Toyama, A. Miyamoto, T. Sato, H. Sasaki C. Kudo, N.Hamada, M. Minabe
    • Organizer
      102nd American Academy of Periodontology 2016 Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] オメガ 3 脂肪酸の歯周炎および破骨細胞分化誘導に対する抑制効果の検討2016

    • Author(s)
      30.尾崎 悠, 渡辺清子, 遠山歳三, 宮本阿礼, 佐藤武則, 東 雅啓,佐々木 悠, 工藤値英子,浜田信城, 槻木恵一, 三辺正人
    • Organizer
      日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
  • [Presentation] オメガ 3 脂肪酸の歯周炎および破骨細胞分化誘導抑制効果に関する研究2016

    • Author(s)
      尾崎 悠, 渡辺清子, 遠山歳三, 宮本阿礼, 佐藤武則, 東 雅啓, 佐々木 悠,工藤値英子, 浜田信城, 槻木恵一, 三辺正人
    • Organizer
      神奈川歯科大学学会第150回例会
    • Place of Presentation
      横須賀
    • Related Report
      2016 Research-status Report
  • [Presentation] オメガ 3 脂肪酸の歯槽骨吸収および破骨細胞分化誘導抑制効果に関する研究2016

    • Author(s)
      尾崎 悠, 渡辺清子, 遠山歳三, 宮本阿礼, 佐藤武則, 東 雅啓,佐々木 悠, 工藤値英子,浜田信城, 槻木恵一, 三辺正人
    • Organizer
      第51回神奈川歯科大学学会総会
    • Place of Presentation
      横須賀
    • Related Report
      2016 Research-status Report
  • [Presentation] フランス海岸松抽出物の歯垢形成抑制効果の検討2016

    • Author(s)
      渡辺清子, 平嶺浩子, 遠山歳三, 佐々木 悠, 浜田信城
    • Organizer
      第51回神奈川歯科大学学会総会
    • Place of Presentation
      横須賀
    • Related Report
      2016 Research-status Report
  • [Presentation] 青色発光ダイオード照射はラット口蓋歯肉の酸化ストレスを亢進する2016

    • Author(s)
      36.吉田彩佳, 小椋有香子,高橋聡子, 高橋俊介, 遠山歳三, 吉野文彦
    • Organizer
      第51回神奈川歯科大学学会総会
    • Place of Presentation
      横須賀
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット歯肉における局所虚血/再灌流誘発反応性充血の抑制に対する(6R)-5,6,7.8-tetrahydro-L-biopterinの保護効果2015

    • Author(s)
      田中優作,遠山歳三,高橋聡子,佐々木悠,宮本千央,前畑洋次郎,吉野文彦,吉田彩佳,高橋俊介,渡辺清子,李昌一,塗々木和男,浜田信城
    • Organizer
      神奈川歯科大学学会第50回総会
    • Place of Presentation
      横須賀
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Alteration of oral vascular function in Porphyromonas gingivalis infection and/or stroke model.2015

    • Author(s)
      舩木誠子,徳富文彬,高橋聡子,吉野文彦,吉田彩佳,前畑洋次郎,宮本千央,遠山歳三,佐藤武則,浜田信城,李 昌一,高橋俊介
    • Organizer
      神奈川歯科大学学会第50回総会
    • Place of Presentation
      横須賀
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Protective effects of (6R)-5,6,7.8-tetrahydro-L-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva.2015

    • Author(s)
      田中優作,遠山歳三,高橋聡子,佐々木悠,宮本千央,前畑洋次郎,吉野文彦,吉田彩佳,高橋俊介,渡辺清子,李昌一,塗々木和男,浜田信城
    • Organizer
      神奈川歯科大学学会第148回例会
    • Place of Presentation
      横須賀
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 実験的歯周炎モデルにおける反応性充血を用いた血管内皮機能評価と生薬「鶏血藤の」内皮機能改善効果の検討2015

    • Author(s)
      遠山歳三,塗々木和男,高橋俊介,吉野文彦,吉田彩佳,高橋聡子,渡辺清子,浜田信城
    • Organizer
      第8回日本口腔検査学会総会・学術大会
    • Place of Presentation
      横須賀
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] FMD (Flow Mediated Dilation) による血管内皮機能検査の意義と口腔内への応用の可能性について2015

    • Author(s)
      高橋俊介,杉山秀太,高橋聡子,吉野文彦,吉田彩佳,前畑洋次郎,宮本千央,松尾雅斗,李昌一,遠山歳三,佐藤武則,渡辺清子,浜田信城,児玉利朗
    • Organizer
      第8回日本口腔検査学会総会・学術大会
    • Place of Presentation
      横須賀
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 2型糖尿病による歯肉循環調節機能(血管弾性)の変化 -FMDによる血管内皮機能検査の口腔内への応用-2015

    • Author(s)
      杉山秀太,高橋俊介,高橋聡子,吉野文彦,吉田彩佳,前畑洋次郎,宮本千央,松尾雅斗,李昌一,遠山歳三,佐藤武則,渡辺清子,浜田信城,児玉利朗
    • Organizer
      第8回日本口腔検査学会総会・学術大会
    • Place of Presentation
      横須賀
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] ラット歯肉局所循環調節機構に対する抗酸化生体因子(BH4)の役割2015

    • Author(s)
      遠山歳三,塗々木和男,高橋俊介,高橋聡子,吉野文彦,吉田彩佳,渡辺清子,浜田 信城
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Remarks] 神奈川歯科大学大学院口腔科学講座光歯科医学

    • URL

      http://www.labs.kdu.ac.jp/pmd/

    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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