Study on sleep disorder of patients with Cancer-treatment-Related Lymphedema

• Project/Area Number: 15K11468
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Fundamental nursing
• Research Institution: Nagoya University
• Principal Investigator: Oshima Chika 名古屋大学, 医学系研究科(保健), 准教授 (30405063)
• Co-Investigator(Kenkyū-buntansha): 藤本 悦子 関西医科大学, 看護学部, 教授 (00107947) ; 間脇 彩奈 名古屋大学, 医学系研究科(保健), 助教 (10533341) ; 竹野 ゆかり 名古屋大学, 医学系研究科(保健), 助教 (20509088)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: リンパ浮腫 / 多層包帯法 / 睡眠 / 乳がん

Outline of Final Research Achievements

Multi-layer bandaging (MLB) are very effective in the management oflymphedema. However, MLB is considered to add stress to patients such as pressure and　restricted movement on extremity, hence, MLB during night may disrupt their sleep.This study examined whether MLB disrupt the sleep.This study recruited 14 healthy female volunteers and six female patients with stage II lymphedema as a result of breast cancer surgery. Both of the healthy volunteer group and the patient group were required to wear a wrist actigraph for 2 weeks. In the healthy volunteer group, MLB increased only WASO on the first day but WASO recovered on the seventh day. In the patient group, MLB shorten SLAT on the seventh day, meaning to fall asleep easily.
These results suggest that wearing MLB may not reduce the quality of sleep during the night in patients with breast cancer-related lymphedema.

Academic Significance and Societal Importance of the Research Achievements

がん患者は、不眠症や睡眠覚醒周期に障害をきたすリスクがきわめて高く、中でもリンパ浮腫を合併した患者では、がん治療終了後も睡眠障害が持続することが報告されている。2008年には、日本における乳がんの発生率と睡眠時間に関する研究報告が発表され、乳がんの発症予防・再発予防には適切な睡眠の確保が必要ということが、広く認知されるようになった。再発の不安を常に抱えるリンパ浮腫患者にとって、夜間帯の多層包帯法導入は、大きな不安を伴うものであったが、本研究により睡眠障害への懸念が払拭された。これまで多層包帯法の導入に踏み切れなかったリンパ浮腫患者も、今後は、安心してその恩恵にあずかることができるようになる。

Research Products

• [Presentation] Skin Viscoelasticity in Patients with Lymphedema. (2018)
  • Author(s): Ayana Mawaki, Chika Oshima, Keisuke Nakanishi et al.
  • Organizer: 8th International Lymphoedema Framework. 2018 Jun 6-9. Rotterdam, Netherlands.
  • Int'l Joint Research
• [Presentation] リンパ浮腫の皮下組織における水分分布と厚さの比較-MR画像および超音波画像を用いた検討-， (2018)
  • Author(s): 丹羽史織, 間脇彩奈 他：
  • Organizer: コ・メディカル形態機能学会第17回学術集会，佐賀市（2018年9月）
• [Presentation] Temporal changes in interface pressure of multilayer bandages on the upper extremity (2017)
  • Author(s): Ayana Mawaki, Yukiko Kunieda, Kana Omura, Chika Oshima, Yukari Takeno, Keisuke Nakanishi, Etsuko Fujimoto
  • Organizer: 7th International Lymphoedema Framework Conference (Siracusa, Italy)
  • Int'l Joint Research
• [Presentation] The influence of multi-layer bandaging on the overnight sleep quality (2017)
  • Author(s): Chika Oshima, Ayana Mawaki, Keisuke Nakanishi, Fumiya Kurono, Yukari Takeno, Etsuko Fujimoto
  • Organizer: 25th World Congress of Lymphology (Barcelona, Spain)
  • Int'l Joint Research
• [Presentation] Nighttime bandaging may not affect household and locomotive activities of patients with breast cancer-related lymphedema (2017)
  • Author(s): Keisuke Nakanishi, Ayana Mawaki, Chika Oshima, Yukari Takeno, Fumiya Kurono, Shiori Niwa, Aya Ando, Sayami Matsubara and Etsuko Fujimoto
  • Organizer: TNMC & WANS International Nursing Research Conference (Bangkok, Thailand)
  • Int'l Joint Research
• [Presentation] 多層包帯下における温湿度と角質水分量の変化 (2016)
  • Author(s): 平手志歩、大島千佳、間脇彩奈、中西啓介、黒野史椰、竹野ゆかり、藤本悦子
  • Organizer: 日本看護技術学会第15 回学術集会
  • Place of Presentation: 群馬
  • Year and Date: 2016-09-24
• [Presentation] The influence of multi-layer bandaging on the overnight sleep of patients with breast cancer-related lymphedema (2016)
  • Author(s): Chika Oshima, Ayana Mawaki, Keisuke Nakanishi, Fumiya Kurono, Yukari Takeno, Etsuko Fujimoto
  • Organizer: The 2016 NLN Conference
  • Place of Presentation: アメリカ合衆国
  • Year and Date: 2016-08-31
• [Presentation] NIGHT-TIME MULTILAYERED BANDAGING: IS IT BENEFICIAL FOR THE REDUCTION OF SWELLING DUE TO LYMPHEDEMA? (2016)
  • Author(s): Keisuke Nakanishi, Ayana Mawaki, Chika Ohsima, Yukari Takeno, Humiya Kurono, Aya Ando, Sayami Matsubara, Etsuko Fujimoto
  • Organizer: The 2016 NLN Conference
  • Place of Presentation: アメリカ合衆国
  • Year and Date: 2016-08-31
• [Presentation] 上肢への多層包帯法がリンパ浮腫患者の睡眠に与える影響 (2016)
  • Author(s): 大島千佳,間脇彩奈,中西啓介,黒野史椰,竹野ゆかり,藤本悦子
  • Organizer: コメディカル・形態機能学会第15回学術集会
  • Place of Presentation: 京都
• [Presentation] セルフバンデージ技術の指導回数と習得プロセス (2016)
  • Author(s): 間脇彩奈、中西啓介、黒野史椰、大島千佳、竹野ゆかり、藤本悦子
  • Organizer: 国際リンパ浮腫フレームワーク・ジャパン研究協議会第6回学術集会
  • Place of Presentation: 大阪
• [Presentation] リンパ浮腫ケアの新たなステージー確かな実践に向けてー (2015)
  • Author(s): 藤本悦子,大島千佳、竹野ゆかり,間脇彩奈,谷保由依子,中西啓介,黒野史椰，永谷幸子
  • Organizer: 日本看護技術学会第14回学術集会
  • Place of Presentation: 愛媛県ひめぎんホール
  • Year and Date: 2015-10-17
• [Presentation] 多層包帯法が睡眠に与える影響 (2015)
  • Author(s): 児玉侑紀,高羽杏奈,大島千佳,間脇彩奈,竹野ゆかり,藤本悦子
  • Organizer: コ・メディカル形態機能学会第14回学術集会
  • Place of Presentation: 埼玉医科大学
  • Year and Date: 2015-09-26